Title:
USE OF dsRNAs IN STRATEGIC THERAPEUTIC INTERVENTION OF HIGHLY ACTIVE ANTIRETROVIRAL THERAPY
Document Type and Number:
WIPO Patent Application WO2003051301
Kind Code:
A3
Abstract:
In the treatment of HIV administration of dsRNA at an appropriate stage in highly active antiretroviral (HAART) therapy of HIV allows for the discontinuation of HAART by increasing the time to HIV rebound after stopping HAART.
Inventors:
CARTER WILLIAM A (US)
STRAYER DAVID R (US)
STRAYER DAVID R (US)
Application Number:
PCT/US2002/039890
Publication Date:
December 18, 2003
Filing Date:
December 13, 2002
Export Citation:
Assignee:
HEMISPHERX BIOPHARMA (US)
CARTER WILLIAM A (US)
STRAYER DAVID R (US)
CARTER WILLIAM A (US)
STRAYER DAVID R (US)
International Classes:
A61K31/341; A61K31/52; A61K31/7072; A61K31/7088; A61K31/711; A61K45/06; (IPC1-7): A61K31/70
Foreign References:
| US4950652A | 1990-08-21 |
Other References:
RUIZ ET AL.: "HIV dynamics and T-cell immunity after three structured treatment interruptions in chronic HIV-1 infection", AIDS, vol. 15, no. 9, 13 March 2001 (2001-03-13), pages F19 - F27, XP002963903
BIRK ET AL.: "Kinetics of HIV-1 RNA and resistance-associated mutations after cessation of antiretroviral combination therapy", AIDS, vol. 15, no. 11, 6 April 2001 (2001-04-06), pages 1359 - 1368, XP002963904
BIRK ET AL.: "Kinetics of HIV-1 RNA and resistance-associated mutations after cessation of antiretroviral combination therapy", AIDS, vol. 15, no. 11, 6 April 2001 (2001-04-06), pages 1359 - 1368, XP002963904
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