Title:
USE OF ANTIBODY-DRUG CONJUGATES AND ANTIBODIES FOR DRUG DELIVERY
Document Type and Number:
WIPO Patent Application WO/2021/125263
Kind Code:
A1
Abstract:
An objective of the present invention is to provide a novel drug delivery means that targets neovascularization. An objective of the present invention is to provide a novel drug delivery means that targets induced vascular permeability. Another objective of the present invention is to provide a method and detection reagent for treating or diagnosing various types of diseases, such as malignancies. A conjugate of a drug and an anti-HMGB1 antibody or an antigen-binding fragment thereof is administered and taken up by vascular endothelial cells in neovascularized or permeability-induced blood vessels, thereby delivering the drug into the cells. Also provided are a method and detection reagent for treating or diagnosing various types of diseases, such as malignancies, by using the conjugate.
Inventors:
NISHIBORI MASAHIRO (JP)
MORI SHUJI (JP)
GAO SHANGZE (JP)
SAKAGUCHI MASAKIYO (JP)
TOMONO YASUKO (JP)
MORI SHUJI (JP)
GAO SHANGZE (JP)
SAKAGUCHI MASAKIYO (JP)
TOMONO YASUKO (JP)
Application Number:
PCT/JP2020/047157
Publication Date:
June 24, 2021
Filing Date:
December 17, 2020
Export Citation:
Assignee:
NAT UNIV CORPORATION OKAYAMA UNIV (JP)
SOWAKAI MEDICAL FOUND (JP)
SOWAKAI MEDICAL FOUND (JP)
International Classes:
A61K47/68; A61K39/395; A61P3/10; A61P9/00; A61P9/10; A61P17/02; A61P17/06; A61P25/00; A61P25/08; A61P27/02; A61P27/06; A61P29/00; A61P35/00; C07K16/18
Domestic Patent References:
| WO2014115430A1 | 2014-07-31 | |||
| WO2007049468A1 | 2007-05-03 |
Foreign References:
| US20140127134A1 | 2014-05-08 | |||
| JP2016518332A | 2016-06-23 | |||
| JP2006517537A | 2006-07-27 | |||
| US20090252739A1 | 2009-10-08 | |||
| US20090274713A1 | 2009-11-05 |
Other References:
ANNUAL REVIEW OF IMMUNOLOGY, vol. 29, 2011, pages 139 - 162
NIHON YAKURIGAKU ZASSHI, vol. 151, 2018, pages 4 - 8
JOURNAL OF PHARMACOLOGICAL SCIENCE, vol. 140, 2019, pages 94 - 101
KABAT, E.A. ET AL.: "Sequences of Proteins of Immunological Interest", 1991, PUBLIC HEALTH SERVICE, NATIONAL INSTITUTES OF HEALTH
HUDSON, PJ ET AL., NAT. MED., vol. 9, 2003, pages 129 - 134
PLUECKTHUN, A.: "The Pharmacology of Monoclonal Antibodies", vol. 113, 1994, SPRINGER-VERLAG, pages: 269 - 315
NATURE, vol. 341, 1989, pages 544 - 546
FASEB J., vol. 21, 2007, pages 3904 - 3916
NATURE MEDICINE, vol. 17, 2011, pages 1685 - 1691
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS
See also references of EP 3875118A4
NIHON YAKURIGAKU ZASSHI, vol. 151, 2018, pages 4 - 8
JOURNAL OF PHARMACOLOGICAL SCIENCE, vol. 140, 2019, pages 94 - 101
KABAT, E.A. ET AL.: "Sequences of Proteins of Immunological Interest", 1991, PUBLIC HEALTH SERVICE, NATIONAL INSTITUTES OF HEALTH
HUDSON, PJ ET AL., NAT. MED., vol. 9, 2003, pages 129 - 134
PLUECKTHUN, A.: "The Pharmacology of Monoclonal Antibodies", vol. 113, 1994, SPRINGER-VERLAG, pages: 269 - 315
NATURE, vol. 341, 1989, pages 544 - 546
FASEB J., vol. 21, 2007, pages 3904 - 3916
NATURE MEDICINE, vol. 17, 2011, pages 1685 - 1691
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS
See also references of EP 3875118A4
Attorney, Agent or Firm:
UNIUS PATENT ATTORNEYS OFFICE (JP)
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