Title:
USE OF CELL LINES TO PRODUCE ACTIVE THERAPEUTIC PROTEINS
Document Type and Number:
WIPO Patent Application WO2005034876
Kind Code:
A3
Abstract:
This invention relates to the production of proteins, including therapeutic plasma proteins, by virally-immortalized hepatocyte cell lines and by other eukaryotic cells, as well as to the use of such proteins for screening and therapy, as well as to nucleic acids, vectors, and transformed or transfected cells that carry the genetic information for proteins.
Inventors:
BUSH THOMAS S (US)
FARIS RONALD A (US)
LIU JIN (US)
FARIS RONALD A (US)
LIU JIN (US)
Application Number:
PCT/US2004/033260
Publication Date:
October 06, 2005
Filing Date:
October 07, 2004
Export Citation:
Assignee:
MULTICELL TECHNOLOGIES INC (US)
BUSH THOMAS S (US)
FARIS RONALD A (US)
LIU JIN (US)
BUSH THOMAS S (US)
FARIS RONALD A (US)
LIU JIN (US)
International Classes:
A61K38/19; C12N5/071; C12N15/00; C12N15/85; C12N15/86; C12P21/00; G01N33/50; A61K38/00; A61K; (IPC1-7): C12N15/85; C12N15/86; C12N15/00; C12P21/00; A61K38/19
Foreign References:
| US6517830B1 | 2003-02-11 | |||
| US6806351B2 | 2004-10-19 |
Other References:
KOBAYASHI ET AL: "Improvement in the differentiated phenotype of immortalized human hepatocytes mediated p21 gene transfer.", ASAIO J., vol. 48, no. 4, July 2002 (2002-07-01), pages 355 - 359, XP001199772
LUCAS B. ET AL: "High-level production of recombinant proteins in CHO cells using a dicistronic DHFR intron expression vector.", NUC.ACIDS RES., vol. 24, no. 9, October 1996 (1996-10-01), pages 1775 - 1778, XP002151702
MILLS J. ET AL: "Induction of drug metabolism enzymes and MDR1 using a noel human hepatocyte cell line.", EXP. LINE.J. PHARMAC., vol. 309, no. 1, 2004, pages 303 - 304, XP002989130
JANSSEN U. ET AL: "Expression of inter-alpha-trypsin inhibitor and tumor necrosis factostimulated gene 6 in renal proximal tubular epithelial cells.", KIDNEY INTERNATIONAL, vol. 60, no. 1, September 2001 (2001-09-01), pages 127 - 129, XP002983362
LUCAS B. ET AL: "High-level production of recombinant proteins in CHO cells using a dicistronic DHFR intron expression vector.", NUC.ACIDS RES., vol. 24, no. 9, October 1996 (1996-10-01), pages 1775 - 1778, XP002151702
MILLS J. ET AL: "Induction of drug metabolism enzymes and MDR1 using a noel human hepatocyte cell line.", EXP. LINE.J. PHARMAC., vol. 309, no. 1, 2004, pages 303 - 304, XP002989130
JANSSEN U. ET AL: "Expression of inter-alpha-trypsin inhibitor and tumor necrosis factostimulated gene 6 in renal proximal tubular epithelial cells.", KIDNEY INTERNATIONAL, vol. 60, no. 1, September 2001 (2001-09-01), pages 127 - 129, XP002983362
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