Title:
USE OF COMPOSITION FOR PLATELET DISAGGREGATION, DISAGGREGATION REAGENT, AND DISAGGREGATION METHOD
Document Type and Number:
WIPO Patent Application WO/2022/016343
Kind Code:
A1
Abstract:
A use of a composition for preventing and/or eliminating platelet aggregation in a blood sample in ex-vivo blood test. The composition comprises at least one ammonium ion-containing compound. A reagent comprising the compound and used for anti-platelet aggregation interference in ex-vivo blood test, and a method for preventing and/or eliminating platelet aggregation in a sample in ex-vivo blood test. The compound has a disaggregation effect on a plurality of platelet aggregation conditions, and can disaggregate platelets within a short period of time, without needing additional conditions such as water bath temperature control and prolonging a reaction time, and thus can conveniently eliminate platelet aggregation in the sample and obtain accurate measurement parameters of blood cells.
Inventors:
GAO FEI (CN)
ZHANG ZIQIAN (CN)
ZHANG ZIQIAN (CN)
Application Number:
PCT/CN2020/103133
Publication Date:
January 27, 2022
Filing Date:
July 20, 2020
Export Citation:
Assignee:
SHENZHEN MINDRAY BIOMEDICAL ELECTRONICS CO LTD (CN)
International Classes:
A61K31/13; A61K31/131; A61K31/135; A61K31/136; A61K31/14; A61K31/145; A61K33/02; A61K33/04; A61K33/10; A61K33/18; A61P7/02
Foreign References:
| US4382945A | 1983-05-10 | |||
| CN109251234A | 2019-01-22 | |||
| CN1128028A | 1996-07-31 | |||
| CN1136808A | 1996-11-27 | |||
| CN102320986A | 2012-01-18 |
Other References:
SHINYA HIROSHI, MATSUO NOBUAKI, TAKEYAMA NAOSHI, TANAKA TAKAYA: "Hyperammonemia inhibits platelet aggregation in rats", THROMBOSIS RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 81, no. 2, 15 January 1996 (1996-01-15), AMSTERDAM, NL , pages 195 - 201, XP055888137, ISSN: 0049-3848, DOI: 10.1016/0049-3848(95)00236-7
KITAGAWA, S. ; SEKI, H. ; KAMETANI, F.: "Effects of monovalent cations and anions on ADP-induced aggregation of bovine platelets, and mechanism thereof", BIOCHIMICA ET BIOPHYSICA ACTA, ELSEVIER, AMSTERDAM, NL, vol. 840, no. 3, 5 July 1985 (1985-07-05), AMSTERDAM, NL , pages 371 - 376, XP025788851, ISSN: 0304-4165, DOI: 10.1016/0304-4165(85)90217-X
KITAGAWA, S. ; ISHIDA, M. ; KOTANI, K. ; KAMETANI, F.: "Inhibitory effects of long-chain alkyltrimethylammonium ions on aggregation of bovine platelets and the relation of their effects to Ca^2^+ mobilization", BIOCHIMICA ET BIOPHYSICA ACTA, ELSEVIER, AMSTERDAM, NL, vol. 905, no. 1, 27 November 1987 (1987-11-27), AMSTERDAM, NL , pages 75 - 80, XP023504190, ISSN: 0005-2736, DOI: 10.1016/0005-2736(87)90010-1
REHSE KLAUS, KÄMPFE MICHAEL: "Antiaggregatorische und anticoagulante Eigenschaften von Oligoaminen, 10. Mitt: Oligotertiäre Amine und oligoquartäre Ammoniumsalze", ARCHIV DER PHARMAZIE, WILEY VERLAG, WEINHEIM, vol. 322, no. 11, 1 January 1989 (1989-01-01), Weinheim , pages 811 - 815, XP055888141, ISSN: 0365-6233, DOI: 10.1002/ardp.19893221107
KITAGAWA, S. ; AWAI, M. ; KAMETANI, F.: "Relationship of the effects of nigericin on the aggregation and cytoplasmic pH of bovine platelets in the presence of different cations", BIOCHIMICA ET BIOPHYSICA ACTA, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM., NL, vol. 930, no. 1, 19 August 1987 (1987-08-19), NL , pages 48 - 54, XP025210829, ISSN: 0167-4889, DOI: 10.1016/0167-4889(87)90154-6
KITAGAWA, S. ; SEKI, H. ; KAMETANI, F.: "Effects of monovalent cations and anions on ADP-induced aggregation of bovine platelets, and mechanism thereof", BIOCHIMICA ET BIOPHYSICA ACTA, ELSEVIER, AMSTERDAM, NL, vol. 840, no. 3, 5 July 1985 (1985-07-05), AMSTERDAM, NL , pages 371 - 376, XP025788851, ISSN: 0304-4165, DOI: 10.1016/0304-4165(85)90217-X
KITAGAWA, S. ; ISHIDA, M. ; KOTANI, K. ; KAMETANI, F.: "Inhibitory effects of long-chain alkyltrimethylammonium ions on aggregation of bovine platelets and the relation of their effects to Ca^2^+ mobilization", BIOCHIMICA ET BIOPHYSICA ACTA, ELSEVIER, AMSTERDAM, NL, vol. 905, no. 1, 27 November 1987 (1987-11-27), AMSTERDAM, NL , pages 75 - 80, XP023504190, ISSN: 0005-2736, DOI: 10.1016/0005-2736(87)90010-1
REHSE KLAUS, KÄMPFE MICHAEL: "Antiaggregatorische und anticoagulante Eigenschaften von Oligoaminen, 10. Mitt: Oligotertiäre Amine und oligoquartäre Ammoniumsalze", ARCHIV DER PHARMAZIE, WILEY VERLAG, WEINHEIM, vol. 322, no. 11, 1 January 1989 (1989-01-01), Weinheim , pages 811 - 815, XP055888141, ISSN: 0365-6233, DOI: 10.1002/ardp.19893221107
KITAGAWA, S. ; AWAI, M. ; KAMETANI, F.: "Relationship of the effects of nigericin on the aggregation and cytoplasmic pH of bovine platelets in the presence of different cations", BIOCHIMICA ET BIOPHYSICA ACTA, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM., NL, vol. 930, no. 1, 19 August 1987 (1987-08-19), NL , pages 48 - 54, XP025210829, ISSN: 0167-4889, DOI: 10.1016/0167-4889(87)90154-6
Attorney, Agent or Firm:
CHINA PAT INTELLECTUAL PROPERTY OFFICE (CN)
Download PDF:
Previous Patent: CHANNEL SCRAMBLING METHOD AND TERMINAL DEVICE
Next Patent: SYSTEM AND METHOD OF TEMPERATURE CONTROLLED FLASK
Next Patent: SYSTEM AND METHOD OF TEMPERATURE CONTROLLED FLASK