Title:
USE OF DERIVATIVES OF SPIRONOLACTONE LIKE CANRENONE AS ANTI-FIBROGEGIC DRUG
Document Type and Number:
WIPO Patent Application WO2002087591
Kind Code:
A3
Abstract:
The invention relates to the use of a spironolactone compound to produce a drug for inhibiting the pro-fibrogenic effect of hepatic stellate cells and vascular smooth muscle cells, particularly in relation to fibrogenesis induced by pro-fibrogenic cytokines. Canrenone, potassium canrenoate, spironolactone and eplerenone are particularly preferred compounds for use in the invention.
Inventors:
PINZANI MASSIMO (IT)
VANASIA MASSIMO (IT)
VANASIA MASSIMO (IT)
Application Number:
PCT/EP2002/004211
Publication Date:
January 09, 2003
Filing Date:
April 16, 2002
Export Citation:
Assignee:
GIENNE PHARMA S P A (IT)
PINZANI MASSIMO (IT)
VANASIA MASSIMO (IT)
PINZANI MASSIMO (IT)
VANASIA MASSIMO (IT)
International Classes:
A61K31/585; A61P43/00; (IPC1-7): A61K31/585; A61P43/00
Domestic Patent References:
| WO2001041535A2 | 2001-06-14 | |||
| WO1995015166A1 | 1995-06-08 |
Foreign References:
| US5668124A | 1997-09-16 | |||
| US6150347A | 2000-11-21 | |||
| US4542024A | 1985-09-17 |
Other References:
YANG X ET AL: "CYP11B2 expression in rat liver and the effect of spironolactone on hepatic fibrogenesis.", HORMONE RESEARCH. SWITZERLAND 2000, vol. 53, no. 6, 2000, pages 288 - 293, XP001117827, ISSN: 0301-0163
LACOLLEY P ET AL: "Prevention of aortic and cardiac fibrosis by spironolactone in old normotensive rats.", JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. UNITED STATES FEB 2001, vol. 37, no. 2, February 2001 (2001-02-01), pages 662 - 667, XP001119401, ISSN: 0735-1097
CALIGIURI ALESSANDRA ET AL: "Inhibition of the sodium/hydrogen exchanger mediates the antifibrogenic effects of canrenone (CR) in human hepatic stellate cells (HSC).", HEPATOLOGY, vol. 30, no. 4 PART 2, October 1999 (1999-10-01), 50th Annual Meeting and Postgraduate Courses of the American Association for the Study of Liver Diseases;Dallas, Texas, USA; November 5-9, 1999, pages 485A, XP001119411, ISSN: 0270-9139
LACOLLEY P ET AL: "Prevention of aortic and cardiac fibrosis by spironolactone in old normotensive rats.", JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. UNITED STATES FEB 2001, vol. 37, no. 2, February 2001 (2001-02-01), pages 662 - 667, XP001119401, ISSN: 0735-1097
CALIGIURI ALESSANDRA ET AL: "Inhibition of the sodium/hydrogen exchanger mediates the antifibrogenic effects of canrenone (CR) in human hepatic stellate cells (HSC).", HEPATOLOGY, vol. 30, no. 4 PART 2, October 1999 (1999-10-01), 50th Annual Meeting and Postgraduate Courses of the American Association for the Study of Liver Diseases;Dallas, Texas, USA; November 5-9, 1999, pages 485A, XP001119411, ISSN: 0270-9139
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