Title:
USE OF IMMUNOGENIC T CELL EPITOPES FOR LYME DISEASE VACCINATION AND DIAGNOSIS
Document Type and Number:
WIPO Patent Application WO/2024/050512
Kind Code:
A3
Abstract:
Disclosed herein are compositions and methods for treating, and for the preventative treatment of Lyme disease. Also disclosed herein are compositions and methods for detecting and diagnosing infection by a Borrelia sp.
Inventors:
LOCHHEAD ROBERT B (US)
DANNER REBECCA L (US)
ROUSE JOSEPH R (US)
PROCHNIAK LAUREN (US)
DANNER REBECCA L (US)
ROUSE JOSEPH R (US)
PROCHNIAK LAUREN (US)
Application Number:
PCT/US2023/073311
Publication Date:
May 16, 2024
Filing Date:
September 01, 2023
Export Citation:
Assignee:
MEDICAL COLLEGE WISCONSIN INC (US)
International Classes:
A61K39/02; A61P31/04; C07K14/20; C07K16/12
Domestic Patent References:
| WO1998059071A1 | 1998-12-30 | |||
| WO2008031133A2 | 2008-03-20 |
Foreign References:
| US20160333056A1 | 2016-11-17 |
Other References:
ZÜCKERT WOLFRAM R, SANDKVIST MARIA; CHRISTIE PETER J: "Protein Secretion in Spirochetes", MICROBIOLSPECTRUM, 14 June 2019 (2019-06-14), XP093172933, Retrieved from the Internet DOI: 10.1128/microbiolspec.PSIB-0026-2019.
HATCHETTE TF, DAVIS I; JOHNSTON BL: "Lyme disease: clinical diagnosis and treatment", CANADA COMMUNICABLE DISEASE REPORT, vol. 40, no. 11, pages 194 - 208, XP093172935, DOI: 10.14745/ccdr.v40i11a01
HATCHETTE TF, DAVIS I; JOHNSTON BL: "Lyme disease: clinical diagnosis and treatment", CANADA COMMUNICABLE DISEASE REPORT, vol. 40, no. 11, pages 194 - 208, XP093172935, DOI: 10.14745/ccdr.v40i11a01
DATABASE Protein 14 April 2021 (2021-04-14), ANONYMOUS: "LPS-assembly protein LptD [Borreliella garinii]", XP093172939, Database accession no. WP_210359817.1
DATABASE Protein 17 August 2020 (2020-08-17), ANONYMOUS: "LPS-assembly protein LptD [Borreliella spielmanii]", XP093172940, Database accession no. WP_183223117.1
DATABASE Protein 30 January 2014 (2014-01-30), ANONYMOUS: "methyl-accepting chemotaxis protein [Borreliella afzelii HLJ01] ", XP093172941, Database accession no. AFU74984.1
DATABASE Protein 28 February 2022 (2022-02-28), ANONYMOUS: "PTS glucose transporter subunit IIA [Borreliella burgdorferi] ", XP093172942, Database accession no. WP-002662636.1
DATABASE Protein 28 February 2022 (2022-02-28), ANONYMOUS: "PTS glucose transporter subunit IIA [Borreliella bissettiae] ", XP093172943, Database accession no. WP-014023775.1
HATCHETTE TF, DAVIS I; JOHNSTON BL: "Lyme disease: clinical diagnosis and treatment", CANADA COMMUNICABLE DISEASE REPORT, vol. 40, no. 11, pages 194 - 208, XP093172935, DOI: 10.14745/ccdr.v40i11a01
HATCHETTE TF, DAVIS I; JOHNSTON BL: "Lyme disease: clinical diagnosis and treatment", CANADA COMMUNICABLE DISEASE REPORT, vol. 40, no. 11, pages 194 - 208, XP093172935, DOI: 10.14745/ccdr.v40i11a01
DATABASE Protein 14 April 2021 (2021-04-14), ANONYMOUS: "LPS-assembly protein LptD [Borreliella garinii]", XP093172939, Database accession no. WP_210359817.1
DATABASE Protein 17 August 2020 (2020-08-17), ANONYMOUS: "LPS-assembly protein LptD [Borreliella spielmanii]", XP093172940, Database accession no. WP_183223117.1
DATABASE Protein 30 January 2014 (2014-01-30), ANONYMOUS: "methyl-accepting chemotaxis protein [Borreliella afzelii HLJ01] ", XP093172941, Database accession no. AFU74984.1
DATABASE Protein 28 February 2022 (2022-02-28), ANONYMOUS: "PTS glucose transporter subunit IIA [Borreliella burgdorferi] ", XP093172942, Database accession no. WP-002662636.1
DATABASE Protein 28 February 2022 (2022-02-28), ANONYMOUS: "PTS glucose transporter subunit IIA [Borreliella bissettiae] ", XP093172943, Database accession no. WP-014023775.1
Attorney, Agent or Firm:
CHISHOLM, Robert D. (US)
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