Title:
USE OF MYCOBACTERIUM W FOR THE TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) DISEASE INFECTION
Document Type and Number:
WIPO Patent Application WO2002056906
Kind Code:
A3
Abstract:
Human Immunodeficiency virus causes depletion of CD4 cells. The depletion of CD4 cells results in decrease in immunity of an infected individual. Due to decrease immunity various opportunistic infections occur. These infections are cause for morbidity and mortality in HIV infected individuals. The treatment of HIV these includes antiretroviral drugs. These drugs have their own side effects and immune reconstitution achieved is delayed and slow. Various attempts have been made to improve CD4 count, use of IL-2 is one of them. It is associated with systemic side effects during the period of its administration. The present invention provides method of using mycobacterium w for the management of HIV. According to present invention mycobacterium w when given intradermally is effective in prophylaxis and treatment of AIDS or AIDS related complex (ARC). It is found to improve immunity as well as CD4 count. It is found to eliminate symptoms like fever, diarrhea. The effect is seen even when no antiretrovirals are used.
Inventors:
KHAMAR BAKULESH MAFATLAL (IN)
MODI INDRAVADAN AMBALAL (IN)
MODI INDRAVADAN AMBALAL (IN)
Application Number:
PCT/IB2002/000097
Publication Date:
February 20, 2003
Filing Date:
January 17, 2002
Export Citation:
Assignee:
KHAMAR BAKULESH MAFATLAL (IN)
MODI INDRAVADAN AMBALAL (IN)
MODI INDRAVADAN AMBALAL (IN)
International Classes:
A61K39/04; A61P31/18; A61K39/00; (IPC1-7): A61K39/04; A61K39/39; A61P31/18
Domestic Patent References:
| WO1991001751A1 | 1991-02-21 | |||
| WO1994006466A1 | 1994-03-31 |
Foreign References:
| GB2236480A | 1991-04-10 |
Other References:
GULERIA INDIRA ET AL: "In vivo depletion of CD4 and CD8 T lymphocytes impairs Mycobacterium w vaccine-induced protection against Mycobacterium tuberculosis in mice.", MEDICAL MICROBIOLOGY AND IMMUNOLOGY, vol. 182, no. 3, 1993, pages 129 - 135, XP001087510, ISSN: 0300-8584
BIFANI P J ET AL: "Identification of a W variant outbreak of Mycobacterium tuberculosis via population-based molecular epidemiology.", JAMA: THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. UNITED STATES 1999 DEC 22-29, vol. 282, no. 24, 22 December 1999 (1999-12-22), pages 2321 - 2327, XP001087514, ISSN: 0098-7484
BIFANI P J ET AL: "Identification of a W variant outbreak of Mycobacterium tuberculosis via population-based molecular epidemiology.", JAMA: THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. UNITED STATES 1999 DEC 22-29, vol. 282, no. 24, 22 December 1999 (1999-12-22), pages 2321 - 2327, XP001087514, ISSN: 0098-7484
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