Title:
USE OF TYROSINE KINASE INHIBITORS FOR TREATING INFLAMMATORY BOWEL DISEASES (IBD)
Document Type and Number:
WIPO Patent Application WO2003004007
Kind Code:
A3
Abstract:
The present invention relates to a method for treating inflammatory bowel diseases (IBD), such as crohn's disease, comprising administering a tyrosine kinase inhibitor to a human in need of such treatment, more particularly a non-toxic, selective and potent c-kit inhibitor. Preferably, said inhibitor is unable to promote death of IL-3 dependent cells cultured in presence of IL-3.
Inventors:
MOUSSY ALAIN (FR)
KINET JEAN-PIERRE (US)
KINET JEAN-PIERRE (US)
Application Number:
PCT/IB2002/003317
Publication Date:
August 28, 2003
Filing Date:
June 28, 2002
Export Citation:
Assignee:
AB SCIENCE (FR)
MOUSSY ALAIN (FR)
KINET JEAN-PIERRE (US)
MOUSSY ALAIN (FR)
KINET JEAN-PIERRE (US)
International Classes:
C07D401/04; A61K31/00; A61K31/015; A61K31/095; A61K31/40; A61K31/403; A61K31/404; A61K31/415; A61K31/4709; A61K31/495; A61K31/498; A61K31/50; A61K31/505; A61K31/506; A61K31/517; A61K31/519; A61K31/66; A61K45/00; A61K45/06; A61P1/00; A61P1/04; A61P43/00; G01N33/564; (IPC1-7): A61K31/00; A61K31/404; A61K31/505; A61K31/506; A61K31/519; A61K31/517; A61K31/498; A61K31/415; A61K31/4709; A61K31/015; A61K31/095; A61K31/66; A61P1/00
Domestic Patent References:
| WO1999065908A1 | 1999-12-23 | |||
| WO1998041525A1 | 1998-09-24 |
Foreign References:
| DE19824922A1 | 1999-12-09 | |||
| DE19844003A1 | 2000-03-30 |
Other References:
MOHAMMADI MOOSA ET AL: "Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.", SCIENCE (WASHINGTON D C), vol. 276, no. 5314, 1997, pages 955 - 960, XP002065235, ISSN: 0036-8075
KRYSTAL G W ET AL: "Indolinone tyrosine kinase inhibitors block Kit activation and growth of small cell lung cancer cells.", CANCER RESEARCH. UNITED STATES 1 MAY 2001, vol. 61, no. 9, 1 May 2001 (2001-05-01), pages 3660 - 3668, XP001080106, ISSN: 0008-5472
YAMATAKA A ET AL: "Localization of intestinal pacemaker cells and synapses in the muscle layers of a patient with colonic hypoganglionosis.", JOURNAL OF PEDIATRIC SURGERY. UNITED STATES APR 1996, vol. 31, no. 4, April 1996 (1996-04-01), pages 584 - 587, XP008010933, ISSN: 0022-3468
YAMATAKA A ET AL: "A lack of intestinal pacemaker (c-kit) in aganglionic bowel of patients with Hirschsprung's disease.", JOURNAL OF PEDIATRIC SURGERY. UNITED STATES MAR 1995, vol. 30, no. 3, March 1995 (1995-03-01), pages 441 - 444, XP008010934, ISSN: 0022-3468
KRYSTAL G W ET AL: "Indolinone tyrosine kinase inhibitors block Kit activation and growth of small cell lung cancer cells.", CANCER RESEARCH. UNITED STATES 1 MAY 2001, vol. 61, no. 9, 1 May 2001 (2001-05-01), pages 3660 - 3668, XP001080106, ISSN: 0008-5472
YAMATAKA A ET AL: "Localization of intestinal pacemaker cells and synapses in the muscle layers of a patient with colonic hypoganglionosis.", JOURNAL OF PEDIATRIC SURGERY. UNITED STATES APR 1996, vol. 31, no. 4, April 1996 (1996-04-01), pages 584 - 587, XP008010933, ISSN: 0022-3468
YAMATAKA A ET AL: "A lack of intestinal pacemaker (c-kit) in aganglionic bowel of patients with Hirschsprung's disease.", JOURNAL OF PEDIATRIC SURGERY. UNITED STATES MAR 1995, vol. 30, no. 3, March 1995 (1995-03-01), pages 441 - 444, XP008010934, ISSN: 0022-3468
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