Title:
USES OF IL-23 RELATED REAGENTS
Document Type and Number:
WIPO Patent Application WO2004071517
Kind Code:
A3
Abstract:
Provided are methods of treatment for inflammatory and autoimmune disorders of the central nervous system and gastrointestinal tract. Also provided are methods of diagnosis.
Inventors:
CUA DANIEL J (US)
CHEN YI (US)
KASTELEIN ROBERT A (US)
LANGRISH CLAIRE L (US)
RENNICK DONNA M (US)
SEDGWICK JONATHON (US)
CHEN YI (US)
KASTELEIN ROBERT A (US)
LANGRISH CLAIRE L (US)
RENNICK DONNA M (US)
SEDGWICK JONATHON (US)
Application Number:
PCT/US2004/003126
Publication Date:
November 11, 2004
Filing Date:
February 04, 2004
Export Citation:
Assignee:
SCHERING CORP (US)
CUA DANIEL J (US)
CHEN YI (US)
KASTELEIN ROBERT A (US)
LANGRISH CLAIRE L (US)
RENNICK DONNA M (US)
SEDGWICK JONATHON (US)
CUA DANIEL J (US)
CHEN YI (US)
KASTELEIN ROBERT A (US)
LANGRISH CLAIRE L (US)
RENNICK DONNA M (US)
SEDGWICK JONATHON (US)
International Classes:
A61P25/00; A61P29/00; C07K14/54; C12N5/08; A61K38/00; (IPC1-7): A61K31/713; A61K38/17; A61K39/395; A61P25/00; A61P29/00; C12N5/08
Domestic Patent References:
| WO2001085790A2 | 2001-11-15 | |||
| WO2004042009A2 | 2004-05-21 |
Other References:
BENSON J ET AL: "The role of IL-23 in experimental autoimmune encephalomyelitis", FASEB JOURNAL, vol. 16, no. 5, 22 March 2002 (2002-03-22), pages A1045, XP002971970, ISSN: 0892-6638
MURPHY CRAIG A ET AL: "Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation.", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 198, no. 12, 15 December 2003 (2003-12-15), pages 1951 - 1957, XP002294202, ISSN: 0022-1007
STALLMACH ANDREAS ET AL: "IL-23- but not IL-18-transcripts were increased in patients with inflammatory bowel disease (IBD)", GASTROENTEROLOGY, vol. 122, no. 4 Suppl. 1, April 2002 (2002-04-01), pages A264 - A265, XP008034555, ISSN: 0016-5085
AGGARWAL SUDEEPTA ET AL: "Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 3, 17 January 2003 (2003-01-17), pages 1910 - 1914, XP002294203, ISSN: 0021-9258
CUA D J ET AL: "Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain", NATURE, vol. 421, 13 February 2003 (2003-02-13), pages 744 - 748, XP002971969, ISSN: 0028-0836
LI JIFEN ET AL: "Differential expression and regulation of IL-23 and IL-12 subunits and receptors in adult mouse microglia.", JOURNAL OF THE NEUROLOGICAL SCIENCES, vol. 215, no. 1-2, 15 November 2003 (2003-11-15), pages 95 - 103, XP002294204, ISSN: 0022-510X
MURPHY CRAIG A ET AL: "Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation.", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 198, no. 12, 15 December 2003 (2003-12-15), pages 1951 - 1957, XP002294202, ISSN: 0022-1007
STALLMACH ANDREAS ET AL: "IL-23- but not IL-18-transcripts were increased in patients with inflammatory bowel disease (IBD)", GASTROENTEROLOGY, vol. 122, no. 4 Suppl. 1, April 2002 (2002-04-01), pages A264 - A265, XP008034555, ISSN: 0016-5085
AGGARWAL SUDEEPTA ET AL: "Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 3, 17 January 2003 (2003-01-17), pages 1910 - 1914, XP002294203, ISSN: 0021-9258
CUA D J ET AL: "Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain", NATURE, vol. 421, 13 February 2003 (2003-02-13), pages 744 - 748, XP002971969, ISSN: 0028-0836
LI JIFEN ET AL: "Differential expression and regulation of IL-23 and IL-12 subunits and receptors in adult mouse microglia.", JOURNAL OF THE NEUROLOGICAL SCIENCES, vol. 215, no. 1-2, 15 November 2003 (2003-11-15), pages 95 - 103, XP002294204, ISSN: 0022-510X
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