Title:
UTILISATION OF DIALKYLFUMARATES FOR TREATING HOST-VERSUS-GRAFT REACTIONS AND AUTO-IMMUNE DISEASES
Document Type and Number:
WIPO Patent Application WO2000030622
Kind Code:
A3
Abstract:
The invention relates to the utilisation of certain dialkylfumarates for producing pharmaceutical preparations for use in transplantation medicine or in the therapy of auto-immune deficiencies and to preparations in the form of micro-tablets or pellets. To this end, said dialkylfumarates can also be used in combination with conventional preparations in the field of transplantation medicine and conventional immunosuppressives, especially cyclosporines.
Inventors:
JOSHI RAJENDRA K (CH)
STREBEL HANS-PETER (CH)
STREBEL HANS-PETER (CH)
Application Number:
PCT/EP1999/008215
Publication Date:
November 02, 2000
Filing Date:
October 29, 1999
Export Citation:
Assignee:
FUMAPHARM AG (CH)
JOSHI RAJENDRA K (CH)
STREBEL HANS PETER (CH)
JOSHI RAJENDRA K (CH)
STREBEL HANS PETER (CH)
International Classes:
A61K9/16; A61K9/20; A61K9/28; A61K9/48; A61K31/125; A61K31/194; A61K31/225; A61P1/00; A61P1/16; A61P3/10; A61P5/14; A61P7/06; A61P17/00; A61P17/06; A61P19/02; A61P37/02; A61P37/06; (IPC1-7): A61K31/194; A61P37/06
Foreign References:
| CA2248955A1 | 1997-05-20 | |||
| EP0312697A2 | 1989-04-26 | |||
| DE2530372A1 | 1977-01-13 | |||
| EP0188749A2 | 1986-07-30 |
Other References:
HUNZIKER T. ET AL: "[Is psoriasis an autoimmune disease?]. PSORIASIS, EINE AUTOIMMUNKRANKHEIT ?.", THERAPEUTISCHE UMSCHAU, (1993) 50/2 (110-113)., XP002088941
M BACHARACH-BUHLES ET AL: "Fumaric Acid Esters (FAEs) Suppress CD 15- and ODP 4-positive Cells in Psoriasis", ACTA DERMATO-VENEREOLOGICA,XX,XX, no. SUPPL. 186, 16 September 1994 (1994-09-16), pages 79 - 82, XP002088940, ISSN: 0001-5555
H M OCKENFELS ET AL: "The antipsoriatic agent dimethylfumarate immunomodulates T-cell cytokine secretion and inhibits cytokines of the psoriatic cytokine network", BRITISH JOURNAL OF DERMATOLOGY,XX,XX, vol. 139, no. 3, 1 September 1998 (1998-09-01), pages 390 - 395, XP002089713, ISSN: 0007-0963
"merck manual", 1987, MERCK, XP002141006
M BACHARACH-BUHLES ET AL: "Fumaric Acid Esters (FAEs) Suppress CD 15- and ODP 4-positive Cells in Psoriasis", ACTA DERMATO-VENEREOLOGICA,XX,XX, no. SUPPL. 186, 16 September 1994 (1994-09-16), pages 79 - 82, XP002088940, ISSN: 0001-5555
H M OCKENFELS ET AL: "The antipsoriatic agent dimethylfumarate immunomodulates T-cell cytokine secretion and inhibits cytokines of the psoriatic cytokine network", BRITISH JOURNAL OF DERMATOLOGY,XX,XX, vol. 139, no. 3, 1 September 1998 (1998-09-01), pages 390 - 395, XP002089713, ISSN: 0007-0963
"merck manual", 1987, MERCK, XP002141006
Download PDF:
Previous Patent: PRESSURE-SENSITIVE ADHESIVE GEL COMPOSITION FOR IONTOPHORESIS AND APPARATUS THEREFOR
Next Patent: AGENT FOR LOWERING PROLACTIN
Next Patent: AGENT FOR LOWERING PROLACTIN