Title:
VACCINE AGAINST STREPTOCOCCUS PNEUMONIAE CAPSULAR POLYSACCHARIDES
Document Type and Number:
WIPO Patent Application WO2000056358
Kind Code:
A3
Abstract:
The present invention relates to the field of bacterial polysaccharide antigen vaccines. In particular the present invention relates to specific advantageous pneumococcal polysaccharide conjugates adjuvanted with 3D-MPL and substantially devoid of aluminium-based adjuvant.
Inventors:
CAPIAU CARINE (BE)
DESCHAMPS MARGUERITE (BE)
DESMONS PIERRE MICHEL (BE)
LAFERRIERE CRAIG ANTONY JOSEPH (BE)
POOLMAN JAN (BE)
PRIEELS JEAN-PAUL (BE)
DESCHAMPS MARGUERITE (BE)
DESMONS PIERRE MICHEL (BE)
LAFERRIERE CRAIG ANTONY JOSEPH (BE)
POOLMAN JAN (BE)
PRIEELS JEAN-PAUL (BE)
Application Number:
PCT/EP2000/002465
Publication Date:
January 04, 2001
Filing Date:
March 17, 2000
Export Citation:
Assignee:
SMITHKLINE BEECHAM BIOLOG (BE)
CAPIAU CARINE (BE)
DESCHAMPS MARGUERITE (BE)
DESMONS PIERRE MICHEL (BE)
LAFERRIERE CRAIG ANTONY JOSEPH (BE)
POOLMAN JAN (BE)
PRIEELS JEAN PAUL (BE)
CAPIAU CARINE (BE)
DESCHAMPS MARGUERITE (BE)
DESMONS PIERRE MICHEL (BE)
LAFERRIERE CRAIG ANTONY JOSEPH (BE)
POOLMAN JAN (BE)
PRIEELS JEAN PAUL (BE)
International Classes:
A61K39/09; A61K35/74; A61K39/005; A61K39/02; A61K39/04; A61K39/05; A61K39/085; A61K39/095; A61K39/102; A61K39/112; A61K39/116; A61K39/155; A61K39/385; A61K39/39; A61P11/00; A61P27/06; A61P31/04; A61P37/04; C07K14/285; C12N15/09; A61K39/00; A61K; A61P; (IPC1-7): A61K39/09; A61K39/39; A61K39/385; A61P31/04
Domestic Patent References:
| WO1990006951A1 | 1990-06-28 | |||
| WO1998051339A1 | 1998-11-19 | |||
| WO1996032963A1 | 1996-10-24 | |||
| WO1995017209A1 | 1995-06-29 | |||
| WO1996033739A1 | 1996-10-31 | |||
| WO1999033488A2 | 1999-07-08 |
Foreign References:
| US4912094A | 1990-03-27 |
Other References:
DERMODY K M ET AL: "Evaluation of monophosphoryl lipid A as a vaccine adjuvant, for a multivalent pneumococcal glycoconjugate vaccine in mice.", FASEB JOURNAL, vol. 12, no. 4, 17 March 1998 (1998-03-17), pages A612, XP002149960, ISSN: 0892-6638
SCHNEERSON R ET AL: "EVALUATION OF MONOPHOSPHORYL LIPID A MPL AS AN ADJUVANT ENHANCEMENT OF THE SERUM ANTIBODY RESPONSE IN MICE TO POLYSACCHARIDE-PROTEIN CONJUGATES BY CONCURRENT INJECTION WITH MPL", JOURNAL OF IMMUNOLOGY, vol. 147, no. 7, 1991, pages 2136 - 2140, XP002149961, ISSN: 0022-1767
KUO JOSEPH ET AL: "Adjuvant monophosphoryl lipid A enhances the antibody response and protection against heterologous challenge with S. pneumoniae type 6A in mice vaccinated with pneumococcal type 18C polysaccharide-recombinant pneumolysin conjugates.", ABSTRACTS OF THE INTERSCIENCE CONFERENCE ON ANTIMICROBIAL AGENTS AND, vol. 36, 1996, 36th ICAAC;New Orleans, Louisiana, USA; September 15-18, 1996, 1996, pages 162, XP000946853
MICHON F ET AL: "Multivalent pneumococal capsular polysaccharide conjugate vaccines employing genetically detoxified pneumolysin as a carrier protein", VACCINE,GB,BUTTERWORTH SCIENTIFIC. GUILDFORD, vol. 16, no. 18, 1998, pages 1732 - 1741, XP002089380, ISSN: 0264-410X
LEE C J ET AL: "Immunologic epitope, gene, and immunity involved in pneumococcal glycoconjugate.", CRITICAL REVIEWS IN MICROBIOLOGY, vol. 23, no. 2, 1997, pages 121 - 142, XP000946772
MUSHER DANIEL M ET AL: "IgG responses to protein-conjugated pneumococcal capsular polysaccharides in persons who are genetically incapable of responding to unconjugated polysaccharides.", CLINICAL INFECTIOUS DISEASES, vol. 27, no. 6, December 1998 (1998-12-01), pages 1487 - 1490, XP000946755, ISSN: 1058-4838
SCHNEERSON R ET AL: "EVALUATION OF MONOPHOSPHORYL LIPID A MPL AS AN ADJUVANT ENHANCEMENT OF THE SERUM ANTIBODY RESPONSE IN MICE TO POLYSACCHARIDE-PROTEIN CONJUGATES BY CONCURRENT INJECTION WITH MPL", JOURNAL OF IMMUNOLOGY, vol. 147, no. 7, 1991, pages 2136 - 2140, XP002149961, ISSN: 0022-1767
KUO JOSEPH ET AL: "Adjuvant monophosphoryl lipid A enhances the antibody response and protection against heterologous challenge with S. pneumoniae type 6A in mice vaccinated with pneumococcal type 18C polysaccharide-recombinant pneumolysin conjugates.", ABSTRACTS OF THE INTERSCIENCE CONFERENCE ON ANTIMICROBIAL AGENTS AND, vol. 36, 1996, 36th ICAAC;New Orleans, Louisiana, USA; September 15-18, 1996, 1996, pages 162, XP000946853
MICHON F ET AL: "Multivalent pneumococal capsular polysaccharide conjugate vaccines employing genetically detoxified pneumolysin as a carrier protein", VACCINE,GB,BUTTERWORTH SCIENTIFIC. GUILDFORD, vol. 16, no. 18, 1998, pages 1732 - 1741, XP002089380, ISSN: 0264-410X
LEE C J ET AL: "Immunologic epitope, gene, and immunity involved in pneumococcal glycoconjugate.", CRITICAL REVIEWS IN MICROBIOLOGY, vol. 23, no. 2, 1997, pages 121 - 142, XP000946772
MUSHER DANIEL M ET AL: "IgG responses to protein-conjugated pneumococcal capsular polysaccharides in persons who are genetically incapable of responding to unconjugated polysaccharides.", CLINICAL INFECTIOUS DISEASES, vol. 27, no. 6, December 1998 (1998-12-01), pages 1487 - 1490, XP000946755, ISSN: 1058-4838
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