VASCULAR ENDOTHELIAL GROWTH FACTOR-X - JANSSEN PHARMACEUTICA NV

Title:

VASCULAR ENDOTHELIAL GROWTH FACTOR-X

Document Type and Number:

WIPO Patent Application WO2000037641

Kind Code:

A3

Abstract:

There is provided a novel vascular endothelial growth factor, herein designated VEGF-X, in addition to the nucleic acid molecule encoding it, a host cell transformed with said vector and compounds which inhibit or enhance angiogenesis. Also provided is the sequence of a CUB domain present in the sequence of VEGF-X which domain itself prevents angiogenesis and which is used to treat diseases associated with inappropriate vascularisation or angiogenesis.

Inventors:

GORDON ROBERT DOUGLAS (BE)
SPRENGEL JORG JURGEN (BE)
YON JEFFREY ROLAND (BE)
DIJKMANS JOSIENA JOHANNA HUBER (BE)
GOSIEWSKA ANNA (US)
DHANARAJ SRIDEVI NAIDU (US)
XU JEAN (US)

Application Number:

PCT/US1999/030503

Publication Date:

October 19, 2000

Filing Date:

December 21, 1999

Export Citation:

Click for automatic bibliography generation Help

Assignee:

JANSSEN PHARMACEUTICA NV (BE)
GORDON ROBERT DOUGLAS (BE)
SPRENGEL JORG JURGEN (BE)
YON JEFFREY ROLAND (BE)
DIJKMANS JOSIENA JOHANNA HUBER (BE)
GOSIEWSKA ANNA (US)
DHANARAJ SRIDEVI NAIDU (US)
XU JEAN (US)

International Classes:

A61P9/00; C07K14/52; C12N1/21; C12N15/12; A61K38/00; (IPC1-7): C12N15/12; C12N5/10; C12N1/21; C07K14/52; C07K16/22; G01N33/50; G01N33/566; A01K67/027; A61K31/70; A61K38/18; A61K39/395; A61P9/00

Domestic Patent References:

WO1999047677A2	1999-09-23
WO1999037671A1	1999-07-29
WO1998007832A1	1998-02-26
WO1998024811A2	1998-06-11

Foreign References:

EP0984063A2

2000-03-08

Download PDF:

View/Download PDF PDF Help

Previous Patent: COMPOSITIONS AND METHODS FOR THE TREATMENT OF TUMOR

Next Patent: METHOD OF ENHANCING THE BIOLOGICAL ACTIVITY OF LIGANDS