Title:
VECTOR GENETICALLY ENGINEERED WITH CHIMERIC ANTIGEN RECEPTOR AND AGAINST TWO OR MORE TARGETS AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/089656
Kind Code:
A1
Abstract:
Provided are a vector genetically engineered with a chimeric antigen receptor and against two or more targets for combined treatment of diseases such as human tumors, a related immune cell and an application thereof. The vector genetically engineered with a chimeric antigen receptor and the related immune cell have enhanced ability to kill target cells.
Inventors:
LI BENSHANG (CN)
WANG TIANYI (CN)
WAN XINYU (CN)
YANG XIAOMIN (CN)
WANG TIANYI (CN)
WAN XINYU (CN)
YANG XIAOMIN (CN)
Application Number:
PCT/CN2021/128240
Publication Date:
May 05, 2022
Filing Date:
November 02, 2021
Export Citation:
Assignee:
SPH BIOTHERAPEUTICS SHANGHAI LTD (CN)
International Classes:
C12N15/62; A61P35/00; C12N5/10; C12N15/79
Domestic Patent References:
| WO2017165245A2 | 2017-09-28 | |||
| WO2016200822A1 | 2016-12-15 | |||
| WO2020123691A2 | 2020-06-18 |
Foreign References:
| CN108220247A | 2018-06-29 |
Other References:
CHU SU-XIA , YAO LUN-GUANG , XING YAN-HAO, ZHOU YAN-QING: "Advances on the Study of Multi-gene Expression System", CHINA BIOTECHNOLOGY, vol. 31, no. 6, 15 June 2011 (2011-06-15), pages 116 - 123, XP055810954, ISSN: 1671-8135, DOI: 10.13523/j.cb.20110619
GHEYBI ELAHEH, AMANI JAFAR, SALMANIAN ALI HATEF, MASHAYEKHI FARHAD, KHODI SAMANEH: "Designing a recombinant chimeric construct contain MUC1 and HER2 extracellular domain for prediagnostic breast cancer", TUMOR BIOLOGY, vol. 35, no. 11, 1 November 2014 (2014-11-01), CH , pages 11489 - 11497, XP055925026, ISSN: 1010-4283, DOI: 10.1007/s13277-014-2483-y
GHEYBI ELAHEH, AMANI JAFAR, SALMANIAN ALI HATEF, MASHAYEKHI FARHAD, KHODI SAMANEH: "Designing a recombinant chimeric construct contain MUC1 and HER2 extracellular domain for prediagnostic breast cancer", TUMOR BIOLOGY, vol. 35, no. 11, 1 November 2014 (2014-11-01), CH , pages 11489 - 11497, XP055925026, ISSN: 1010-4283, DOI: 10.1007/s13277-014-2483-y
Attorney, Agent or Firm:
SHANGHAI DIANSHI PARTNERS, P.C. (CN)
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