Title:
VIRAL RECEPTOR-DERIVED PEPTIDES AGAINST VIRAL DISEASES
Document Type and Number:
WIPO Patent Application WO/2023/164026
Kind Code:
A3
Abstract:
The present disclosure provides novel computational methods for identifying potential therapeutic peptides as antivirals, and methods of using viral receptor-derived peptides as antivirals. Further, the present disclosure provides methods of using angiotensin converting enzyme 2 (ACE2)-derived peptides as therapeutic treatments for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-caused coronavirus disease 2019 (COVID-19).
Inventors:
TENG SHAOLEI (US)
TANG QIYI (US)
TANG QIYI (US)
Application Number:
PCT/US2023/013671
Publication Date:
October 19, 2023
Filing Date:
February 23, 2023
Export Citation:
Assignee:
UNIV HOWARD (US)
International Classes:
A61K38/48; A61P31/14; G01N33/53; G16B20/50; C12N9/48
Domestic Patent References:
| WO2021188966A1 | 2021-09-23 | |||
| WO2022165245A1 | 2022-08-04 |
Foreign References:
| CN112538494A | 2021-03-23 |
Other References:
CHAN ET AL.: "Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2", SCIENCE, vol. 369, no. 6508, 4 September 2020 (2020-09-04), pages 1261 - 1265, XP055892404, DOI: 10.1126/science.abc0870
LAURINI ET AL.: "Computational Mutagenesis at the SARS-CoV-2 Spike Protein/Angiotensin-Converting Enzyme 2 Binding Interface: Comparison with Experimental Evidence", ACS NANO, vol. 15, 18 March 2021 (2021-03-18), pages 6929 - 6948, XP055858965, DOI: 10.1021/acsnano.0c10833
FARHOUDI RAMIN, TAHERI MOHAMMAD, SOLTANI MINOO, NEZHAD FARD RAMINMAZAHERI, SHAHEDIN GOLSHIDJAVDANI, NABIAN SEDIGHEH: "Rational design of a hybrid peptide against severe acute respiratory syndrome coronavirus 2 using melittin and angiotensin-converting enzyme 2 as pharmaceutical agents", ADVANCED BIOMEDICAL RESEARCH, vol. 11, no. 1, 1 January 2022 (2022-01-01), pages 88, XP093102449, ISSN: 2277-9175, DOI: 10.4103/abr.abr_341_21
RHOADES RAINA, SOBITAN ADEBIYI, MAHASE VIDHYANAND, GEBREMEDHIN BRHAN, TANG QIYI, RAWAT DANDA, CAO HONGBAO, TENG SHAOLEI: "In-silico investigation of systematic missense mutations of middle east respiratory coronavirus spike protein", FRONTIERS IN MOLECULAR BIOSCIENCES, vol. 9, XP093102451, DOI: 10.3389/fmolb.2022.933553
LAURINI ET AL.: "Computational Mutagenesis at the SARS-CoV-2 Spike Protein/Angiotensin-Converting Enzyme 2 Binding Interface: Comparison with Experimental Evidence", ACS NANO, vol. 15, 18 March 2021 (2021-03-18), pages 6929 - 6948, XP055858965, DOI: 10.1021/acsnano.0c10833
FARHOUDI RAMIN, TAHERI MOHAMMAD, SOLTANI MINOO, NEZHAD FARD RAMINMAZAHERI, SHAHEDIN GOLSHIDJAVDANI, NABIAN SEDIGHEH: "Rational design of a hybrid peptide against severe acute respiratory syndrome coronavirus 2 using melittin and angiotensin-converting enzyme 2 as pharmaceutical agents", ADVANCED BIOMEDICAL RESEARCH, vol. 11, no. 1, 1 January 2022 (2022-01-01), pages 88, XP093102449, ISSN: 2277-9175, DOI: 10.4103/abr.abr_341_21
RHOADES RAINA, SOBITAN ADEBIYI, MAHASE VIDHYANAND, GEBREMEDHIN BRHAN, TANG QIYI, RAWAT DANDA, CAO HONGBAO, TENG SHAOLEI: "In-silico investigation of systematic missense mutations of middle east respiratory coronavirus spike protein", FRONTIERS IN MOLECULAR BIOSCIENCES, vol. 9, XP093102451, DOI: 10.3389/fmolb.2022.933553
Attorney, Agent or Firm:
TAKAGI, Keiko K. et al. (US)
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