WHITENING AGENT, HYALURONIC ACID PRODUCTION PROMOTER, COLLAGEN PRODUCTION PROMOTER, INTRACELLULAR ACTIVE OXYGEN SCAVENGER, IRRITATION MITIGATOR, WRINKLE-AMELIORATING AGENT, COMPLEX, COSMETIC AND EXTERNAL PREPARATION FOR SKIN

Title:

Document Type and Number:

WIPO Patent Application WO/2020/137017

Kind Code:

A1

Abstract:

The present invention provides new uses of phosphatidylinositol. Further, the present invention provides a composition capable of easily and stably dispersing phosphatidylinositol in water and a technique whereby phosphatidylinositol can be easily and stably dispersed in water.　Phosphatidylinositol (PI), in particular, a PI-rich composition produced by a specific method can be used as a whitening agent, a hyaluronic acid production promoter, a collagen production promoter, an intracellular active oxygen scavenger, an irritation mitigator and a wrinkle-ameliorating agent.　The problem of the present invention can be solved by: a complex obtained by, from a solution in which component (A1) which is phosphatidylinositol, component (A2) which is lecithin and component (A3) which is a sterol are homogeneously dissolved in an organic solvent, removing the organic solvent and thus simultaneously precipitating components (A1) to (A3); and a cosmetic or an external preparation for skin which contains, as essential components, component (A) which is a composition comprising phosphatidylinositol and lecithin, component (B) which is a polyhydric alcohol and component (C) which is water.

Inventors:

KOTERA HIROKI (JP)
NIKI YOKO (JP)
KOYAMA MIHO (JP)
KATSUMATA YUKI (JP)
HASHIMOTO AKIHIRO (JP)
ENDO KARIN (JP)
UEDA TAKESHI (JP)
OHASHI YUKIHIRO (JP)

Application Number:

PCT/JP2019/035511

Publication Date:

July 02, 2020

Filing Date:

September 10, 2019

Export Citation:

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Assignee:

NIPPON FINE CHEMICAL CO (JP)

International Classes:

A61K8/60; A61K31/23; A61K31/661; A61K31/683; A61K31/685; A61K31/704; A61P17/00; A61P17/18; A61P39/00; A61P39/06; A61P43/00; A61Q17/00; A61Q19/00; A61Q19/02; A61Q19/08; C12P19/04

Domestic Patent References:

WO2009110205A1	2009-09-11
WO2009028220A1	2009-03-05
WO2007010892A1	2007-01-25

Foreign References:

JP2008260743A	2008-10-30
JP2004231544A	2004-08-19
JP2017178789A	2017-10-05
JP2010120885A	2010-06-03
JP2015027260A	2015-02-12
JPS60246305A	1985-12-06

Other References:

TRISCOTT, M. X. ET AL.: "Solubilization of Hyaluronic Acid Synthetic Activity from Streptococci and Its Activation with Phospholipids", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 261, no. 13, 5 May 1986 (1986-05-05), pages 6004 - 6009, XP008140934
LABORATOIRES DERMATOLOGIQUES URIAGE , RICH WRINKLE FOCUS CORRECTION CREAM , MINTEL GNPD, February 2012 (2012-02-01), Retrieved from the Internet [retrieved on 20191001]