Title:
$g(b)-AMYLOID FORMATION INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2000/024392
Kind Code:
A1
Abstract:
Compounds represented by the following general formula which are useful in treating Alzheimer's disease, etc. because of having an effect of inhibiting the formation of $g(b)-amyloid: R?1¿-Y-NH-A-CO-R?2¿ wherein R?1¿ represents optionally substituted aryl, an optionally substituted unsaturated heterocycle or optionally substituted alkyl; R?2¿ represents optionally substituted amino, optionally substituted alkoxy or hydroxy; -Y- represents -CO-, etc.; and -A- represents a group of formula (I), etc. wherein one of R?3¿ and R?4¿ represents hydrogen, halogeno, -S(O)¿n?-X (wherein n is 0, 1 or 2; and X represents optionally substituted alkyl, optionally substituted aryl or an optionally substituted unsaturated heterocycle), optionally substituted alkyl or optionally substituted aryl, while the other one of R?3¿ and R?4¿ represents optionally substituted aryl or an optionally substituted unsaturated heterocycle.
Inventors:
KOJIMA SHINICHI (JP)
TSUTSUMI YASUSHI (JP)
YAMAGA HIROSHI (JP)
NISHIHARA TOSHIO (JP)
TOYODA TOMOHIRO (JP)
ITO AKIRA (JP)
TSUTSUMI YASUSHI (JP)
YAMAGA HIROSHI (JP)
NISHIHARA TOSHIO (JP)
TOYODA TOMOHIRO (JP)
ITO AKIRA (JP)
Application Number:
PCT/JP1999/005871
Publication Date:
May 04, 2000
Filing Date:
October 25, 1999
Export Citation:
Assignee:
SUMITOMO PHARMA (JP)
KOJIMA SHINICHI (JP)
TSUTSUMI YASUSHI (JP)
YAMAGA HIROSHI (JP)
NISHIHARA TOSHIO (JP)
TOYODA TOMOHIRO (JP)
ITO AKIRA (JP)
KOJIMA SHINICHI (JP)
TSUTSUMI YASUSHI (JP)
YAMAGA HIROSHI (JP)
NISHIHARA TOSHIO (JP)
TOYODA TOMOHIRO (JP)
ITO AKIRA (JP)
International Classes:
A61P25/28; C07C233/87; C07D277/44; C07D277/46; (IPC1-7): A61K31/165; A61K31/166; A61K31/167; A61K31/197; A61K31/216; A61K31/40; A61K31/415; A61K31/425; A61K31/44; A61K31/445; A61K31/47; A61K31/495; A61K31/505; A61K31/695; A61P25/28; C07C233/87; C07C237/22; C07D209/16; C07D211/58; C07D213/56; C07D213/70; C07D213/74; C07D215/38; C07D231/38; C07D239/26; C07D241/12; C07D277/44; C07D417/12; C07F7/18
Domestic Patent References:
| WO1996039194A1 | 1996-12-12 | |||
| WO1998026773A1 | 1998-06-25 | |||
| WO1998004278A2 | 1998-02-05 | |||
| WO1997003783A1 | 1997-02-06 | |||
| WO1998033501A1 | 1998-08-06 | |||
| WO1997010816A1 | 1997-03-27 | |||
| WO1996025161A1 | 1996-08-22 |
Foreign References:
| US5021439A | 1991-06-04 | |||
| EP0284632A1 | 1988-10-05 | |||
| US5523314A | 1996-06-04 | |||
| US5552426A | 1996-09-03 |
Other References:
HASSAN H.M. ET AL.: "Synthesis and antimicrobial activity of some new N-aminoacyl derivatives of 2-amino-4-phenylthia-zole", ACTA PHARM.,, vol. 47, no. 3, 1997, (ZAGREB), pages 159 - 166, XP002923136
HANNA M.M. ET AL.: "Synthesis and antimicrobial activity of some substituted 3-aryl-5- benzylidene-2-phenyl-4-imida-zolone derivatives", BULL. FAC. PHARM.,, vol. 32, no. 3, 1994, (CAIRO UNIV.), pages 353 - 359, XP002923137
KANDEEL ZAGHLOUL E. ET AL.: "Studies with polyfunctionally substituted heterocycles. Novel synthesis of pyrazolo(1,5-a)pyrimidine, triazolo(1,5-a)pyrimidine and pyranooxazole derivatives", J. CHEM. RES. SYNOP.,, no. 11, 1994, pages 416 - 417, XP000892866
GOMMAA A.M. ET AL.: "Synthesis of some new substituted aminoacylthiazoles and dipeptide derivatives", ASIAN J. CHEM.,, vol. 4, no. 3, 1992, pages 527 - 533, XP002923138
EL-NAGGAR A.M. ET AL.: "Synthesis of some 2-(N-tosyl- or N-phthalyol-aminoacyl)aminopyridines and 2-(N-tosyl- or N-phthaloylaminoacyl)aminothiazoles", INDIAN J. CHEM. SECT. B,, vol. 15B, no. 9, 1977, pages 850 - 852, XP002923139
HANNA M.M. ET AL.: "Synthesis and antimicrobial activity of some substituted 3-aryl-5- benzylidene-2-phenyl-4-imida-zolone derivatives", BULL. FAC. PHARM.,, vol. 32, no. 3, 1994, (CAIRO UNIV.), pages 353 - 359, XP002923137
KANDEEL ZAGHLOUL E. ET AL.: "Studies with polyfunctionally substituted heterocycles. Novel synthesis of pyrazolo(1,5-a)pyrimidine, triazolo(1,5-a)pyrimidine and pyranooxazole derivatives", J. CHEM. RES. SYNOP.,, no. 11, 1994, pages 416 - 417, XP000892866
GOMMAA A.M. ET AL.: "Synthesis of some new substituted aminoacylthiazoles and dipeptide derivatives", ASIAN J. CHEM.,, vol. 4, no. 3, 1992, pages 527 - 533, XP002923138
EL-NAGGAR A.M. ET AL.: "Synthesis of some 2-(N-tosyl- or N-phthalyol-aminoacyl)aminopyridines and 2-(N-tosyl- or N-phthaloylaminoacyl)aminothiazoles", INDIAN J. CHEM. SECT. B,, vol. 15B, no. 9, 1977, pages 850 - 852, XP002923139
Attorney, Agent or Firm:
Asamura, Kiyoshi (New Ohtemachi Building 2-1 Ohtemachi 2-chome Chiyoda-ku, Tokyo, JP)
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