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WO/2000/024734A1 |
This invention relates to the identification of a novel class of therapeutic agents which selectively target and kill tumor cells and certain other types of diseased cells, and to compositions comprising lipoic acid derivatives which poi...
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WO/2000/024711A1 |
This invention encompasses a novel process for synthesizing compounds represented by formula (A). These compounds are intermediates useful in the preparation of certain agents that are selective COX-2 inhibitors.
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WO/2000/024697A1 |
Aldehyde derivatives of polyethylene glycols and methods of making thereof are disclosed. These aldehyde derivatives can be used to make polyethylene glycol-hydrazines, polyethylene glycol-thiols, polyethylene glycol amines, and branched...
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WO1999063933A9 |
Disclosed are multibinding compounds which are agonists, partial agonists, inverse agonists, partial inverse agonist or antagonists of the GABA receptors, which are involved in neurological disorders. The multibinding compounds of this i...
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WO/2000/023407A2 |
Novel compounds of Formula (1) and esters, salts, and physiologically functional derivatives thereof are disclosed. Methods for preparing and using the compounds are also disclosed. Many of these compounds are selective activators of PPA...
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WO/2000/023409A1 |
A method is provided for synthesizing diaryl-substituted heterocyclic compounds, particularly 2,5-diaryl-substituted tetrahydrofurans and tetrahydrothiophenes. Methods for synthesizing starting materials and intermediates are provided as...
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WO1999064000A9 |
Novel multi-binding compounds (agents) which bind neurokinin receptors are used to treat disorders in mammals that are mediated by the neurokinin receptors, such as Parkinson's disease, Alzheimer's disease, depression, anxiety, inflammat...
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WO/2000/021924A1 |
The invention relates to benzocyclohexandiones of general formula (I), a method for the production and use thereof as herbicides and plant growth regulators. In said general formula (I), R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿ and R?7¿...
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WO/2000/021920A1 |
Compounds of the formula (1a), wherein R1 is a group of the formula (2) where R1, R2, A, B, U, V, W, X, Y, Z, k and n have the significance given in the specification, are useful to treat rheumatoid arthritis, psoriasis, multiple scleros...
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WO/2000/021925A1 |
Oxidative stress-inhibitory agents which inhibit the expression of wound proteins and the activation of gene transcriptional regulatory factors relating thereto and show a good feel in using and a high safety; a method for preventing, re...
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WO/2000/020389A1 |
A compound having formula (I) wherein R?1¿ is oxo, -OR?a¿, -OC(=O)R?b¿; or (A); R?2¿ is H; or R?1¿ is -OR?c¿ and R?2¿ is -OR?d¿; or R?1¿ and R?2¿ together form -O(CH¿2?)¿m?O-; and any pharmaceutically-acceptable salt thereof ...
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WO/2000/020371A1 |
Compounds and methods for treating prostaglandin mediated diseases, and certain pharmaceutical compositions thereof are disclosed. The compounds are represented by formula (II): Ar?1¿-W-Ar?2¿-X-Q. The compounds of the invention are str...
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WO/2000/020385A1 |
Novel glutathione reductase activity intensifiers, which are compounds having general formula (I) and pharmacologically acceptable salts, thioesters, and other derivatives thereof, wherein m is 0 or 1; n is 2 when m is 0, and n is 1 when...
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WO/2000/018724A1 |
The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, ...
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WO/2000/018727A1 |
Compounds represented by general formula (1) which are intermediates useful in producing oxime ether compounds being highly efficacious as agricultural/horticultural germicides wherein R?1¿ represents alkyl, alkenyl, alkynyl, cycloalkyl...
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WO/2000/018721A1 |
The invention relates to substituted polycyclic aryl and heteroaryl $i(tertiary)-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions an...
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WO/2000/016772A1 |
The present invention provides an antiproliferative compound having structural formula (I), wherein X is oxygen, nitrogen or sulfur; R?1¿ is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, carboxamide, ester, th...
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WO2000000483A9 |
Novel tubulin binding compounds having potent tubulin depolymerization activity and inhibitory activity against tubulin polymerization. The compounds are effective agents for inhibiting cellular proliferation, for example, in cancer cell...
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WO/2000/016766A1 |
A medical composition containing, as an active constituent, a nitroetheneamine derivative represented by formula (I) wherein R?1¿ is a hydrogen atom, an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, aryl or h...
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WO/2000/017133A2 |
The invention concerns LTA¿4? hydrolase inhibiting compounds of formula (I). It also concerns their therapeutic, in particular anti-inflammatory, applications.
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WO/2000/015603A1 |
Benzene derivatives represented by general formula (I) or pharmaceutically acceptable salts thereof; and AP-1 activation inhibitors, NF-kappa B activation inhibitors, inflammatory cytokine production inhibitors, matrix metalloprotease pr...
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WO/2000/015606A1 |
The invention relates to new substituted N-aryl-O-alkyl-carbamates of general formula (I) in which Ar?1¿ is an, in each case possibly substituted, monocyclic or bicyclic, carbocyclic or heterocyclic group from the series phenyl, naphthy...
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WO/2000/015614A1 |
The invention relates to novel pyridyl derivatives (I), their use as medicaments, pharmaceutical formulations including them and methods for their preparation.
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WO/2000/015585A1 |
The invention concerns a method for the condensation of aromatic derivative(s) or a sulphinic derivative by a perhalogenated, advantageously perfluorinated, carbon atom. Said method is characterised in that it consists in subjecting said...
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WO1999063983A9 |
Disclosed are novel multi-binding compounds (agents) which bind to PPAR gamma receptors. The compounds of this invention comprise a plurality of ligands each of which can bind to such receptors thereby modulating the biological processes...
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WO/2000/015625A2 |
The present invention relates to methods of making dihydropyrone HIV protease inhibitors.
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WO1999064047A9 |
Novel compounds are disclosed, useful as antiviral agents.
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WO/2000/014060A1 |
A process for the preparation of aromatic thiols represented by the general formula (I): Y¿n?-Ar-(SH)¿m? (wherein Ar is an aromatic hydrocarbon residue; Y is at least one kind of substituent bonded to a carbon atom constituting the aro...
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WO1999063929A9 |
Disclosed are multibinding compounds which inhibit microsomal triglyceride transferase protein (MTP), a protein which mediates the transfer of lipids during the assembly of lipoproteins and related biomolecules. The multibinding compound...
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WO/2000/014059A1 |
The invention relates to a method for producing derivatives of 4-alkylsulfinyl methylarylene methanols. Derivatives of 4-alkylsulfinyl methylarylene methanols are valuable monomers in the production of conjugated polymers, which are suit...
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WO/2000/012462A1 |
This invention relates to new aminoalcohol derivatives or salts thereof represented by formula (I) wherein each symbol is as defined in the specification or salts thereof which have $g(b)¿3? adrenergic agonist activity and therefore hav...
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WO/2000/012469A1 |
This invention relates to novel compositions of matter which either terminate in a sulfhydryl moiety or are disulfides. The compounds also include a terminal sulfonate or phosphonate moiety, and have many uses, such as toxicity reducing ...
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WO1999064054A9 |
Disclosed are multibinding compounds which inhibit topoisomerases which are essential enzymes in higher encaryotes for DNA replication and repair. The multibinding compounds of this invention containing from 2 to 10 ligands covalently at...
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WO/2000/010971A1 |
The invention relates to novel substituted N-Aryl-O-alkyl-carbamates of general formula (I), in which: m represents the numbers 0, 1 or 2; n represents the numbers 0 or 1; Ar represents an optionally substituted, monocyclic or bicyclic, ...
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WO/2000/008033A1 |
The present invention is directed to novel water-soluble prodrugs of aliphatic or aromatic hindered hydroxyl group containing pharmaceuticals.
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WO/2000/008495A2 |
The present invention provides a compound selected from the group consisting of (I), (II), and (III), wherein R?1¿ and R?4¿ are the same or different and are each H, C¿1?-C¿3? alkyl, phosphate, or C¿1?-C¿3? alkyl carboxylate; R?2¿...
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WO/2000/006555A1 |
This invention provides a process for preparing compounds of formula (1) wherein: X is phenyl optionally substituted with one or more substituents selected from the group consisting of halogen, alkyl of 1-6 carbon atoms, alkoxy of 1-6 ca...
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WO/2000/006529A1 |
Diketoacids of Formula (A) are useful as inhibitors of viral polymerases. In particular hepatitis C virus RNA dependent RNA polymerase (HCV RdRp), hepatitis B virus polymerase (HBV pol) and reverse transcriptase of human immunodeficiency...
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WO/2000/006137A2 |
Compounds having Formula (I) are useful for modulating the glucocorticoid receptor in a mammal. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I) and methods of treating immune, autoimmune, inflammatory, ...
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WO/2000/006148A1 |
The present invention relates to the potentiation of glutamate receptor function using certain sulphonamide derivatives. It also relates to novel sulphonamide derivatives, to processes for their preparation and to pharmaceutical composit...
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WO/2000/006585A1 |
Nitric acid salts with medicines active in bony disorders.
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WO/2000/005198A1 |
Anthranilic acid derivatives represented by general formulae (1) or (2) (wherein Y?1¿ and Y?2¿ are each a group represented by general formula (3)-1, (3)-2 or the like; X?1¿ is O, S or the like; X?2¿ is O or S; and R?1¿ to R?4¿ are...
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WO/2000/003979A1 |
The invention relates to novel benzocycloheptenes of general formula (I), wherein R?1¿, R?2¿ and SK have the meanings cited in the description. The novel compounds exhibit a selective estrogenic activity on bones and are suitable for p...
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WO/2000/003976A1 |
The invention relates to novel imidamide derivatives of formula (I), wherein R, R?1¿, R?2¿ and R?3¿ have the meaning mentioned in the description. The invention also relates to a method of production and to the use of said derivatives...
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WO/2000/003978A2 |
The compounds of formula (I) act as inhibitors on ATP-sensitive potassium canals and are suitable for the treatment of cardio-vascular disorders, especially the treatment of arrhythmias, prevention of sudden death from heart disease or a...
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WO/2000/003975A2 |
The invention relates to aryl vinyl ether derivatives of general formula (I), wherein the substituents are as defined in the description; compositions containing them, processes and intermediates for their preparation and a method of con...
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WO/2000/002852A1 |
The invention concerns a novel method for preparing hydroxymethylthiobutyric acid by sulphuric hydrolysis of hydroxymethylthiobutyronitrile.
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WO/2000/002851A1 |
The present invention relates to compounds of formula (I), wherein A?1¿, A?2¿, R?1¿, R?2¿, R?3¿, X and n are as defined in the claims, which are valuable pharmaceutically active compounds for the therapy and prophylaxis of diseases,...
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WO/2000/002853A1 |
The invention concerns an improved method for separating hydroxymethylthiobutyric acid by neutralising hydroxymethylthiobutyronitrile sulphuric hydrolysate, decanting and treating each phase with an organic solvent.
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WO/2000/001668A2 |
The present invention relates to N-Acetylated $g(a)-Linked Acidic Dipeptidase (NAALADase) inhibitors enzyme activity, pharmaceutical compositions comprising such inhibitors, and methods of their use to inhibit NAALADase enzyme activity, ...
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