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WO/2001/077096A2 |
This invention relates to a process for the preparation of thioacetates addition of thioacetic acid or a salt thereof on $g(a)-,$g(b)-, or $g(g)-unsaturated alcohols, carbonyl compounds or cyclic or acyclic alkenes or by nucleophilic sub...
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WO/2001/076390A2 |
The invention relates to a process for flavouring foodstuffs by incorporating therein an effective amount of at least one compound R1-S-R2 with a specific, well defined structure such as (E)-2-methyl-1-(methylthio)-2-butene; S-ethyl thio...
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WO/2001/077359A2 |
This invention relates to the generation of natural flavouring thiols and their disulfides derivates by bioconversion and their use as enhancers or intensifiers of flavour in food product. The invention also relates to new aroma compound...
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WO/2001/074318A2 |
The invention relates to an agent for the durable forming of hair. The inventive agent is characterised in that said agent contains a compound of general formula (I) as the keratin-reducing active agent. R¿1? and R¿2?, independently fr...
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WO/2001/074770A1 |
The invention relates to novel C¿2? phenyl-substituted cyclic keto-enols of formula (I), in which W, X, Y, Z and CKE have the meanings as cited in the description. The invention also relates to methods for producing said C¿2? phenyl-su...
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WO/2001/072687A1 |
A compound of general formula (I), or pharmaceutically acceptable salts, solvates or polymorphs thereof; wherein R?3� is independ ently CF�3?, OCF�3?, C�1?-C�4?alkylthio or C�1?-C�4?alkoxy; n is 1, 2 or 3; and the other var...
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WO/2001/072702A2 |
The present invention relates to amidino compounds of formula (I), in which the variables are as defined in the claims, and salts thereof. In another embodiment the present invention also provides a use of the present compounds as nitric...
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WO/2001/072694A1 |
Zofimarin derivatives of the general formula (I), pharmacologically acceptable esters of the same, or salts thereof, exhibiting excellent antimycotic activity: (I) wherein X is formyl or cyano; and A is CH=N-O-R?a¿, -CH¿2?-S(=O)¿g?-R?...
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WO/2001/072703A1 |
The present invention relates to S-[2-(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine, or a pharmaceutically acceptable salt thereof.
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WO/2001/072888A1 |
The invention concerns the use, for increasing the life span of moulds made of silicone elastomer crosslinking by polyaddition or polycondensation reaction, of an additive capable of stabilising the silicone elastomer whereof the mould i...
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WO/2001/070757A2 |
Thioketals and thioethers are provided that inhibit the expression of VCAM-1, and which can be used in the treatment of VCAM-1 mediated diseases including inflammatory disorders, cardiovascular diseases, occular diseases, autoimmune dise...
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WO/2001/070841A2 |
Mixtures of isomeric alkylthiated mononuclear aromatic amines comprising in the range of 30 to 70 mole percent of (i) at least one 3,5-di(alkyl-thio)-2,6-diamino-1-alkylbenzene and in the range of 30 to 70 mole percent of (ii) at least o...
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WO/2001/070675A2 |
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell pr...
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WO/2001/070671A2 |
This invention provides compounds of Formula (1), their N-oxides and agriculturally suitable salts wherein A, B, J, R?1¿, R?2¿, R?3¿ and R?4¿ and n are as defined in the disclosure. Also disclosed are methods for controlling arthropo...
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WO/2001/070680A1 |
A process whereby 4-bromothioanisole, which is useful in drugs, pesticides, functional materials, etc., can be industrially advantageously produced at a high purity by a convenient procedure. This process is characterized by reacting thi...
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WO/2001/070677A1 |
A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures of formula (I) (where the variables are as defined in the claims). The compounds are inhibitors of $g(g)-secretase, and hence are usef...
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WO/2001/070693A2 |
Compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess metalloprotease activity. In particular, the compounds have a structure according to the following Formula (I): whe...
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WO/2001/070667A1 |
A compound represented by the formula (I) or a salt or solvate thereof; and a composition and a kit both containing any of these. In said formula X represents CH, sulfur, or nitrogen; Y represents CH, sulfur, or nitrogen or is absent; (a...
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WO/2001/068597A1 |
Derivatives of N-deacetyl- thiocolchicine or of the isoster thereof of formula (I), wherein: n is an integer of 0 to 8; Y is a CH¿2? group or, when n is 1, can also be a group of formula NH. Compounds (I) have anti-proliferative activity.
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WO/2001/068582A1 |
The present invention relates to novel fatty acid analogous of the general formula (I): R¿1?- [x¿i? - CH¿2?]¿n? - COOR¿2?, wherein R¿1?, R¿2?, X¿i? and n are defined in the description a salt, prodrug or complex thereof, which ca...
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WO/2001/068605A1 |
The invention relates to polycyclic aryl and heteroaryl substituted benzene compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment...
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WO/2001/068619A1 |
Diarylamines, such as 5-amide substituted diarylamines of formula (I) or formula (II) wherein A is hydroxy, C¿1-6? alkoxy, or NR¿6?OR¿7?; X is OR¿12?, NR¿13?R¿12?, or NR¿14?; inhibitors of MEK and are useful in the treatment of a ...
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WO/2001/068599A2 |
A dosing form for at least one solid reagent for use in conventional organic and inorganic synthesis, in parallel synthesis, and in split and mix synthesis in combinatorial chemistry is provided as compressed tablets each containing the ...
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WO/2001/068596A1 |
The present invention relates to novel thiol stabilised gold nanoparticles for decorative uses. Methods of their preparation, compositions comprising them and uses of gold nanoparticles and compositions are also described.
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WO2000053577A9 |
The design, synthesis and antiviral activity of novel mercaptosalicylhydrazides are disclosed, which inhibit human immunodeficiency virus type-1 integrase (HIV-1 IN), an essential enzyme for effective viral replication. Examples of the c...
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WO/2001/068660A1 |
Glucopyranosyloxybenzylbenzene derivatives of the general formula (I) and salts thereof, which exhibit excellent human SGLT2 inhibiting activity and are useful as preventive or therapeutic drugs for diabetes, obesity and so on; and inter...
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WO/2001/068593A2 |
The present invention relates to a class of amino acid derivatives with HIV aspartyl protease inhibitory properties.
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WO/2001/068595A1 |
The invention aims at providing novel sulfur compounds, molecular compounds containing the same as the component compound, and so on. The above aim is achieved by using sulfur compounds of the general formula (I) wherein Rs are each inde...
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WO/2001/067129A2 |
Method and reagent composition for covalent attachment of target molecules, such as nucleic acids, onto the surface of a substrate. The reagent composition includes epoxide groups capable of covalently binding to the target molecule. Opt...
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WO/2001/064695A1 |
The invention concerns a method for preparing bismuth tris-trifluoromethanesulphonate, characterised in that it consists in reacting CF¿3?SO¿3?H trifluoromethanesulphonic acid with Bi¿2?O¿3? bismuth trioxide in a medium consisting of...
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WO/2001/064630A1 |
The present invention provides an intermediate compound used for synthesis of polyene chain structure, that is an important moiety of carotenoid compounds, a process for preparing the same, and carotenoid polyene chain compounds prepared...
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WO/2001/062714A1 |
There are provided novel compounds of formula (I), wherein R?1¿, R?2¿, X, Y, V, W and Z are as defined in the specification, and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof; together with processes ...
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WO/2001/062708A1 |
Benzoic acid derivatives represented by the general formula (I), nontoxic salts thereof, a process for producing the same and drugs containing the same as the active ingredient; (I) wherein A, B, R?6¿ and R?7¿ represent each a carbon r...
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WO/2001/062721A1 |
There is disclosed the use of a compound of formula (I), wherein R?1¿, R?2¿, X, Y, V, W and Z are as defined in the specification, and pharmaceutically acceptable salts, enantiomers or racemates thereof, in the manufacture of a medicam...
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WO/2001/062668A2 |
This invention is directed to novel and known sulfur containing compounds and pharmaceutically acceptable salts thereof that have utility as antifungals and as antiproliferative agents against mammalian cells, in particular cancer cells ...
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WO/2001/062718A1 |
A compound represented by the general formula (I), a pharmacologically acceptable salt thereof, or a hydrate or solvate thereof. In said formula A is optionally substituted 3-sulfamoylphenyl, optionally substituted 2-thienyl, etc.; R¿10...
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WO/2001/062720A1 |
1-chloro-4-[4-(alkylthio)phenoxy]-benzenes of formula (I) can be obtained when potassium salts, rubidium salts and/or cesium salts, optionally mixed with sodium salts of a 4-alkylthio-phenol of formula (II), are reacted with a 4-chloroha...
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WO/2001/060788A1 |
A process for the production of methionine which comprises (a) a first step of contacting hydroxymethylthiobutyronitrile with ammonia or a solution of ammonia to produce a product comprising 2-amino methylthiobutyronitrile, (b) a second ...
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WO/2001/060783A1 |
Phenacylamine derivatives of the general formula (I) or salts thereof, useful as pest controllers wherein A is alkyl, cycloalkyl, optionally Y- substituted phenyl, optionally Y-substituted pyridyl, or optionally Y-susbtituted pyrazolyl; ...
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WO/2001/060797A1 |
The invention relates to novel phenyl-substituted heterocyclic enaminones of general formula (I) in which A, B, Q¿1?, R?7¿, R?8¿, R?9¿, R?10¿, X, n, q and m have the meanings cited in the description. The invention also relates to s...
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WO/2001/060803A1 |
The invention relates to novel fused imidazolium derivatives useful as drugs, particularly in the treatment of cancers, and novel intermediates for the preparation of the derivatives. Novel imidazolium derivatives fused with aromatic car...
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WO/2001/060791A1 |
A process for preparing 2-hydroxy-4-methylthiobutanoic acid by hydrolyzing 2-hydroxy-4-methylthiobutanenitrile and/or 2-hydroxy-4-methylthiobutanamide in the presence of sulfuric acid to thereby obtain a reaction fluid containing 2-hydro...
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WO/2001/060789A1 |
A process for the production of methionine which comprises: (a) a hydrolysing the methionine amide or the hydroxy analogue of methionine amide in the presence of a catalyst comprising titanium to produce ammonium methioninate, said catal...
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WO/2001/060790A1 |
A process for the production of methionine which comprises (a) hydrolysing the methionine amide in the presence of a catalyst comprising titanium to produce ammonium methioninate, said catalyst having a porosity of from 5 to 1000 nm, a t...
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WO/2001/058854A1 |
Compound (2-hydroxy-2-methyl-N-(4-X-3-(trifluoromethyl)phenyl)-3-(2,2
,2-perfluoroacylamino)propionamide) applied topically, specifically inhibits and/or eliminates cutaneous androgen receptors and thus finds cosmetic use in skin afflict...
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WO/2001/058889A1 |
The present invention provides an antiproliferative compound having the structural formula (I) wherein X is oxygen, nitrogen or sulfur; Y is selected from the group consisting of oxygen, nitrogen and sulfur wherein when Y is oxygen or ni...
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WO/2001/058835A1 |
The present invention relates to a process for the resolution of DL-racemic mixtures of compounds which crystalize in the form of a conglumerate. Both, the D and L-enantiomers are obtained according to the invention in a industrially fea...
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WO/2001/058833A1 |
The invention concerns a method for functionalising a double bond and, more particularly, a double bond bearing a metalloid atom. Said functionalisation is produced by the action of perhalogenated sulphonyl chloride on the carbon bearing...
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WO/2001/058864A1 |
An industrial process for the preparation of 2-hydroxy-4-methylthiobutyric acid esters comprising substantially monomers which process comprises reacting 2-hydroxy-4-methylthiobutyric acid, with an alcohol in the presence of an acid cata...
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WO/2001/056981A1 |
Compounds of the formula (I) wherein X represents hydrogen or hydroxy; Y represents oxygen or sulphur or oxidized sulphur selected from the groups S(O) and S(O¿2?); R?1¿ and R?2¿, which may be the same or different, represent hydrogen...
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