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WO/2002/062751A1 |
Novel cystine derivatives represented by the following general formula (involving free compounds, salts, solvates, etc.) such as N,N'-bis(2-hydroxybenzyl)-L-cystine: (I) Use of these compounds having an excellent effect of inhibiting the...
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WO/2002/060872A1 |
The present invention relates to methods for the synthesis of chemical compounds for screening as potential tubulin polymerization inhibitors. The invention also provides chemical compounds with tubulin polymerization inhibitor activity.
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WO/2002/060859A2 |
The present application describes modulators of MCP-1 of formula (I) or pharmaceutically acceptable salt forms thereof, useful for the prevention of rheumatoid arthritis, multiple sclerosis, atherosclerosis and asthma.
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WO/2002/059074A1 |
A compound represented by the general formula (I) (wherein R?1¿ represents C¿1-6? alkyl, etc.; R?2¿ and R?3¿ are the same or different and each represents hydrogen, etc.; R?a¿ represents C¿1-6? alkyl, etc.; Arom represents aryl, et...
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WO/2002/058690A2 |
The present invention relates to methods for the prophylaxis, management and treatment of certain diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD) by the administration ...
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WO/2002/059077A1 |
It is intended to provide drugs which have cholesteryl ester transfer protein inhibitory effect and are useful as blood lipid lowering agent, etc. Namely, compounds represented by the following general formula (I), salts thereof, and med...
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WO/2002/058698A2 |
The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases m...
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WO/2002/057216A1 |
Compounds represented by the general formula (|), which exhibit excellent immunosuppressive and/or antiallergic effects and are useful as drugs: (|) wherein R?1a¿, R?1b¿, R?1c¿, and R?1d¿ are each independently hydrogen, lower alkyl,...
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WO/2002/056880A1 |
Triphenylmethane derivatives of the formula (I) are disclosed. The compounds are inhibitors of the mitotic kinesin KSP and are useful in the treatment of cellular proliferative diseases, such as cancer, hyperplasias, restenosis, cardiac ...
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WO/2002/053624A1 |
A polymer crosslinked by means of disulphide bonds and which degrades at low redox potential sites in the body (e.g. colon, the ischaemic heart, post-stroke brain, rheumatoid joints, tumours etc.) is used to form a delivery device for se...
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WO/2002/053522A2 |
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant inventive are ligands for estrogen receptors and as such may be useful for t...
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WO/2002/051793A1 |
Compounds according to structural diagram (I) useful for treating neurological disorders wherein: R?1¿ and R?3¿ are selected from benzyl, phenethyl, naphthylmethyl, C¿1-8?alkyl, C¿3-6?cycloalkylC¿1-4?alkyl and CH¿3?SC¿1-4?alkyl; R...
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WO/2002/051983A2 |
The present invention relates to novel selective cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making
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WO/2002/051397A1 |
Cytokine production inhibitors containing as the active ingredient aniline derivatives represented by the general formula (I) or salts thereof: (I) wherein A is CO or SO¿2?; Cy is aryl or a heterocyclic group; R?1¿ and R?2¿ are each i...
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WO/2002/049641A2 |
The invention relates to the use of aminoacetonitrile compounds of formula (I), wherein R1, R2, R3, R4, R8, R9, A, m and n have the significances given in claim 1, in the control of endoparasites, especially helminths, in warm-blooded pr...
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WO/2002/049967A2 |
Novel sulfur-containing ligands for binding of heavy metals are disclosed. The ligands incorporate a central ring structure and pendant alkyl-thiol chains. The ligands are of the general structure (I) or (II) where n is an integer from 1...
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WO/2002/050021A1 |
A compound of formula (I): namely (2S)-2-amino-4-{[2-(ethanimidoylamino)ethyl]thio}butanoic acid, compound with prosphoric acid, or a solvate or physiologically functional derivative thereof, is useful as a relatively non-hygroscopic sel...
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WO/2002/048073A1 |
The invention relates to a method for producing compounds having at least one -CF¿2?-O bridge per molecule, according to which: a) an acid is added to at least one ketene dithioketal; b) the obtained bis(alkylthio)carbenium salt is reac...
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WO/2002/048250A2 |
Aromatic and aliphatic organic thiol compounds are disclosed which can be utilized to plasticize and/or stabilize halogen-containing polymer compositions, especially poly(vinyl chloride) compositions. Compounds of the present invention a...
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WO/2002/048099A1 |
The invention relates to compounds of formula (I), wherein the variables have the following meanings: D means a phenyl or a pyridyl which is unsubstituted or is mono- or polysubstituted by Hal, A, OR?2¿, N(R?2¿)¿2?, NO¿2?, CN, COOR2 ...
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WO/2002/046141A2 |
The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for...
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WO/2002/046172A2 |
The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for...
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WO/2002/046129A2 |
Compounds having the formula or therapeutically acceptable salts thereof, are histone deacetylase (HDAC) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are d...
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WO/2002/046181A2 |
The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for...
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WO/2002/046149A2 |
The invention comprises a process for preparing a compound having the formula where Z and W are the same or different, and selected from the group consisting of O, NH and NR, where R is H, alkyl, cycloalkyl or aryl, R' is alkyl, cycloalk...
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WO/2002/044150A1 |
Process for the preparation of a compound of the general formula (I) and pharmaceutically acceptable salts and solvates thereof, (I) characterised by reacting an N-(amino-tioxo-methyl)-1H-indole-2-carboxamide of the general formula (II),...
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WO/2002/044140A1 |
The present invention provides allylic disulfone of Chemical Formula 1, an important intermediate which can be used for syntheses of retinoids and carotenoids, a process for preparing the same, and a process for preparing retinoid compou...
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WO/2002/043648A2 |
This invention relates to novel compounds of formula I that are liver selective glucocorticoid receptor antagonists, methods of preparing the compounds and methods for the use of the compounds in the regulation of metabolism and lowering...
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WO/2002/042414A2 |
This invention is directed to compounds (see Figure 1) that provide for sustained systemic concentrations of GABA analogs following administration to animals. This invention is also directed to pharmaceutical compositions including and m...
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WO/2002/042258A1 |
N-protected-L-homocysteine disulfide of the formula (I) or an activated form thereof is reacted with (S)-2-amino-6,6-dimethoxyhexanoic acid, methyl ester to give the disulfide intermediate of the formula (II). The disulfide intermediate ...
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WO/2002/042261A2 |
The present invention relates to a biphasic process for preparing a compound of formula (I) from a compound a compound of formula (II) and (III).
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WO/2002/042248A2 |
The present invention relates to naphthalene derivatives of formula (I), wherein X is S, S(O), S(O)¿2?, S(O)¿2?NH, P(O)OCH¿3?, P(O)OH, NH, N(CH¿3?), NHC(O)NH, C(O), C(O)O, NHC(O), CH(OH), CH=N, CH=CH, CH¿2?NH, C(=NH); R?1¿ is aryl ...
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WO/2002/042262A2 |
A composition comprising 2-alkylthio- or 2-aryl(heteroyl)thio-substituted p-phenylenediamine of formula (I), where X and Y are the same or different and selected from the group NH¿2? or NHR (whwere R is alkyl, cycloakyl or aryl); and R'...
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WO/2002/040446A1 |
A novel class of compounds of the general formula (I): wherein Z is arylene or a divalent radical derived from a 5 or 6 membered heteroaromatic ring E is which act to antagonize the action of the glucagon hormone on the glucagon receptor...
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WO/2002/040602A1 |
The present invention relates to a process for the preparation of scratch-resistant coatings by dual cure of compositions comprising surface active benzoyl compounds wherein at least one non-polar fluorinated alkyl group is present. The ...
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WO/2002/040444A1 |
Novel compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any di...
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WO/2002/038850A2 |
This invention provides a method of treating fibrous substrates, such as leather, by contacting the substrate with a fluorochemical compound comprising: a fluorochemical oligomeric portion comprising an aliphatic backbone with a pluralit...
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WO/2002/038539A2 |
A method of making calcium-2-hydroxy-4-(mercaptomethyl)butanoate includes combining and mixing 2-hydroxy-4-(mercaptomethyl)butanoic acid and a calcium salt selected from calcium oxide and calcium hydroxide and water in a first reaction z...
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WO/2002/038530A1 |
A carboxylic acid type lipid which is a negatively charged lipid capable of stably donating negative charges to the surface of endoplasmic reticula without producing any side effect. It is represented by the following general formula [1]...
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WO/2002/036555A1 |
Novel sulfamides of formula (I) are disclosed. The compounds exert an inhibitory action on the processing of APP by gamma-secretase, and are therefore useful in the treatment or prevention of Alzheimer's disease.
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WO/2002/036544A1 |
A method of resolving optical isomers which comprises mixing in an aqueous solution an amino acid derivative in the form of a mixture of D- and L-isomers (for example, N-(tert-butoxycarbonyl)-DL-alanine) with a hydrophilic compound isome...
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WO/2002/036547A1 |
NF-Kappa B activation inhibitors, inflammatory cytokine production inhibitors, matrix metalloprotease production inhibitors, inflammatory cell adhesion factor expression inhibitors, anti-inflammatory agents, antirheumatic agents, immunos...
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WO/2002/036550A1 |
Compounds represented by the following general formula [I]: wherein A, R, X, Y and n are each as defined in the description; salts thereof, and insecticides/miticides characterized by containing one or more members selected from the abov...
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WO/2002/036554A2 |
Novel amidino-urea 5-HT¿7? receptor ligands, methods of preparing such ligands, intermediate compounds useful in the preparation of the receptor ligands, pharmaceutical compositions comprising the receptor ligands, and methods of treati...
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WO/2002/032226A1 |
Ectoparasitic insect pest controllers for animals, containing hydrazine derivatives of the general formula (I) as the active ingredient, and methods for application of the same: (I) [wherein A is (II) (III) (IV) (V) (wherein R?4¿ and R?...
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WO/2002/032376A2 |
This invention is directed to compounds that provide for sustained systemic concentrations of therapeutic or prophylactic agents following administration to animals. This invention is also directed to pharmaceutical compositions includin...
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WO/2002/033596A2 |
The invention provides a method of operating a computer system, and a corresponding computer system, for performing a discrete substructural analysis. First, a database of molecular structures is accessed. The database is searchable by m...
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WO/2002/030883A1 |
A process for the preparation of thiophenols of formula (I) wherein n is an integer from 1 to 5 and R is hydrogen, alkyl, hydroxyalkyl, alkylamino, dialkylamino, alkenyl, alkynyl, alkoxy, alkylthio, phenyl, naphthyl, phenoxy, phenylthio,...
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WO/2002/030884A2 |
The present invention relates to novel sulfide and disulfide compounds, compositions comprising sulfide and disulfide compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and ...
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WO/2002/030880A2 |
The invention relates to compounds of formula (I) wherein the substituents R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, X, Y, U, V and W have the designation cited in patent claim 1. The compounds are suitable for producing pharmaceuticals for fig...
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