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WO/2004/032975A2 |
This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compound...
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WO/2004/033397A2 |
The present invention provides compositions and methods for assessing profiles of catalytically active enzymes in compositions containing a plurality of proteins. In preferred embodiments, the enzyme is a hydrolase, most preferably a cys...
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WO/2004/033419A1 |
Compounds having methionine aminopeptidase-2 inhibitory (MetAP2) are described. Also described are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and me...
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WO/2004/031287A1 |
Compounds of the formula (I) wherein R1 is C1-C18alkyl, C5-C12-cycloalkyl, phenyl, benzyl, or allyl; n is 1 or 2; if n is 1, R2 is C4-C18alkyl, C5-C12cycloalkyl, aryl or heteroaryl, benzyl, allyl, (CH2),mCOOR3, or is (CH2)mCN; if n is ...
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WO2002032856A9 |
Compounds of Formula I and Formula II, and their N-oxides and agriculturally suitable salts, are disclosed that are useful for controlling invertebrate pests, Formula (I), Formula (II) wherein A, B, J, R1, R2, R3, R4, and n are as define...
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WO/2004/029018A1 |
A compound represented by the following formula (1): (1) wherein R represents a residue having either a reactive group or a group capable of changing into a reactive group; n is an integer of 3 or larger; X represents a residue capable o...
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WO/2004/026817A1 |
An amino alcohol derivative represented by the general formula (1): (1) &lcub e.g., (±)-2-amino-5-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]-2-
methylpentan-1-ol&rcub . It has excellent immunosuppressive activity and is reduced in side ...
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WO/2004/026815A2 |
The present invention is related to a compound of the formula (I), (II), (III), (IV), (V): wherein Z1, Z2, Z3 and Z4 are each and independently selected from the group comprising C(O)-, -C(S)-, -C(O)-NR10-, -C(S)-NR11-, -C(N-CN)-NR12-, -...
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WO/2004/024680A1 |
The invention disclosed certain alkyl-S-alkyl hydrazone compounds of formula (I) with insecticide, fungicide, herbicide activities, formula (I) wherein Q is a group of formulae (a), (b), (c) and (d) and their preparation. The invention a...
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WO/2004/024678A1 |
The invention disclosed certain unsaturated sulfur containing-oxime ether compounds of formula (I) with fungicidal activity, formula (I) wherein A= H, halo, CN, alkyl, alkoxy, haloalkyl, haloalkoxy; X=CH or N; Y is O, S, NR6; R1, R6 =H o...
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WO/2004/024139A1 |
A melanin extinguisher which contains either a metal chelate compound represented by the following formula (I): (I) (wherein M represents a metal and R represents OH, O-(lower alkyl), an N-bonded amine, an N-bonded amino acid, or an N-bo...
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WO/2004/022775A1 |
A method for identifying antibacterial agents comprises depleting bacteria of a strain comprising a luxAB construct of Ca2+, incubating the Ca2+ depleted bacteria with an agent the antibacterial effect of which shall be determined, recor...
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WO/2004/022766A1 |
A process for easily producing an L-&agr -methylcysteine derivative or its salt, which is useful as a drug intermediate, from a cheap easily procurable raw material through an enzymatic D-stereoselective hydrolysis of racemic 5-halomethy...
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WO/2004/022526A1 |
This invention relates to class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resor...
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WO/2004/022523A2 |
The present invention relates to compounds of formula (AA), (I) and (X), useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment ...
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WO/2004/022533A1 |
Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present ...
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WO2004000789A9 |
The present invention is directed to compounds, compositions, and use of compounds the structural Formula (I).
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WO/2004/018416A1 |
The present invention relates to 4-[(alkylsulfanyl)methyl]-1, 2-benzenediol derivative, preparation method thereof and antioxidant containing the same. More particularly, 4-[(alkylsulfanyl)methyl]-1, 2-benzenediol derivative following Fo...
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WO/2004/018415A1 |
Sulfonamide derivatives represented by the general formula (1) or salts thereof; insecticides for agricultural and horticultural use containing the same as the active ingredient; and usage thereof: (1) [wherein A is optionally substitute...
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WO/2004/018410A1 |
A novel agricultural chemical, especially an insecticide or acaricide; and a substituted benzanilide compound represented by the general formula (1): (1) G-7 G-13 G-71 [wherein G represents a ring represented by G-7, G-13, G-71, etc.; W1...
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WO/2004/018414A2 |
The present invention relates to compounds of formula I or a pharmaceutically acceptable salt thereof, wherein X=NH Y=CO, CS, -C(=N-CN) or X and Y together form an alkene, or C3-C5 cycloalkyl; R1 is -COOH; R2 is an electron withdrawing g...
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WO/2004/016583A1 |
The compounds of formula (I) are substituted glycine derivatives useful in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, arthritis, neuropatho...
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WO2003006425A9 |
The present invention relates to compounds of the general formula (I); or salts thereof, as anti-inflammatory, immunomodulatory and anti-proliferatory agents.
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WO/2004/016584A1 |
A fluorinated urethane compound represented by the general formula I[-NHC(=O)O-X1-Rf1-R1]m[-NHC(=O)O-(X2(-CH2Cl)O)p-R2]n (1) [wherein I is a group formed by removing an isocyanate group from a polyisocyanate compound; X1 is a divalent or...
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WO/2004/016221A2 |
Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides sulfonami...
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WO/2004/016569A1 |
The present application relates to a new process for the reduction of sulfoxides to sulfides, wherein said process provides the production of a sulfide compound of formula (I), by the reduction of a sulfoxide compound of formula (II): wi...
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WO/2004/014844A2 |
This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as antagonists,...
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WO/2004/014825A1 |
The invention relates to compounds of the formula, a prodrug thereof, or a pharmaceutically acceptable salt, solvate or stereoisomer of the compound or of said prodrug; which exhibit anti-inflammatory and immunodulatory activity. Also di...
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WO/2004/014847A1 |
The present invention relates to sulfones that are useful in the treatment of chemokine-mediated disorders. In certain embodiments, the present invention concerns the compounds that are MCP-1 receptor antagonists.
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WO/2004/014682A1 |
A vehicle door has a supporting frame (10) substantially in the form of a rectangular annular hat beam (13-16) of high-strength steel, which, with its outer side flange (17), carries the outer panel (28) of the door and has its crown (12...
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WO/2004/012726A2 |
Therapeutic methods for the prevention ad treatment of conditions and diseases of the gastrointestinal tract involving an overproduction of nitric oxide by inducible nitric oxide synthase are described, the methods including administerin...
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WO/2004/013094A2 |
One aspect of the present invention relates to copper-catalyzed carbon-heteroatom and carbon-carbon bond-forming methods. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-sulfur bond b...
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WO/2004/013085A1 |
Compounds having the formula are useful for treating conditions which arise from or are exacerbated by angiogenesis. Also disclosed are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, metho...
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WO/2004/013077A2 |
A compound of formula (I) or (II): wherein A is hydrogen or CR1R2; Y and Z are each, independently, hydrogen or a halogen; X is -NR4R5, or R7; R1 is hydrogen, or a substituted or unsubstituted alkyl or alkenyl group containing 1-4 carbon...
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WO/2004/011410A1 |
Compounds of formula (I):wherein variable groups are as defined within; for use in the inhibition of 11$g(b)HSD1 are described.
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WO/2004/011417A1 |
The invention relates to N-bisaryl- and N-aryl-cycloalkylidenyl-a-hydroxy- and a-alkoxy acetic acid amides of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein R1 is hydrogen, C1-C12alkyl...
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WO/2004/009533A1 |
Novel acetylamino benzoic acid compounds, methods of using and pharmaceutical compositions comprising an acetylamino benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by mo...
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WO/2004/009066A1 |
The present invention relates to nitric oxide/releasing amidine diazeniumdiolates, compositions comprising same, methods of using same, and a method for preparing same from imidate diayeniumdiolates and primary or secondary amines.
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WO/2004/007427A1 |
The present invention relates to a compound of formula (I) or (II), processes for preparing them, peptides including them and kits involving them.
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WO/2004/007439A1 |
A compound represented by the following general formula or its salt has an agonistic activity to peroxisome proliferator activated receptor &dgr (PPAR&dgr ) and, therefore, is useful as an agent elevating blood high density lipoprotein (...
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WO/2004/007423A1 |
Organic amine salts of compounds of formula (I), and their pharmaceutically acceptable salts, and uses in medical therapy are provided.
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WO/2004/007440A1 |
The invention relates to compounds of formula: (I) or a salt or solvate thereof, wherein: R1 is -11CH2R5 or [18F]-C1-4 fluoroalkyl wherein R5 is hydrogen or C1-4 alkyl; R2 is hydrogen or C1-4 alkyl; R3 is halo; and R4 is halo, C1-4 alkyl...
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WO2003074990A9 |
The present invention relates to artificial receptors and arrays or microarrays of artificial receptors or candidate artificial receptors. Each member of the array includes a plurality of building block compounds, typically immobilized i...
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WO/2004/007441A2 |
The invention relates to the bis-hydrochloride of 4,4'-dithiobis-(3-aminobutane-1- sodium sulphonate) and the bis-trifluoroacetate of 4,4'-dithiobis-(3-aminobutane-1-sulphonate of 2,2-dimethylpropyl). The invention also relates to a phar...
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WO/2004/007407A2 |
The present invention includes methods and compositions for increasing the fluorous nature of an organic compound by reacting it with at least one fluorous compound to produce a fluorous tagged organic compound. The increased fluorous na...
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WO/2004/007492A1 |
The present invention relates to new Macrocycles of Formula (I), and their use for the treatment of cancer.
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WO/2004/005513A2 |
This invention relates to the inhibition of histone deacetylase (HDAC) expression and enzymatic activity. The invention provides methods and reagents for inhibiting HDAC-7 and HDAC-8 by inhibiting expression at the nucleic acid level or ...
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WO/2004/005233A1 |
The invention concerns novel substituted 1,3-diphenylprop-2-en-1-one derivatives, pharmaceutical compositions comprising same, their therapeutic uses, in particular for treating cerebral ischemia. The invention also concerns a method for...
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WO/2004/004648A2 |
The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound ...
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WO/2004/005245A1 |
A process for the preparation of compound (III) which comprises the reaction between a compound of general formula (V) and dicyano acetylene (IV), said reaction carried out in the presence of water (IV), (V), (III) wherein R is selected ...
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