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WO/2005/092836A1 |
A compound of the formula (I) wherein the variables X1, X2, B, D, R1 to R7.including R3', p, y, q, and z, are as defined or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mixtures thereof, useful for t...
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WO/2005/092317A1 |
The invention provides compounds of formula (I) or a pharmaceutically acceptable ester, amide, solvate or salt thereof, including a salt of such an ester or amide, and a solvate of such an ester, amide or salt. The invention also provide...
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WO/2005/092840A1 |
The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invent...
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WO/2005/092835A1 |
The present invention relates to inhibitors of serotonin and/or norepinephrine reuptake and specifically provides compounds of formula (I): wherein A is selected from -O- and -S-; X is selected from C1-C8 alkyl, C2-C8 alkenyl, and C4-C8 ...
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WO/2005/092997A1 |
Disclosed is a surface treating agent containing a fluorine-containing polymer having: (A) a repeating unit derived from a fluorine-containing compound which is represented by the following formula: CH2=C(-X)-C(=O)-Y-[-(CH2)m-Z-]p-(CH2)n...
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WO/2005/092845A1 |
The present invention is directed at substituted heteroaryl- and phenylsulfamoyl compounds, pharmaceutical compositions containing such compounds and the use of such compounds as peroxisome proliferator activator receptor (PPAR) agonists...
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WO/2005/090343A1 |
A process for stereoselective synthesis of a compound of Formula (I) wherein R1, R2, R3, R4, and R5 are as described herein.
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WO/2005/089269A2 |
Substituted phenol derivatives of Formula (I) are useful as antiproliferative agents including, for example, anticancer agents, and as radioprotective and chemoprotective agents.
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WO/2005/087717A1 |
1,5-Dithiaocta-2,7-diene-5-oxide-1-yl(DODOyl) compounds and derivatives thereof, referred to collectively as DODOyl-derived compounds (DDCs), and chiral enantiomers and derivatives thereof, are described, which are integrin modulators th...
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WO/2005/087710A1 |
A compound represented by the formula (1) (wherein the symbols are the same as defined in the description), a salt thereof, and a prodrug thereof. They unexpectedly have excellent GPR40 receptor agonistic activity and are excellent in pr...
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WO/2005/087700A2 |
The present invention discloses bisphenyl compounds of the formula (1): wherein R1, R2, R3, R4, R5, R6, X, Y, W are defined herein after. These compounds are useful as pharmaceuticals.
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WO/2005/087215A1 |
The invention relates to acetyl 2-hydroxy-1,3-diaminospirocyclohexanes and derivatives thereof that are useful in treating at least one disease, disorder, and condition associated with amyloidosis. Amyloidosis refers to a collection of d...
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WO/2005/085216A1 |
An isoxazoline-substituted benzamide compound of the general formula: (1) [wherein each of A1, A2 and A3 independently represents a carbon atom or nitrogen atom; G a benzene ring, etc.; W an oxygen atom or sulfur atom; X a halogen atom, ...
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WO/2005/083131A1 |
The invention provides novel extractants for palladium which bring about enhancement in the extraction speed as compared with the extraction with DHS (which is one of the current extractants) and a process for the separation and recovery...
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WO/2005/080309A1 |
There is provided a stereoselective route to a compound of formula (1): wherein R represents H or an alkali metal, Ar1 represents 4-chlorophenyl and Ar2 represents 2,5-difluorophenyl.
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WO/2005/080325A2 |
Thiol ester compositions, methods of making the thiol ester compositions, and methods of using the thiol ester compositions are provided. In some embodiments, the thiol ester compositions include thiol esters, hydroxy thiol esters and cr...
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WO/2005/080319A1 |
The invention relates to hydrazino alcohol derivatives of Formula (I) wherein ; R1 is hydrogen, lower alkyl or an optionally substituted phenyl or heteroaryl group; R2 is hydrogen or lower alkyl, or R1 and R2 may form together with the n...
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WO/2005/080324A1 |
The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invent...
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WO/2005/079398A2 |
A compound having the formula Y - A - Z, wherein: A is a 5, 6, or 7 member ring that is monocyclic or is fused to 1 to 3 additional 4 to 8 member rings; wherein ring A and, independently, the fused additional rings are carbocyclic or het...
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WO/2005/080340A1 |
Compounds having a formula (1) or a pharmaceutically acceptable salt or prodrug thereof, are provided, and are useful for the treatment of metabolic disorders.
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WO/2005/077895A1 |
The invention provides cytokine production inhibitors useful as preventive or therapeutic agents for diseases accompanied with abnormally enhanced immune function. Cytokine production inhibitors containing as the active ingredient thioam...
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WO/2005/077122A2 |
The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of liver X receptors (LXRs).
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WO/2005/075426A1 |
The present invention relates to novel dipeptidyl peptidase IV (DPP-IV) inhibitors or general formula (1) useful for treating diabetes, non-insulin dependent diabetes mellitus, impaired glucose tolerance, inflammatory bowel disease, ulce...
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WO/2005/075418A2 |
Disclosed is a series of N-deacetylthiocolchicine derivatives of formula (I) in which: - the linker is a bivalent straight or branched C1-C8 alkyl residue, C3-C8 cycloalkyl, a phenylene or heterocyclic C4-C6 ring; - the G1 and G2 junctio...
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WO/2005/075410A1 |
Compounds of formula (I), for clinical treatment of autoimmune diseases, inflammatory diseases, organ transplant rejection and malignant neoplasia. A pharmaceutical composition comprising a compound of formula (I) in an amount giving a d...
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WO/2005/073164A1 |
The present invention relates generally to compounds comprising a hydrocarbon chain portion and more particular to compounds comprising chemical derivatizations of the hydrocarbon chain which are useful therapeutic and prophylactic molec...
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WO/2005/073183A1 |
It is intended to provide a compound which has an effect of inhibiting the adhesion of LFA-1 to its ligand ICAM-1 and is useful in preventing or treating inflammatory diseases and autoimmune diseases, in particular, rheumatoid arthritis,...
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WO/2005/073165A1 |
The invention aims at providing highly effective insecticides. Compounds represented by the general formula (1); insecticides containing the same as the active ingredient; and a process for the production thereof: (1) wherein A1, A2, A3 ...
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WO/2005/073184A1 |
The invention relates to substituted 1,3-diphenylprop-2-en-1-one derivative compounds, pharmaceutical and/or cosmetic compositions containing same, and the applications thereof in therapeutics and cosmetics. The invention also relates to...
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WO/2005/073158A1 |
The invention relates to compounds having general formula (I), wherein R1 and R2 represent, independently of each other, -OH, or -CH2-O-R3, or -CH2-S-R3, or formula (II), R3, R4, R5 and R6 representing, independently of each other, -H or...
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WO/2005/073182A1 |
A method for producing a fluorine-containing unsaturated sulfonyl fluoride represented by the chemical formula: RfSO2F (wherein Rf is as defined below) is characterized in that a fluorine-containing unsaturated sulfonyl chloride represen...
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WO/2005/073185A1 |
Novel C3-C19 alkyl- and aryl-thiotrifluoroacetates are provided which have the structure [Formula (I)], wherein Q is C9-C19 alkyl or aryl, and are useful protecting agents for the amino or hydroxy functional groups of amines, amino acids...
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WO2005040105B1 |
The invention relates to novel surfactant compounds and the use thereof for preparing metastable supramolecular systems or nanoparticles. Said nanoparticles may be used as vectors for active ingredients, in particular therapeutic active ...
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WO/2005/068411A1 |
A process for the preparation of 6-fluoro-2-methyl-l-indanone which relates to a process of preferential cyclization of (3-fluorophenyl)-isopropenyl-ketone to obtain 6-fluoro-2-methyl 1-indanone regioisomer with respect to 4-fluoro-2-m...
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WO/2005/068415A1 |
Disclosed is a phenylalanine derivative having excellent VLA-4 inhibitory activity which is represented by the following general formula (1) or a salt thereof. (1) (In the formula, R1 represents an aromatic hydrocarbon group having 6-10 ...
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WO/2005/068418A1 |
The invention encompasses novel sulfide and disulfide compounds, compositions comprising sulfide and disulfide compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose...
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WO/2005/063729A1 |
The present invention provides a novel compound represented by the formula (I) wherein each symbol is as defined in the specification, a salt thereof and a prodrug thereof having a superior GPR40 receptor function modulating action, whic...
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WO/2005/063780A1 |
Process for the preparation of substituted pyridine derivatives of formula (I) comprising reaction of a &agr -β-unsaturated carbonyl compound of formula (II) R3-C(O)-C(R1)=C(R2)-G with a Wittig reagent or Horner-Wadsworth-Emmons reagent...
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WO/2005/063689A1 |
A compound which has high angiogenesis inhibitory activity and is useful in therapeutic and preventive drugs which are effective in diseases accompanied by diseased angiogenesis, e.g., cancers and the metastasis of cancers; a process for...
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WO/2005/063018A1 |
Present invention relates to a haloalkene compound of the formula (I)or its salt: wherein each of X1 and X2 is halogen; Y is alkyl, haloalkyl or phenyl; n is 0 to 5; L is -C(=B)Q, -C(=B)B’Q, -C(=B)N(D)Q, -N(D)Q, -N(D)C(=B)Q, -N(D)C(=B)...
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WO/2005/061448A1 |
The present invention provides methods for treating vascular diseases such an aneurysm (particularly abdominal aortic aneurysm) and neointimal hyperplasia. The methods include use of known compounds such as amiloride and oxamflatin, and ...
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WO/2005/061433A2 |
The present invention relates to a compound formula (I): wherein (II) is (III) or (IV), X is bond, -CH2-, -O- or -NH-, R1 and R12 are each independently hydrogen, halogen, lower alkyl, etc., R2 is hydrogen or optionally substituted lower...
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WO/2005/061443A2 |
The invention relates to benzoyl-substituted phenylalanine amides of formula (I), wherein the variables R1 to R15 have the meanings indicated in the description, the agriculturally useful salts thereof, methods and intermediate products ...
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WO/2005/060692A2 |
Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
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WO/2005/061469A1 |
The invention relates to a method for producing chiral mercapto amino acids of formula (I) wherein R1, R2 and R3 can represent hydrogen, C6-C12 aryl, C1-C6-alkyl-C6-C12-aryl, C6-C12-aryl-C1-C6-alkyl, C1-C18-alkyl or C2-C18-alkenyl, R2 an...
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WO/2005/058809A1 |
The invention relates to a method for the separation of methyl mercaptan from reaction gas mixtures obtained by means of the catalytic conversion of H2S with methanol, by means of converting the methyl mercaptan into MMP in the presence ...
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WO/2005/059155A2 |
The invention relates to a method for the fermentative production of methionine, to a method for the insolation of the methionine thus formed, organic substances containing methionine occurring during insulation, to the use thereof in th...
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WO/2005/058810A1 |
A subject matter of the present invention is novel intermediates for the synthesis of (R)-tamsulosin and of its pharmaceutically acceptable salts, and also the associated preparation process.
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WO/2005/058005A2 |
This invention relates to a process for producing a substantially pure disulfide compound of Formula (II) R5-S-S-R2 as disclosed herein, such as disodium 2,2'-dithiobis ethane sulfonate, by an efficient procedure from available, relative...
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WO/2005/056516A1 |
The present invention relates to novel compounds corresponding to the general formula (I) below: to compositions containing them and to their use in pharmaceutical compositions intended for use in human or veterinary medicine, or alterna...
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