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WO/2007/025442A1 |
A method for preparing optically active 4-phenylthio-2-butanol compounds is disclosed. The desired compounds are obtained by reacting propylene epoxides with methallic reagents of formula R1-Ph-A-CH(R2)M, wherein A is S, SO or SO2. The p...
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WO/2007/025763A2 |
The invention relates to compounds, which are suitable for coupling to pharmaceuticals, in particular biopharmaceuticals, in addition to conjugates from the compounds comprising biomolecules or pharmaceutically active substances. The inv...
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WO/2007/023906A1 |
A process for producing an optically active 2-hydroxybutyric ester (1), characterized by reacting an optically active 2,3-epoxybutyric ester (2) with a thiol compound in the presence of scandium trifluoromethanesulfonate or ytterbium tri...
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WO/2007/022900A1 |
The present invention relates to a novel process for the preparation of compounds of the formula (I) by mixing in a first step amino alcohols of the formula (II) with sulfuric acid to yield the salt, by then reacting them in a second ste...
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WO/2007/022901A1 |
The present invention relates to a novel process for the preparation of compounds of the formula (I) by reacting in a first step amino alcohols of the formula (II) with chlorosulfonic acid to give sulfuric acid esters of the general form...
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WO/2007/020381A2 |
A process for the preparation of a compound of formula (I) wherein: R is an alkynyl group; R1 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, phenyl and phenylalkyl, it being possible in turn for all of the receding groups to c...
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WO/2007/017088A1 |
The invention relates to compounds of the general formula (I), wherein R1, R2, R3, R4, R5, R6, R7, Ar1 X, Y, a and b are as defined in claim 1 , and, if appropriate, enantiomers thereof. The active compounds have advantageous pesticidal ...
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WO/2007/017093A1 |
The present invention relates to novel substituted 2-benzyloxy-benzoic acid amide derivatives, processes for their preparation, and their use in medicaments, especially for the prophylaxis and treatment of diseases associated with Cold M...
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WO/2007/014409A1 |
The present invention relates to compounds selected from the group consisting of 14-0- [((Mono- or dialkylamino)-cycloalkylsulfanyl- or -cycloalkyl-oxy)-acetyl, -thioacetyl or - imino-oxy]-mutilins, 14-O-[((Cycloalkyl- or heterocyclylami...
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WO/2007/009772A1 |
The present invention relates to 3-demethoxy-3-aminothiocolchicine glycosyl derivatives of general formula (I) in which R is hydrogen, methyl or hydroxymethyl. The compounds of formula (I) have myorelaxant and anti-inflammatory activity.
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WO/2007/010653A1 |
A salt molten at room temperature that does not contain any organic solvent, excelling in stability; and a display device that is improved in the durability in high-temperature environment by virtue of the use thereof. There is provided ...
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WO/2007/008994A2 |
The present invention relates to compounds of the formula (I), which are modulators of metalloproteinase activity. and pharmaceutically acceptable salts thereof, wherein W is -C(O)-, -OC(O)-, -NHC(O)-, -C(O)O-, Or -C(O)NH-; R1 is phenyl,...
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WO/2007/003581A1 |
The present invention describes phenoxy-acetic acids and pharmaceutical compositions containing the same and methods of using the same. The phenoxy-acetic acids are activators of PPAR-δ and should be useful for treating conditions media...
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WO/2007/000004A1 |
The present invention relates to Compounds of general formula (I), wherein R is hydrogen and R1 is hydroxy or acyloxy, or R is acyl and R1 is hydroxy or acyloxy, X is sulphur, oxygen or NR10, wherein R10 is hydrogen or (C1-4)alkyl; Y is ...
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WO/2007/000001A2 |
A pleuromutilin in the form of a salt with salicylic acid, azelaic acid, sebacic acid or 2- [(2, 6- dichlorophenyl) amino] benzeneacetic acid and their use in the treatment of acne .
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WO/2006/138660A2 |
The invention relates to substituted adamantane compounds of formula (I), pharmaceutical compositions thereof, processes for their preparation, and methods for inhibiting sphingosine kinase and for treating or preventing hyperproliferati...
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WO/2006/137395A1 |
Disclosed are a compound represented by the general formula (1) below which exhibits a high insecticidal effect, and a pesticide containing such a compound as an active ingredient. (1) (In the formula, A1, A2, A3 and A4 respectively repr...
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WO/2006/136846A1 |
The invention provides a compound of formula (I); or a salt or solvate thereof, wherein: R1 is hydrogen or C1-4alkyl; R2 and R4 are each independently selected from C1-4 alkyl, [11C] C1 4alkyl, and [18F]-C1-4 fluoroalkyl provided that at...
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WO/2006/133823A1 |
Benzanilides of the formula: (I) in which X represents hydrogen, halogen, nitro, C1-6 alkylthio, C1-6 alkylsulfinyl, C1-6 alkylsulfonyl or C1-6 alkylsulfonyloxy; Y represents halogen or C1-6 alkyl; R1 represents C1-6 alkyl, C1-6 alkylthi...
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WO/2006/135648A2 |
Methods for treating an animal for endo and/or ecto parasite infestation and/or for protecting an animal from endo and/or ecto parasite infestation using N-phenyl-1,1,1-trifluoromethanesulfonamide compounds are provided, together with me...
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WO/2006/134379A1 |
The present invention provides a method of forming an ion of formula (I) comprising the steps of: (i) reacting a compound of the formula (IIa); with a biopolymer, BP, having at least one group capable of reacting with M to form a covalen...
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WO/2006/133339A2 |
Monoamine re-uptake inhibitors and more specifically serotonin and noradrenaline re-uptake inhibitors are disclosed that have utility in the treatment of disorders of the central or peripheral nervous system in both men and women. The co...
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WO/2006/131465A1 |
The present invention pertains to a reversibly thermochromic system comprising a substituted or an unsubstituted 6,11-dihydroxy-naphthacene-5,12-dione and a base and to a reversibly thermochromic composition comprising the reversibly the...
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WO2006097817A9 |
This invention provides a compound of the formula (I) or a pharmaceutically acceptable salt or solvate thereof. These compounds are useful for the treatment of disease conditions caused by overactivation of VR1 receptor such of pain, or ...
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WO/2006/125593A1 |
A compound of formula (I); in free or pharmaceutically acceptable salt form, where R1, R2, R3, R4, R5, m, n, w, X, Y and Q have the meanings as indicated in the specification, are useful for treating conditions mediated by the CRTh2 rece...
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WO/2006/122652A2 |
The present invention relates to compounds of the Formula (I), wherein X1 and X2 independently represent O, NH or S; R1 and R2 are independently selected from the group consisting of a C1-C30 hydrocarbyl group, an armino acid bonded via ...
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WO/2006/123020A1 |
The invention relates to (hetero)arylsulfonylamino based peptidomimetics of formula (I), wherein A, D, E, J, Q1 R1 , R2, R3, p and j are defined as disclosed, or a pharmaceutically acceptable salt or ester thereof. Compounds of formula (...
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WO/2006/120625A1 |
The present invention concerns the use of a 3-mercaptoheptyl carboxylate, in the form of any one of its stereoisomers or mixture thereof, as flavoring ingredient, in particular to impart fruity, teas and citrus aftertaste. Said compounds...
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WO/2006/121095A1 |
A pharmaceutical composition comprising a compound having the general formula (I) or a pharmacologically acceptable salt thereof as the active ingredient: (I) wherein R1 represents a C6-C10 aryl group which may be substituted by a residu...
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WO/2006/120178A1 |
The present invention relates to compounds of formula I, in which at least one of R5, R6 and R7 is SR12, S(O)R12 or S(O)2R12 group where R12 is a C1-6haloalkyl group, that act, as chemical uncouplers. Compounds of the invention are usefu...
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WO/2006/117995A1 |
A therapeutic agent for loss of scalp hair comprising a lipoic acid or a lipoic acid derivative represented by the formula (1) or a pharmaceutically acceptable salt thereof as an active ingredient: (1) wherein R represents an OH group, a...
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WO/2006/118543A1 |
The invention relates to a water soluble nanocrystal with a nanocrystal core comprising at least one metal M1 selected form an element of main group II, VIIA, subgroup VIIA, subgroup IB, subgroup IIB, main group III or main group IV of t...
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WO2006093823A9 |
This invention provides aryl and heteroaryl compounds of formula (X). The compounds of the invention may be useful as antagonists, or partial antagonist of factor IX and/or factor Xl and thus, may be used to inhibit the intrinsic pathway...
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WO/2006/116038A2 |
Provided are methods for the separation of mono-substituted probucol derivatives from a mixture of both mono- and di-substituted probucol derivatives. In particular, methods are provided for the separation of mono-carboxy substituted pro...
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WO/2006/105850A1 |
Novel acyl hydrazides of the formula (I), in which R1 - R9 have the meanings defined in claim 1, are SGK inhibitors and can be used for the treatment of SGK-induced diseases and conditions such as diabetes, obesity, metabolic syndrome (d...
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WO/2006/102760A1 |
This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I); wherein Y, L, Z, W, X, Q, R1, R2 and R3 are as defined in the specification.
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WO/2006/100502A1 |
There is provided a compound having Formula (I ) R1-Z-R2 wherein R1 is a group selected from optionally substituted fused polycyclic groups, substituted alkyl groups, branched alkyl groups, and optionally substituted cycioalkyl groups Z ...
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WO/2006/098308A1 |
An anthranilic acid derivative represented by the general formula below or a salt thereof: wherein R1 and R2 independently represent a hydrogen atom or the like; R3 represents a phenyl, cycloalkyl or bicyclic heterocyclic group which may...
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WO/2006/095670A1 |
Base-multiplying agents usable in crosslinking epoxy compounds and so on, which can react with a base to generate another base and which permit efficient progress of base multiplication reaction; and base-reactive curable compositions co...
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WO/2006/096159A1 |
The invention relates to control fungal growth on tanned hides, using cyanodithiocarbimates of formula (I): X is a halogen; R is a substituted or unsubstituted C1-C14 alkyl group, a substituted or unsubstituted C2-C14 alkenyl group, a su...
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WO/2006/087357A2 |
A new process is described, easy to perform on industrial scale, with high yield, for obtaining enantiomers of chrysanthemic acid starting from mixtures containing them. The process involves reacting said mixtures with enantiomers of 2- ...
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WO/2006/082978A1 |
It is intended to provide an acylamide compound represented by the following formula (1), a pro-drug thereof or a pharmaceutically acceptable salt thereof and an adiponectin inducer, an adiponectin secretion enhancer, a metabolic syndrom...
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WO/2006/082950A1 |
Disclosed is a method for producing 2,6-di-tert-butyl-4-mercaptophenol which comprises a step wherein bis(3,5-di-tert-butyl-4-hydroxyphenyl)polysulfide is reduced with zinc in a mixed solvent of toluene and an n-butanol. Also disclosed i...
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WO2006043149A9 |
The present patent application concerns new compounds of formula (I): displaying agonistic activity at sphingosine-1-phosphate (S1P) receptors, their process of preparation and their use as immunosuppressive agents.
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WO/2006/082228A1 |
The invention relates to a method for synthesising cysteine derivatives of formula I, wherein R1 is an alkyl radical, R2 is a radical selected from a group consisting of alkyl or aryl radicals and r3 is a radical selected from a group co...
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WO/2006/083266A1 |
In accordance with the present invention, compounds having formula (I), where the variables are as identified in the claims, that inhibit Type III protein secretion have been identified, and methods for their use provided. In one aspect ...
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WO/2006/079480A1 |
The invention relates to the use of thioether derivatives of formula (I) wherein: R1 is an unsubstituted or substituted (C1-C6) alkyl, A is a divalent unit taken from the group CO, CR3(OR4), CR3(O-CO-R4), CR3(COOR4), C(=CR3R4), C(=CR3R4)...
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WO/2006/079535A1 |
The invention relates to the production of a new salt form of valnemulin, a compound of formula I, which is notable for its good crystallinity in higher purity, its simpler technical usability and improved storage stability.
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WO/2006/079568A2 |
The invention relates to the use of an effective amount of at least one 3-sulfanylpropanamide compound of formula (I) or a salt and/or solvate thereof : (I) in which: a) R1 and R2 independently represent: a hydrogen atom; an optionally s...
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WO/2006/080477A1 |
Norvaline derivative of the formula [I] or pharmaceutically acceptable salt thereof, method for preparing the same, pharmaceutical composition containing the same, and use of said compound for inhibiting transporting activity of glycine ...
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