Title:
METHOD FOR PREPARING OPTICALLY ACTIVE 4-PHENYLTHIO-2-BUTANOL COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2007/025442
Kind Code:
A1
Abstract:
A method for preparing optically active 4-phenylthio-2-butanol compounds
is disclosed. The desired compounds are obtained by reacting propylene epoxides
with methallic reagents of formula R1-Ph-A-CH(R2)M, wherein
A is S, SO or SO2. The present method provides less by-products, ease
of purification of final products and a yield of over 80%. It can be conducted in
a simple manner so that it is suitable for industrial practice.
Inventors:
YANG XIAOLONG (CN)
LI QIANG (CN)
LIU XIANGQUN (CN)
LI QIANG (CN)
LIU XIANGQUN (CN)
Application Number:
PCT/CN2006/001807
Publication Date:
March 08, 2007
Filing Date:
July 21, 2006
Export Citation:
Assignee:
SHANGHAI JULONG PHARMACEUTICAL (CN)
YANG XIAOLONG (CN)
LI QIANG (CN)
LIU XIANGQUN (CN)
YANG XIAOLONG (CN)
LI QIANG (CN)
LIU XIANGQUN (CN)
International Classes:
C07C323/19
Other References:
RAWAL V.H. ET AL.: "alpha-METHOXYTHIOANISOLE. FURTHER USES AS AN UMPOLUNG REAGENT", SYNTHETIC COMMUNICATIONS, vol. 14, no. 12, 1984, pages 1129 - 1139, XP008078191
MARCZAK S. ET AL.: "LEWIS ACID-MEDIATED ADDITION OF LITHIATED ALKYL PHENYL SULPHONES AND OXIRANES. A METHOD FOR SYNTHESIS OF alpha,beta-UNSATURATED KETONES", SYNTHETIC COMMUNICATIONS, vol. 20, no. 10, 1990, pages 1511 - 1520, XP008078192
MARCZAK S. ET AL.: "LEWIS ACID-MEDIATED ADDITION OF LITHIATED ALKYL PHENYL SULPHONES AND OXIRANES. A METHOD FOR SYNTHESIS OF alpha,beta-UNSATURATED KETONES", SYNTHETIC COMMUNICATIONS, vol. 20, no. 10, 1990, pages 1511 - 1520, XP008078192
Attorney, Agent or Firm:
CHINA SINDA INTELLECTUAL PROPERTY LTD. (Focus Place 19 Financial Street, Beijing 2, CN)
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