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WO/2005/057714A1 |
It is aimed to obtain a lithium secondary battery with excellent characteristics such as energy density and electromotive force, which is also excellent in cycle life and shelf life stability. Disclosed is an electrolyte solution for sec...
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WO/2005/056518A1 |
This invention discloses a series of sulfur- or oxygen-containing oxime ether compounds represented by the general formula (I), in which R, R,, X, n, Ar and F, are as defined in the specification, and their preparation methods. The compo...
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WO2004046094A9 |
The present invention provides histone deacetylase inhibitors of general formula (I), process for the preparation of such compounds and uses of the compounds in medicine.
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WO/2005/054181A1 |
It is intended to provide a medicinal composition containing, as the active ingredient, a compound specifically binding to KSRP or a functional fragment thereof and a method of screening this compound. A composition capable of regulating...
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WO/2005/054180A1 |
A series of N-cycloalkylcarboxamide derivatives of N benzyl benzenesulfonamides of Formula I are described. The compounds inhibit β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other cond...
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WO2005007076B1 |
Certain N-deacetylcolchicine and N-deacetylthiocolchine derivatives are described wherein the 7-N position on the B ring is substituted with the group - C(O)-(CHR4)m-AR, wherein m is an integer of 0-10, A is S, O, N or a covalent bond; R...
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WO/2005/054176A1 |
The present invention is directed to a compound of formula (I), or a pharmaceutically acceptable salt, solvate hydrate or stereoisomer thereof, which is useful in treating or preventing disorders mediated by a peroxisome proliferator act...
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WO/2005/051898A2 |
The present invention relates to novel, non-secosteroidal, sulfonate and sulfonamide functional diaryl compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1&agr ,25 dihydroxy vitamin D3. These com...
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WO/2005/051947A1 |
The invention relates to novel macrocycles of general formula (I) and to the use thereof for treating cancerous diseases.
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WO/2005/051901A1 |
The present invention provides compounds having the strucutural formula (I) and methods for the treatment of cancer using compounds of formula (I).
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WO/2005/051896A1 |
The invention relates to a compound of the formula (I) in which: - R1 represents, independently of each other, a halogen atom; an aliphatic hydrocarbon-based group optionally substituted and/or optionally interrupted by one or more oxyge...
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WO/2005/051895A1 |
Disclosed are &dgr -amino-&gammad -hydroxy-&ohgr -aryl-alkanoic acid amide compounds of formula (I) and the salts thereof, having renin-inhibiting properties. Also disclosed are pharmaceutical compositions comprising these compounds and ...
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WO/2005/051888A2 |
The invention relates to compounds of the formula (I) in which: i and j=1; R1 is in position 3 or 4 on the phenyl ring and represents a cyano group, an alkoxy group substituted by halogen, a thioalkyl group, an alkylcarbonyl group or an ...
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WO/2005/051890A1 |
The present invention relates generally to novel therapeutic compounds and more particularly to novel compounds, their use as GPR40 agonists, processes for their manufacture, and intermediates useful in their preparation.
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WO/2005/049557A1 |
A process for producing an optically active 2-alkylcysteine or a salt thereof, characterized by comprising causing cells of a microorganism or a product of treatment of the cells, the microorganism having the ability to stereoselectively...
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WO/2005/048810A2 |
Novel benzamide compounds of Formula (I), Formula (II) and Formula (III, salts, water soluble salts, analogs and radiolabeled counterparts thereof as sigma-2 receptor radiotracers for imaging the proliferative status of solid tumors. A m...
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WO/2005/049870A1 |
The invention relates to a method for the extraction of keratin from dead animal skins, characterised in the treatment of dead animal skins with a substance of general formula (I), or at least one corresponding alkali metal, earth alkali...
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WO/2005/049593A2 |
Disclosed are N-acylsulfonamide compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which a...
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WO/2005/049594A1 |
Disclosed are N-acylsulfonamide compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which o...
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WO/2005/047231A1 |
The present invention relates to a novel trisubstituted cyclic thickener or gelator. The present invention further relates to a method for thickening or gelating a solution comprising the use of such a gelator or thickener. A gelator or ...
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WO/2005/047238A2 |
The invention relates to a method for synthesising, in an industrialised solid phase, novel diaryl sulphide compounds of formula (I). Said invention also relates to the purity of novel industrial useful products, to chemical compounds pr...
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WO/2005/047237A1 |
The invention relates to a method for synthesising, in an industrialised solid phase, novel diaryl sulphide compounds of formula (I). Said invention also relates to the purity of novel industrial useful products, to chemical compounds pr...
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WO/2005/044785A1 |
Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds...
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WO/2005/044780A1 |
An aminocarboxylic acid derivative represented by the general formula (1) (example: 3-amino-6-[4-(3-benzyloxyphenylsulfanyl)-2-chlorophenyl]-3-h
ydroxymethylhexanoic acid). It is highly effective in controlling a sphingosine-1-phosphoric...
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WO/2005/044007A1 |
A pesticide having stabilized high pesticidal effects for crop plants infected with plant diseases, is presented. The pesticide contains a biphenyl derivative represented by the formula (I) or its salt, as an active ingredient: wherein X...
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WO/2005/042476A2 |
The invention encompasses the novel compounds of Formula (I) and Formula (II), which are prodrugs that convert in vivo to diaryl-2-(5H)-furanones useful in the treatment of cyclooxygenase-2 mediated diseases. These prodrugs are far more ...
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WO/2005/042477A1 |
The invention relates to a method for the production of $g(a)-(3-arylthio)-acetophenones of general formula (I), wherein the substituents R1 and R2 independently represent C1-C6-alkyl, SiR33, and the substituent R3 represents a C1-C6-alk...
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WO/2005/042478A2 |
The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia.
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WO/2005/042479A1 |
The present invention is directed to an improved process for preparing modafinil wherein benzhydrylthioacetate is prepared in high yield and purity by the reaction of a haloacetate with the reaction product of thiourea and benzhydrol. Th...
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WO/2005/042442A2 |
Disclosed are the compounds 2-methylthio-1,4-naphthoquinone (MTN) and MTN derivatives of general formula (2) as well as methods for the production or isolation thereof. MTN and MTN derivatives have antitumor properties, especially antian...
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WO/2005/042464A1 |
Treatment of Diseases caused by Disturbances of the Activity of the Androgen Receptor uses of compounds of Formula (I): (as defined herein), for the treatment of diseases caused by disturbances of the activity of androgen receptor are pr...
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WO/2005/040104A1 |
The present invention relates to novel hypolipidemic, antiobesity, hypocholesterolemic and antidiabetic compounds. More particularly, the present invention relates to novel alkyl carboxylic acids of the general formula (I), their stereoi...
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WO/2005/040127A1 |
The present invention relates to novel compounds accelerating the activity of Peroxisome proliferator-activated receptor gamma (PPAR&gammad ) and alpha (PPAR&agr ), processes of preparing the same, and pharmaceutical compositions contain...
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WO/2005/040202A2 |
The present invention presents modules from which helical constraints can be built by very flexible strategies. The peptide bonds involved partially compensate the hydrophobic nature of the disulfide bonds, which are also included into t...
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WO/2005/037777A1 |
A process for producing bicalutamide, which is represented by the formula (4), (4) which comprises: a step (A) in which the compound represented by the formula (1) is reacted with a peroxycarboxylic acid to obtain the compound (2) repres...
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WO/2005/037779A2 |
The invention relates to medicinally used substances which specifically inhibit peptidases splitting Gly-Pro-p-nitroanilide. The invention further relates to the use of at least one such substance or at least one pharmaceutical or cosmet...
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WO/2005/037269A1 |
A compound represented by the following formula (1), a prodrug thereof, or a pharmaceutically acceptable salt of either. They are effective in enhancing LDL receptor manifestation and are useful as a therapeutic agent for hyperlipemia, a...
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WO/2005/037208A2 |
Disclosed are aryl, heteroaromatic and bicyclic aryl nitrone compounds and pharmaceutical compositions containing such derivatives. The disclosed compositions are useful for preventing and/or treating pain, neurodegenerative, autoimmune ...
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WO/2005/037763A1 |
The present invention is directed to a compound of formula (I), or a pharmaceutically acceptable salt, solvate, hydrate or stereoisomer thereof, which is useful in treating or preventing disorders mediated by a peroxisome proliferator ac...
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WO/2005/037205A2 |
The present invention relates to a novel class of anti-cancer compounds, which contain a haloacetamide or azide moiety and are, in one embodiment, alkylating agents. These agents, either alone or in a composition, are useful for treating...
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WO/2005/037771A2 |
An O-substituted hydroxylamine having the following general formula : R1-CHX-O-NH2, wherein X is hydrogen or an alkyl; and R1 is an unsubstituted or substituted phenyl, thienyl, furanyl, pyrrolyl or -CR2=C3R4; wherein R2, R3 and R4 are h...
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WO/2005/037206A2 |
The present invention relates to a novel class of anti-cancer compounds which selectively target androgen receptor (AR)-expressing cancer, cells, such as prostate cancer cells and breast cancer cells, These agents comprise an androgen re...
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WO/2005/034960A1 |
Compounds and methods are provided for treating patients suffering from health condition associated with an expression state of a gene such as fertility disorders, cancer, proliferative dis5ases, vascular diseases, wounds requiring thera...
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WO/2005/035553A2 |
Methods for the selective conjugation of peptides which comprises an enzymatic incorporation of a functional group at the C-terminal end of a peptide followed by reaction with a second compound comprising the moiety to be conjugated to t...
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WO/2005/035565A1 |
The invention provides derivatives of IL-21 or variants thereof.
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WO/2005/034988A1 |
Sustained release formulations comprising molecules modified so as to have a reduced clearance are provided.
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WO/2005/035514A2 |
The present invention provides compounds of Formula (I) useful as modulators of ABC transporter activity, or a pharmaceutically acceptable salt thereof, wherein RB, n, B, RC, RD, RE, A, and Z are described generally and in classes and su...
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WO/2005/035486A1 |
The invention relates to 2-cyanobenzenesulfonamide compounds of the formula (I) where the variables R1 to R5 are as defined in claim 1 and/or to their agriculturally useful salts. Moreover, the present invention relates to the use of c...
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WO/2005/033070A2 |
The invention relates to a method for the production of bisepoxides, characterised in that a conjugated diene of formula (I) is reacted with at least one peroxide with the application of up to 4 equivalents of peroxide per C-C double bon...
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WO/2005/030699A1 |
A novel agricultural chemical, especially an insecticide or acaricide. It is a pest control agent containing either a substituted benzanilide compound represented by the general formula (1): [wherein W1 and W2 each represents oxygen, etc...
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