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WO/2004/074256A1 |
Compounds of formula (I): (I)are effective in the treatment of protein tyrosine phosphatase (PTPase) mediated disorder such as diabetes.
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WO/2004/072022A1 |
The invention relates to novel compounds which correspond to the following general formula (I): their method of preparation, and their use in pharmaceutical compositions intended for use in human or veterinary medicine (in dermatology an...
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WO/2004/069241A1 |
The invention relates to the use of acylglycerols and the nitrogen- and sulphur-containing analogues thereof in therapy, particularly for the treatment of cerebral ischemia. The invention further relates to methods for preparation of sai...
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WO/2004/069823A1 |
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell pr...
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WO2004048320B1 |
Biguanide and dihydrotriazine derivatives, preferably substituted asymmetrical imidodicarbonimidic diamides derived from hydroxylamines, and compositions containing biguanide and dihydrotriazine derivatives are disclosed. In addition, me...
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WO/2004/065353A1 |
The present invention is related to a compound of formula (I): A-B-E-D (I), wherein: A is selected from the group consisting Ra-L1-K-L2; and (II) B is either present or absent, but if B is present then B is (III), E is (IV), D is selecte...
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WO/2004/062622A2 |
A probucol or a probucol derivative can be efficiently converted to a monoester or monoether of probucol by reacting the free hydroxyl-containing probucol or a derivative thereof (by which is meant a probucol compound with at least one s...
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WO/2004/063129A2 |
A novel, convenient and efficient method for trifluoromethylation of substrate compounds is disclosed. Particularly, alkoxide and hydroxide induced nucleophilic trifluoromethylation of carbonyl compounds, disulfides and other electrophil...
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WO2004026816B1 |
The present invention is directed to selective LXR modulators, small molecule compounds corresponding to Formula (I) and is further directed to a process of treating a condition in a mammal that is modulated by LXR using a therapeuticall...
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WO/2004/062633A1 |
The invention relates to novel hair care compositions comprising bis-pantoyl-cystamine or a derivative thereof.
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WO/2004/063148A1 |
The present invention relates to a compound of the formula ((I): in which: n is an integer chosen from 1, 2 and 3; Y represents O; N-OR9, in which R9 represents H or a saturated hydrocarbon-based aliphatic group; CR10R11, in which R10 an...
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WO/2004/063149A1 |
Method for preparing methyl 2-diphenylmethylsulfinylacetate (MDMSA) comprising the steps of :(i) conversion of benzhydrol into methyldiphenylmethylthio-acetate ; and (ii) conversion of methyldiphenylmethylthioacetate into methyl-2-diphen...
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WO/2004/062601A2 |
Antibacterial compounds of formula (I) are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infectio...
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WO/2004/060859A2 |
Compounds of formula (I) are useful for increasing cGMP levels in a mammal.
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WO/2004/060885A1 |
A process for easily producing from an inexpensive material an optically active 2-thiomethyl-3-phenylpropionic acid derivative useful as an intermediate for medicines. An optically active 2-hydroxymethyl-3-phenylpropionic ester derivativ...
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WO/2004/058682A1 |
Compounds represented by the general formula (I), salts thereof, and hydrates of both: (I) wherein T is a single bond, optionally substituted C1-4 alkylene, or the like; the symbols &dot &dot &dot &dot &dot &dot are each a single bond or...
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WO/2004/058747A1 |
The present invention provides compounds capable of binding to an Fc receptor and modulating Fc receptor activity comprising a core lipophilic group in the form of an Aryl ring substituted with a group rich in p-electrons. The invention ...
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WO/2004/056365A2 |
A compound of formula (I): wherein R1, R2, R3 and Y are as defined herein, or a pharmaceutically-acceptable and -cleavable ester, or acid addition salt thereof, useful for promoting the release of parathyroid hormone, e.g. for preventing...
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WO/2004/056766A1 |
The present invention relates to compounds that inhibit TACE, compositions thereof, and methods of using those compounds and compositions for treating diseases.
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WO/2004/056740A1 |
A novel class of dicarboxylic acid derivatives, the use of these compounds as phar-maceutical compositions, pharmaceutical compositions comprising the compounds and meth-ods of treatment employing these compounds and compositions. The pr...
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WO/2004/056777A1 |
The present invention provides inhibitors of microsomal triglyceride transfer protein (MTP) and/or apolipoprotein B (Apo B) secretion having Formula (I) which are useful for the treatment of obesity and related diseases, as well as preve...
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WO/2004/056763A2 |
Novel compounds that act to antagonize the action of the glucagon peptide hormone on the glucagon receptor. More particularly, it relates to glucagon antagonists or inverse agonists.
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WO/2004/052848A1 |
The present invention relates to a melanin concentrating hormone antagonist compound of Formula I: (I) wherein Ar1, Ar2, Ar3, L1, L2 and Q areas defined, or a pharmaceutically acceptable salt, solvate, enantiomer or mixture of diastereom...
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WO/2004/052846A1 |
This invention relates to tetrahydro-naphthalene derivatives and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The tetrahydro-naphthalene derivatives of the present invention have an excellent acti...
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WO/2004/052847A2 |
The present invention relates to methods of treating pathological disorders susceptible to steroid hormone nuclear receptor modulation comprising administering to a patient in need thereof an effective amount of a compound of the formula...
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WO/2004/052872A1 |
ABSTRACT A novel haloalkene compound represented by the formula (I), useful as an active ingredient of a pesticide, is presented: wherein each of X¿1? and X¿2? is halogen, Y is a hydrogen atom, halogen, alkyl or the like, n is from 0 t...
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WO/2004/050671A1 |
The invention relates to liquid sulphur-containing antioxidants obtainable by reacting at least compound of formula (I) with at least one compound of formula (II) and at least one compound of formula (III) where the variables are as defi...
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WO/2004/047772A2 |
The invention provides small molecules that act as catalytic antioxidants and methods of use thereof. The compounds can repeatedly bind and destroy reactive oxygen species by serving as substates for enzymes of the methionine sulfoxide r...
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WO/2004/048319A1 |
Novel compounds of Formula I which modulate MCH activity are disclosed, in which A is a linker, Ar, is an aryl or heteroaryl group; R1 is hydrogen or a lower alkoxy group; Q together with the carbonyl forms an amide group, which is furth...
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WO/2004/048322A1 |
A compound of the formula (I) or a pharmaceutically acceptable salt or solvate thereof, wherein:R1, R2, L1, L2, M1, M2, n, p, q, A, D, X, Y and Z are as described in the specification; pharmaceutical compositions thereof, methods of maki...
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WO/2004/045601A1 |
The present invention relates to norketamine and ketamine/norketamine prodrugs, and methods of their use and analgesics. More particulary, the invention relates to norketamine and N-conjugated prodrugs of ketamine and norketamine, and me...
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WO/2004/046162A2 |
ABSTRACT Potent non-steroidal farnesoid X receptor (FXR) agonists are N-aryl-N-arylmethyl amido and ureido compounds having the chemical structure represented by the following formula (I): INSERT FORMULA wherein E1 is (C1-C8)alkyl, cyclo...
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WO/2004/046091A2 |
The invention relates to novel biaromatic compounds which correspond to the general formula (I), and also to a process for preparing them and to their use in pharmaceutical compositions intended for use in human or veterinary medicine (i...
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WO/2004/046096A2 |
The invention relates to novel compounds corresponding to formula (I) below: and to the method for preparing them, and to their use in pharmaceutical compositions intended for use in human or veterinary medicine, or alternatively in cosm...
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WO/2004/043380A2 |
The present invention relates to compounds and related technetium and rhenium complexes thereof which are suitable for imaging or therapeutic treatment of tissues, organs, or tumors. In another embodiment, the invention relates the metho...
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WO/2004/043911A2 |
This invention relates generally to N-cycloalkylglycines of the Formula (I): or a stereoisomeric form, a mixture of stereoisomeric forms, or a pharmaceutically acceptable salt thereof, which are useful as HIV protease inhibitors, pharmac...
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WO/2004/043903A1 |
There is provided a compound of formula (I) wherein A is selected from -O- and -S-; X is selected from phenyl optionally substituted with up to 5 substituents each independently selected from halo, C1-C4 alkyl and C1-C4 alkoxy, thienyl o...
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WO/2004/041266A1 |
A GPR40 receptor function controlling agent which contains a compound having an aromatic ring and a group capable of releasing a cation and is useful as a insulin secretion promoting agent or a preventive/remedy for diabetes, etc.
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WO/2004/039771A1 |
The present invention relates to a novel diallyldisulphide derivative having formula I as shown herebelow and their pharmaceutically acceptable salts; R-CH = CH - CH2-S-S-CH2-CH = CH-R (Formula I)wherein R=C6HnXp[when n = 3 to 5, p = 2 t...
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WO/2004/039772A1 |
The instant invetion provides a process for the preparation of S-(2-aminoethyl)-2-methyl-L-cysteine comprised of the steps of (i) esterification of 2-methyl-L-cystene; (ii) alkylation of the cysteine ester of step (i) to provide an N-pro...
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WO/2004/037777A1 |
The invention features tetralin and indane compounds of Formula I, compositions containing them, and methods of using them as PPAR alpha modulators to treat or inhibit the progression of, for example, diabetes.
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WO/2004/037778A1 |
The invention features tetralin and indane compounds, compositions containing them, and methods of using them as PPAR alpha modulators to treat or inhibit the progression of, for example, dyslipidemia.
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WO/2004/037774A1 |
Process for the Production of 3-methylthiopropanal. A process for the production of 3-methylthiopropanal which reacting reaction medium comprising methyl mercaptan and acrolein in the presence of a catalyst comprising an organic base cha...
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WO2002057222A9 |
This invention relates to thiol compounds of the formulae I, II or III (in which the variables are as defined in the claims), pharmaceutical compositions and diagnostic kits comprising such compounds and methods of using such compounds f...
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WO/2004/037773A1 |
The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of...
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WO/2004/037779A1 |
This invention features tetralin and indane compounds, compositions containing them, and methods of using them as PPAR alpha modulators to treat or inhibit the progression of, for example, diabetes.
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WO2002004413A9 |
The invention provides enantiomers of ajoene and derivtives of Z(-)-ajoene. The derivative of Z(-)-ajoene are useful for modulating integrin-mediated functions, for treating disorders, diseases or conditions in which integrins play a rol...
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WO/2004/037775A1 |
Novel compounds of the general formula (I), the use of these compounds as pharma-ceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present...
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WO/2004/037776A2 |
Novel compounds of the general formula (I), the use of these compounds as pharma-ceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present...
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WO/2004/033424A1 |
The present invention relates to propofol derivatives comprising a cyclic or linear amino acid, or a poly- or (oligo)saccharide moiety, a process for preparing said derivatives, a method for anesthetizing a mammal as well as a method for...
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