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WO/2004/005243A2 |
The invention concerns compositions comprising substituted 1,3-diphenylprop-2-en-1-one derivatives designed for therapeutic use. The inventive compositions are useful in particular for preventing or treating cardiovascular diseases, synd...
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WO/2004/004659A2 |
Synthetic alkaloid derivatives useful as inhibitors of acyl gluc osaminyl inositol amidase activity, including mycothiol-S-conjugate amidase, are disclosed. In addition, methods of using the inhibitors of acyl glucosaminyl inositol amida...
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WO/2004/002951A2 |
The invention concerns a method for synthesis of hydrogenofluoromethylenesulphonyl radical derivatives, comprising: a) a step which consists in condensing a thiolate (that is a monoalkyl sulphide salt) with a compound having a sp3 hybrid...
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WO/2004/002944A1 |
The present invention provides compounds of Formula I, compositions and methods that are useful for treating viral infections and associated diseases, particularly HCV infections and associated diseases.
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WO/2004/002939A2 |
The present invention relates to a compound formula [I]: Y is bond, -0-(CH2)n- (in which n is 1, 2, 3 or 4), etc., Z is cyano, tetrazolyl, etc., R1 is hydrogen, lower alkyl, etc., R2 is hydrogen or an amino protective group, R3 is hydrog...
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WO/2004/002491A1 |
The present invention relates to novel cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
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WO/2004/002940A1 |
The present invention provides compounds of Formula I, compositions and methods that are useful for treating viral infections and associated diseases, particularly HCV infections and associated diseases.
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WO/2004/000781A2 |
New compounds able to release COX-2 inhibitors and NO having formula (I):M-T-YA-NO2 (I) for the treatment and/or prophylaxis of inflammatory processes.
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WO/2004/000295A1 |
A compound of formula (I) wherein R1 represents aryl optionally substituted by a heterocyclic group or a heterocyclic group optionally substituted by aryl wherein each aryl or heterocyclic group is optionally substituted; the group -(CH2...
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WO/2004/000215A2 |
In accordance with the present invention, there are provided novel chemical entities which have multiple utilities, e.g., as prodrugs of NSAIDs; as dual inhibitors of cyclooxygenase (COX) and 5-lipoxygenase (5-LO); as anticancer agents (...
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WO/2004/000854A1 |
The present invention provides a lipid compound comprising at least one non-polar moiety and a polar moiety, wherein each or at least one non-polar moiety is of the formula X-Y-Z-, wherein X is a hydrocarbyl chain, Y is selected from at ...
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WO/2004/000790A1 |
The present invention provides a compound of formula (I), wherein n is 0, 1 or 2 and R1 represents halo, a C1-4alkyl group which is optionally substituted by one or more fluoro, a C1-4alkoxy group which is optionally substituted by one o...
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WO/2004/000793A2 |
The invention relates to compounds of the general formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R8’, R9, W, a, b and n have the significances given in claim 1, and optionally the enantiomers thereof. The active ingredients have ...
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WO/2004/000315A1 |
The present invention provides a compound of formula (I):wherein:R1 and R2 are independently H or C1-3 alkyl;X represents a O or (CH2)n where n is 0, 1 or 2;R3and R4 independently represent H, C1-3 alkyl, -OCH3, -CF3, allyl, or halogen;X...
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WO/2004/000294A1 |
The present invention provides a compound of formula (I), wherein n is 0, 1 or 2; R1 represents halo, a C1-4alkyl group which is optionally substituted by one or more fluoro, a C1-4alkoxy group which is optionally substituted by one or m...
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WO/2004/000762A2 |
A compound of formula (I) or a pharmaceutically acceptable salt, solvate, or hydrolysable ester thereof, .Wherein:R1 and R2 are independently hydrogen or C1-3 alkyl;X represents a bond, CH2 or O;R3 and R4 are independently hydrogen, C1-6...
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WO/2004/000797A1 |
The invention relates to &agr -sulfonylamino-acetonitrile derivatives of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein Ar1, and Ar2 independently of each other stand for an optionally...
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WO/2004/000796A1 |
Novel phthalamide derivatives of the formula (I) (I)wherein R1, R2, R3, R4, and R5 have the meanings given in the description, processes for their preparation, and their use as insecticidal agents in agricultural and horticultural field.
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WO/2003/106410A1 |
Fluorinated cycloalkyl-derivatised benzoylguanidines of formula (I) are suitable for use as anti-arrhythmic medicaments comprising cardioprotective components for the prophylaxis and treatment of infarcts and also for the treatment of an...
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WO/2003/106442A1 |
The present invention provides a process for preparing thiazole derivatives of formula (XI), that activate the delta subtype of the human Peroxisome Proliferator Activated Receptor (hPPAR$g(d)), and also provides processes for compounds ...
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WO/2003/106689A1 |
It is intended to provide a process for conveniently producing on an industrial scale an optically active &agr -methylcysteine derivative or its salt in the form of an L- or D-compound, which is useful as an intermediate of a drug, etc.,...
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WO/2003/106550A2 |
Organic thiol compounds including mercaptophenylcarboxylates are disclosed which can be utilized to plasticize and/or stabilize halogen- containing polymer compositions, especially polyvinyl chloride) compositions. Compounds of the prese...
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WO/2003/103651A1 |
The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for...
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WO/2003/104178A1 |
Where Y, R¿1?-R¿8? and R¿101?-R¿108? are as defined in the specification. Compounds of formula (II) and methods of inhibiting the cytokine or biological activity of Macrophage Migrating Inhibitory Factor (MIF) comprising contacting M...
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WO/2003/103660A1 |
Compounds of Formula I, wherein R1-R8 are defined herein are provided, together with pharmaceutically acceptable salts, hydrates, metabolites, and/or prodrugs thereof. Uses of these compounds for inhibiting beta amyloid production and fo...
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WO/2003/103602A2 |
The invention describes novel nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) selective inhibitor, and, o...
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WO/2003/101944A1 |
A process for producing a compound of the general formula (IV) or a salt or solvate thereof, characterized in that a compound of the general formula (V) or a salt or solvate thereof is subjected to reaction for conversion to an alkylthio...
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WO/2003/101948A2 |
The present invention provides novel compounds that bind selectively to cells undergoing perturbations and alterations of the normal organization of their plasma membrane, while binding to a lesser degree to cells having membranes of nor...
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WO/2003/101941A2 |
Disclosed herein is a compound represented by Structural Formula (I). R1 is a substituted or unsubstituted aryl group or alkyl group; R2 is a substituted or unsubstituted aryl group or cycloalkyl group; Ar is a substituted or unsubstitut...
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WO/2003/101425A2 |
Hydrophilic polymeric articles comprising a polymeric scaffold covalently attached to one or more therapeutic agents, such as drug or drug-conjugate molecules. The articles may further covalently attached comprise recognition elements (R...
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WO/2003/101937A1 |
Synthetic methods are disclosed for the production from glucose of analogs of sphingosine, azidosphingosine, ceramides, lactosyl ceramides, glycosyl phytosphingosine, and enantiomeric derivatives of phytosphingosine and/or its homologues...
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WO/2003/101945A1 |
Novel ligands that are inhibitors of the RAR receptors, process for preparing them and use thereof in human medicine and in cosmetics. The invention relates to novel bicyclic compounds corresponding to the general formula (I) and to the ...
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WO/2003/102693A1 |
A novel liquid photoreactive asymmetric acrylate compound containing sulfur, aromatic moieties, and optionally bromine, and having high dynamic range sensitivity is disclosed. The acrylate compound is a monomer for a photoimageable syste...
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WO/2003/101382A2 |
This invention relates to compounds of formula (I), and a method for treating anthrax or inhibiting lethal factor by administrating a composition containing a compound of formula (I) and a pharmaceutically acceptable carrier. This invent...
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WO/2003/099774A1 |
The present invention provides processes for the preparation of modafinil which includes the step of reacting benzhydrylthiol and chloroacetamide.
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WO/2003/099763A1 |
This invention relates to N-acylamino aryl derivatives of the general formula (I), wherein R1 is halogen, halogen-(C1-C6)-alkyl, cyano, C1-C6-alkoxy or halogen-(C1-C6)-alkoxy; R21, R22, R23 and R24 independently from each other are selec...
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WO/2003/099773A1 |
The invention relates to compounds represented by Structural Formula I, which can bind to CCR9 receptors and block the binding of a ligand (e.g., TECK) to the receptors. The invention also relates to a method of inhibiting a function of ...
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WO/2003/099409A1 |
The invention concerns a method for producing specific crystalline modifications of an organic polymorphous substance. In accordance with said method, the specific crystalline modification is obtained by precipitation from a salt of the ...
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WO/2003/099810A2 |
The present invention provides novel radiopharmaceuticals useful for the diagnosis of infection and inflammation, reagents and kits useful for preparing the radiopharmaceuticals, methods of imaging sites of infection and/or inflammation ...
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WO/2003/099777A1 |
The present invention relates to a novel process for the preparation of compounds of the formula (I) (I)by reacting in a first step amino alcohols of the formula (II) (II)with oleum to give sulphuric acid esters of the general formula (I...
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WO/2003/097582A2 |
Benzonitrites and benzimidates represent important intermediates and starting materials, which are typically not commercially available. The present invention discloses a facile synthesis for 2,4-dihydroxybenzonitrile, and ethers and die...
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WO/2003/096978A2 |
This invention provides a compound having the structure: (I) This invention also provides for related compounds and pharmaceutical compositions. This invention further provides for a compound that can be used for non-invasive method for ...
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WO/2003/097568A1 |
A process for producing a 4-phenyl-4-oxo-2-butenoic ester derivative, characterized by simultaneously or continuously reacting a sulfuric ester, aromatic hydrocarbon, and maleic anhydride derivative. By the process, a 4-phenyl-4-oxo-2-bu...
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WO/2003/097575A2 |
The invention provides novel amino-functionalised chalcone derivatives and analogues thereof. Use of the compounds, or compositions comprising them, as pharmaceutically active agents, in particular against bacterial and parasitic infecti...
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WO/2003/097576A2 |
The invention provides novel diamino-functionalised chalcone derivatives and analogues thereof. Use of the compounds, or compositions comprising them, as pharmaceutically active agents, in particular against bacterial and parasitic infec...
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WO/2003/097574A2 |
The invention provides novel alkoxyaminochalcone derivatives and analogues thereof. Use of the compounds, or compositions comprising them, as pharmaceutically active agents, in particular against bacterial and parasitic infections, is al...
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WO/2003/096989A2 |
Methods and compositions for treating disease caused by infectious agents, particularly tuberculosis. In particular, methods and compositions comprising substituted ethylene diamines for the treatment of infectious diseases are provided....
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WO/2003/097622A2 |
The present invention provides methods of preparing 2-alkylcysteine derivatives, many of which can be performed stereoselectively. The present invention also discloses a method of preparing a class of iron chelating agents related to des...
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WO/2003/097792A2 |
A substrate comprises a surface, and a plurality of moieties, on at least a portion of the surface. The moieties are moieties of formula: Surf-L-Q-T, where -T comprises a reactant ligand, and Surf-designates where the moiety attaches to ...
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WO2003066572B1 |
The invention provides novel polyamine compounds and pharmaceutical compositions for administration in conjunction with cancer chemotherapy or radiation therapy. The compounds are administered locally to provide protection against the ad...
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