| Document |
Document Title |
|
WO/2002/030947A2 |
Compositions and methods of preparing amino acid chelates and complexes without added water are disclosed. In certain embodiments, the compositions prepared are free of interfering ions, and optionally, electrically neutral. More particu...
|
|
WO/2002/030918A2 |
Process for the synthesis of R(+)$g(a)-lipoic acid comprising the following stages: a) Salifying of racemic thioctic acid with R(+)$g(a)-methylbenzylamine; b) separation by filtration of the crystallized diastereoisomeric salt of R(+)$g(...
|
|
WO/2002/030929A1 |
Pleuromutilin compounds of the formula (A) & (B) are of use in anti-bacterial therapy.
|
|
WO/2002/030885A2 |
Alkanethiols of formula (1) and the enantimomers of the alkanethiol of formula (1), and disulfides of formula (3) and the anantimomers of the disulfide of formula (3), where -T is a moiety of formula (2) R?1¿ and R?2¿ are each individu...
|
|
WO/2002/030866A1 |
Use for the treatment of diseases having an inflammatory basis of compounds or salts thereof, having the following general formula (I): A-X¿1?-L-(W)¿p?-NO¿2? wherein A contains the radical of a drug, X¿1? and W are bivalent radicals,...
|
|
WO/2002/030874A2 |
The present invention relates to compounds of the general formula (I), (I)processes for their preparation, pharmaceutical compositions containing them as well as their use for the production of pharmaceutical compositions for the treatme...
|
|
WO/2002/028815A1 |
A compound of the formula in which R?1¿ and R?2¿ are each hydrogen or C¿1-4? alkyl, or R1 and R2 together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl or morpholino group...
|
|
WO/2002/028820A1 |
The present invention relates to a compound of formula (I) in which X, A, T, Y, G and R are as defined in Claim (1).
|
|
WO/2002/028810A2 |
The current invention provides novel retinoid compounds and methods for their synthesis, the use of such compounds for the preparation of medicaments for treating or preventing emphysema, cancer and dermatological disorders, methods for ...
|
|
WO/2002/028808A1 |
This invention provides analogs of triptycene which are useful as anticancer drugs, as well as for other uses. The potency of these compounds is in a similar magnitude as daunomycin, a currently used anticancer drug. Each compound of the...
|
|
WO/2002/028821A2 |
The invention relates to the PPAR-alpha activating compounds of general formula (I), for treating for example coronary heart diseases, and to a method for producing said compounds, wherein R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿,...
|
|
WO/2002/028881A1 |
This invention is directed to methods for providing sustained systemic concentrations of therapeutic or prophylactic agents such as GABA analogs following oral administration to animals. This invention is also directed to compounds and p...
|
|
WO/2002/028829A2 |
The invention is directed to a novel class of compounds, which inhibits peptide deformylase, pharmaceutical compositions containing compounds that inhibit peptide deformylase, and method of treating various infections.
|
|
WO/2002/026703A1 |
This invention pertains to certain active carbamic acid compounds which inhibit HDAC activity and which have the following formula(I) wherein: A is an aryl group; Q?1¿ is a covalent bond or an aryl leader group; J is an amide linkage se...
|
|
WO/2002/024638A1 |
The present invention provides an improved process for the preparation of N-(substituted phenyl)-3-alkyl-, aryl- and heteroarylsulfonyl-2-hydroxy-2-alkyl- and haloalkylpropanamide compounds of formula I (I), The formula I compounds exhib...
|
|
WO/2002/024632A2 |
The invention relates to a compound of formula (I), wherein all variables are as defined herein, and pharmaceutically acceptable salts or solvates thereof. The compounds of formula (I) are useful as LXR agonists.
|
|
WO/2002/024636A2 |
N-Benzoyl arylsulfonamides having the formula (I) are BCL-Xl inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-Xl inhibiting compositions and methods of promoting apoptosis in a mammal.
|
|
WO/2002/022556A1 |
Amide derivatives represented by the following general formula (1) which have a C5$g(a) receptor antagonism, wherein each symbol has the meaning as defined in the description. These amide derivatives, optically active isomers thereof or ...
|
|
WO/2002/022569A1 |
The invention relates to a method for producing chiral compounds according to the condition of a 1.4 Michael reaction in addition to a compound of general formula (31) and the use thereof as an antalgic.
|
|
WO/2002/022554A1 |
Processes for preparing N-methyl-L-alanine derivatives and novel intermediates of the process. The derivatives and intermediates are useful for preparing cell-binding agent/maytansinoid complexes.
|
|
WO/2002/022568A1 |
The invention relates to thio-$g(a)-amino acids of general formula (I), wherein R?1¿, R?2¿ and R?3¿ have the meanings given in the description, to methods for producing them, to medicaments containing these compounds and to the use of...
|
|
WO/2002/022627A2 |
The present invention relates to novel compounds and formulations thereof which compounds are ligands, e.g., agonists or antagonists, for a metabotropic glutamate receptor or a NAALADase enzyme or both. The present invention also relates...
|
|
WO/2002/022567A1 |
The present invention relates to antifungal compounds having the structural formula (I) in which X is S, SO, SO¿2?, or S(O)(NR?1¿) and the other variables are as defined in the claims; and pharmaceutically acceptable salts, solvates an...
|
|
WO/2002/022529A2 |
Pesticidal 1,4-diaryl-2,3-difluoro-2-butene compounds of formula (I) wherein Ar is phenyl, 1- or 2-naphtyl or a 5- or 6-membered heteroaromatic ring all of which aromatic systems may be optionally substituted; is C2-C6-alkenyl, C4-C6-cyc...
|
|
WO/2002/020462A1 |
Benzoic acid derivatives represented by the following general formula (I) and nontoxic salts thereof wherein R?1¿ represents COOH, COOR?6¿, etc.; A and B each represents a carbon ring or a heterocycle; R?2¿ represents alkyl, alkenyl, ...
|
|
WO/2002/018417A1 |
The invention is directed to nucleophile-stable thioester generating compounds comprising an orthothioloester or a carboxyester thiol, methods of production and use. The compounds and methods have wide applicability in organic synthesis,...
|
|
WO/2002/018323A2 |
Compound of formula (I) or therapeutically acceptable salts thereof, are protein tyrosine kinase PTP1B inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are dis...
|
|
WO/2002/017712A2 |
Compounds of formula (I): wherein A, B, D, and R are as defined herein and their agriculturally acceptable salts are disclosed as effective insecticides. In addition, compositions comprising an insecticidally effective amount of a compou...
|
|
WO/2002/018333A1 |
A compound of general formula (I) wherein R?1¿ and R?2¿ are H, C¿1?-C¿6?alkyl or (CH¿2?)¿d?(C¿3?-C¿6?cycloalkyl) wherein d = 0, 1, 2 or 3; or R?1¿ and R?2¿ together with the nitrogen to which they are attached from an azetidine...
|
|
WO/2002/016311A1 |
Carboxylic acid derivatives represented by the following general formula (I) and nontoxic salts thereof: (I) wherein R?1¿ represents COOH, COOR?6¿, etc.; A represents alkylene, etc.; R?2¿ represents alkyl, alkenyl, alkynyl, etc.; B re...
|
|
WO/2002/016316A1 |
The invention provides for a non-steroidal compound having the formula [I], wherein R?e¿ and 'R?e¿ are OH, optionally independently etherified or esterified; Z is -CH¿2?- or -CH¿2?CH¿2?-; R?1¿ is H, halogen, CF¿3?, or (1C-4C)alkyl...
|
|
WO/2002/014336A1 |
In ruthenium complexes of general formula A or B, X?1¿, X?2¿ independently represent single or multidentate anionic ligands; R, R', R'' independently represent hydrogen or optionally substituted C¿1-20?-alkyl, C¿6-20?-aryl or C¿7-20...
|
|
WO/2002/014265A1 |
Urea derivatives represented by the following general formula (1) or pharmaceutically acceptable salts thereof: (1) wherein each symbol is as defined in the description. Because of having a C5a receptor antagonism, these compounds are us...
|
|
WO/2002/014261A2 |
Compounds of general formula (I), in which: X represents a bond, O, S, SO or SO¿2?; and R?1¿ represents a (1-10C)alkyl, (2-10C)alkenyl, (2-10C)alkynyl, (4-10C)alkadienyl, carboxamido(1-8C)alkyl or aminocarbonyl(1-8C)alkyl group which i...
|
|
WO/2002/014263A1 |
Acylacetonitriles represented by the general formula (1): (1) [wherein R?1¿ is C(O)ZR?2¿; R?2¿ is C¿1-6? alkyl, C¿1-4? haloalkyl, or the like; Z is oxygen or sulfur; X and Y are each halogeno, C¿1-6? alkyl, or C¿1-4? haloalkyl; an...
|
|
WO/2002/014260A1 |
The invention provides a process for the preparation of racemic amino acids, characterized in that an acylamino acid of the general formula R?1¿-CH(NH-CO-R?2¿)COOH wherein R?1¿ is hydrogen, a linear, branched or cyclic alkyl radical t...
|
|
WO/2002/012224A2 |
Substituted N-substituted alkoxyphenyl compounds, compositions containing them, and methods of making and using them.
|
|
WO/2002/012166A2 |
The invention provides triamine derivative melanocortin receptor ligands of the formula (1), wherein R?1¿ to R?8¿ and n have the meanings provided herein. The invention further provides methods of using the ligands to alter or regulate...
|
|
WO/2002/012190A2 |
Substituted non-imidazole aryloxypiperidine compounds, compositions containing them, and methods of making and using them to treat or prevent histamine-mediated conditions.
|
|
WO/2002/012214A2 |
Substituted aryloxyalkylamines of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
|
|
WO/2002/010151A2 |
The invention relates to a method for producing R-lipoic acid and S-lipoic acid comprising a step selected from the following: (a) distillation of dihydrolipoic acid, (b) reaction of (2) or the stereoisomer thereof, wherein Ms represents...
|
|
WO/2002/010146A1 |
Compounds of formula (I) in which: each A is independently hydrogen, C¿1-6?alkyl optionally substituted by hydroxyl, C¿1-6?alkoxy, C¿1-6?alkenyl or C¿1-6?acyl group or a halogen atom or hydroxyl, CN or CF¿3? group; R3 is hydrogen, m...
|
|
WO/2002/009651A2 |
This invention relates to the use of compounds as inhibitors of the fatty acid synthase FabH.
|
|
WO/2002/008181A1 |
A process for producing 2-hydroxy-4-methylthiobutanoic acid which comprises hydrating 2-hydroxy-4-methylthiobutanenitrile in the presence of sulfuric acid, hydrolyzing the 2-hydroxy-4-methylthiobutanamide contained in the reaction mixtur...
|
|
WO/2002/008174A1 |
Novel mono- and dihydroxy phenylethylamine derivatives useful in treating melanoma are provided having the formulae (Ia, Ib or Ic). In the above formulae, R?a¿ is hydrogen or -COOR?b¿, R?b¿ is hydrogen or C¿1-6? alkyl; R?e¿ and R?eÂ...
|
|
WO/2002/008180A1 |
The invention provides bis(4-mercaptophenyl) sulfide derivatives of the general formula (1) which are monomers capable of forming dielectric films suitable for electronic components, a process for the preparation of the derivatives, and ...
|
|
WO/2002/006216A1 |
The invention concerns a novel method for industrial preparation of disodium 2,2'-dithiobis(alkylsulphonates), and in particular disodium 2,2'-dithiobis(ethanesulphate) (dimesna). Said novel method is summarised by the reaction diagram (...
|
|
WO/2002/006189A2 |
The present invention relates to compounds of formula (I) and pharmaceutically acceptable salt and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associa...
|
|
WO/2002/006215A1 |
A compound which is an arylsulfonyl propanoic acid derivative of formula (I) : CH¿2?R¿1? XC(O)-C(OH)-SO¿2?-C¿6?H¿4?-N(R¿2?)COA (I) wherein X is HO-NH- or HO- , R1 is selected from -O-Ph, -S-Ph, -S-Het, -Hyd or -CH¿2?-Hyd, wherein ...
|
|
WO/2002/006211A1 |
A process for preparing 4-thioalkylbromobenzene derivatives of the formula I, (I), where: R?1¿ is C¿1?-C¿6?-alkyl, C¿1?-C¿6?-haloalkyl, C¿1?-C¿6?-alkoxy, C¿1?-C¿6?-haloalkoxy, C¿3?-C¿8?-cycloalkyl, halogen; R?2¿ is C¿1?-C¿6...
|
