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WO/2002/092068A1 |
Compounds represented by the following general formula (I), prodrugs thereof, salts thereof and drugs containing the same as the active ingredient: (I) wherein each symbol has the meaning as defined in the specification. Because of havin...
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WO/2002/089579A1 |
The present invention relates to use of malononitrile compounds of formula (X): wherein R¿1? and R¿2? are the same or different and independently C?1¿-C?5¿ (halo)alkyl, C?1¿-C?5¿ (halo)alkyloxy, C?2¿-C?5¿ (halo)alkenyl, C?2¿-C?5...
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WO/2002/090332A2 |
There are provided novel compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, T, U, X, Y, V and W are as defined in the specification, and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof; together wit...
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WO/2002/089739A2 |
This invention provides a method for inhibiting the growth of a microorganism that expresses Peptide Deformylase by contacting themicroorganism with an effective amount of the compound described herein. This method inhibits the growth of...
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WO/2002/090320A2 |
The present invention relates to malononitrile compounds of formula (Y): wherein R¿1? and R¿2? are the same or different and independently C¿1?-C¿5? (halo)-alkyl, C¿1?-C¿6? (halo)alkyloxy, (C¿2?-C¿5? (halo)alkenyl, C¿2?-C¿5? (h...
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WO/2002/090314A1 |
Certain known and novel pyruvate derivatives are particularly active in restoring or preserving metabolic integrity in oxidatively competent cells that have been subjected to oxygen deprivation. These pyruvate-derived compounds include, ...
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WO/2002/090321A1 |
The present invention relates to malononitrile compounds of formula (Y):wherein R¿1? and R¿2? are the same or different and independently C?1¿-C?5¿ (halo)alkyl, C?1¿-C?5¿ (halo)alkyloxy, C?2¿-C?5¿ (halo)alkenyl, C?2¿-C?5¿ (halo...
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WO/2002/088061A1 |
A novel compound which is highly effective in ameliorating the cellular disorders caused by radicals and in inhibiting the neurotoxicity induced by excitatory neurotransmitters such as glutamic acid. It is a compound represented by the f...
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WO/2002/088074A1 |
Phthalamide derivatives represented by the general formula (I)&semi insecticides for agricultural and horticultural use, containing the derivatives as the active ingredient&semi and a method for application thereof: (I) wherein R1, R2 an...
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WO/2002/088075A1 |
Phthalamide derivatives represented by the general formula (I)&semi insecticides for agricultural and horticultural use, containing the derivatives as the active ingredient&semi and a method for application thereof: (I) wherein R1, R2 an...
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WO/2002/089229A2 |
A molecular system (30) is provided for electric field activated switches, such as a crossed-wire device (10) or a pair of electrodes (12, 14) to which the molecular system (30) is linked by linking moieties. The cross-wire device (10) c...
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WO/2002/085838A1 |
The present invention relaters to copper-catalyzed carbon-heteroatom and carbon-carbon bond-forming methods. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the ...
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WO2001058855A9 |
Substituted phenylalanines are provided comprising an hydantoin, urea or 2-hydroxyl, 2-methylpropionyl group, dimers thereof and alkyl, polyfluoroamido and haloarylamino derivatives thereof, as well as radiolabeled derivatives thereof. T...
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WO/2002/083632A1 |
The invention concerns more particularly dodecylthio-phenylacetanilide derivative complexes such as (S)-2',3',5'-trimethyl-4'-hydroxy-$g(a)-dodecylthio-phenylac
etanilide or related derivatives thereof and cyclodextrins.
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WO/2002/083716A2 |
The invention relates to novel compounds of general formula (I), with inhibitory properties for the type B botulism toxin activity, the methods for preparation thereof and corresponding pharmaceutical compositions. The invention further ...
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WO/2002/083620A1 |
The first aspect of the present invention relates to a photo-activated pro-accord conjugate having the formula (I), wherein [PHOTO] is a photo-labile unit which upon exposure to electromagnetic radiation is capable of releasing a pro-acc...
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WO/2002/081424A2 |
The invention concerns beta 3-adrenergic agonists of general formula (I) wherein R1=R2 represents a methyl, ethyl, propyl, butyl, pentyl, hexyl group, their position isomers, their cyclic structures, a phenyl function halogenated or not,...
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WO/2002/081454A1 |
The present invention relates to novel hypolipidemic, antihyperglycemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceut...
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WO/2002/081464A1 |
The invention concerns 3-arylthio-propyl-amino-3,4-dihydro-2H-1,5-aryloxathiepin derivatives of general formula (I), wherein: R�1? and R�2?, identical or different, represent a hydrogen atom, a fluorine atom or a chlorine atom, a hyd...
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WO/2002/081432A2 |
Polymers grafted with a compount of formula I, formula (I) wherein the general symbols are as defined in claim 1, have outstanding stability against oxidative, thermal, dynamic, light-induced and/or ozone-induced degradation.
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WO/2002/079122A2 |
This invention relates to the method of placing a sulfone or sulfonamide group ortho to a phenol in a drug substance in order to increase the metabolic stability and the half-life of the compound, while maintaining the acidity of the phe...
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WO/2002/079143A1 |
The invention relates to compounds of formula (I) for treating for example sexual dysfunction, wherein R?1¿ is optionally substituted C¿1-6?alkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, hydrogen, C¿1-...
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WO/2002/078693A2 |
The present invention provides compounds of formula (I), which are antagonists of the 5-HT¿6? receptor.
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WO/2002/076925A2 |
The present invention discloses novel substituted aryl alkylamine compounds of Formula (I) or pharmaceutically acceptable salts thereofwhich have selective histamine-H3 receptor antagonist activity as well as methods for preparing such c...
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WO/2002/076962A1 |
A process for producing a 3-oxo-2-(2-thiazolyl)propanenitrile useful as an intermediate for agricultural chemicals, medicines, etc., especially as an intermediate for an acrylonitrile derivative which is an active ingredient for insectic...
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WO/2002/076939A2 |
Compounds having quinone and quinone analogs useful for pharmaceutical preparations have now been found which inhibit cysteine proteases, in particular, caspases and 3C-cysteine proteases. The cysteine protease inhibitors of the present ...
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WO/2002/076935A1 |
A novel a-lipoic acid derivative represented by the following formula (I). It has tyrosinase inhibitory activity, melanin production inhibitory activity, and elastase inhibitory activity. (I) (In the formula, M represents a metal and A r...
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WO/2002/076395A2 |
Agents and methods for chemoprevention and treatment of neoplasia are described, the agents including a selective inhibitor of inducible nitric oxide synthase and a combination of a selective inhibitor of inducible nitric oxide synthase ...
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WO/2002/074736A1 |
The present invention relates to a novel diaminedithiol derivative or a pharmaceutically acceptable salt thereof; radiorhenium or radiotechneticum complex thereof; a composition for treating liver cancer comprising the radiorhenium compl...
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WO/2002/074298A1 |
IL-6 production inhibitors containing as the active ingredient hydroxamic acid derivatives represented by the following general formula (I) or equivalents thereto, non-toxic salts thereof or prodrugs of the same, (I) wherein each symbol ...
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WO/2002/074296A1 |
Preventives and/or remedies for solid cancer which contain as the active ingredient hydroxamic acid derivatives represented by the following general formula (I): wherein each symbol is as defined in the description; non-toxic salts there...
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WO/2002/072559A1 |
This invention relates to a process for the manufacture of compounds which are useful to make either pesticides that can be used as fungicides, herbicides, insecticides, rodenticides or biocides, or pharmaceutical compounds for both huma...
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WO/2002/072536A1 |
The invention relates to novel compounds having Vanilloid Receptor (VR1) antagonist activity, processes for their preparation, to compositions containing them and to their use in the treatment of various disorders.
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WO/2002/072540A2 |
The present invention pertains to methods for preparing a compound of Formula (I), wherein A is O or N-L; each L is independently H or an acyl group; K is, together with the two contiguous linking carbon atoms, a phenyl ring, a 5- or 6-m...
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WO/2002/072007A2 |
Facially amphiphilic polyphenylene and heteroarylene polymers and articles made therform having biocidal surfaces are disclosed. The polymers can inhibit the growth of microorganisms in contact with the surface or in areas adjacent to sa...
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WO/2002/069901A2 |
This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bo...
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WO/2002/070469A2 |
Selective PDE3B inhibitors, including compounds of the general structural formula (I), and use of the selective PDE3B inhibitors and salts and solvates thereof as therapeutic agents, are disclosed.
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WO/2002/069909A2 |
This invention encompasses a process for making a compound of Formula A AThese compounds are intermediates useful in the preparation of certain non-steroidal anti-inflammatory agents.
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WO/2002/070462A1 |
The invention relates to compounds of formula (I), to salts and stereoisomers thereof, to their production and to their use for producing medicaments used for treating cardiovascular diseases.
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WO/2002/068367A1 |
The present invention generally relates to methods of inhibiting ethylene responses in plants and plant materials, and particularly relates to methods of inhibiting various ethylene responses including plant maturation and degradation, b...
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WO/2002/068393A1 |
Phenylalanine enamide derivatives of formula (1) are described: wherein R?1¿, R?X¿, R?Y¿, R?Z¿, X and V are as defined in claim 1. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prop...
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WO/2002/068383A2 |
The present invention relates to biscarbodiimides, thiourea derivatives, urea derivatives, and cross-linked hyaluronan derivatives having at least one intramolecular disulfide bond, and methods of preparation thereof. The invention also ...
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WO2000066104A9 |
ACE-2 inhibiting compounds are disclosed. Methods of using the compounds and pharmaceutical compositions containing the compounds are also claimed.
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WO1999064055A9 |
Disclosed are multibinding compounds which are agonists, partial agonists, inverse agonists or antagonists of the 5HT4 receptors, which are involved in gastrointestinal disorders. The multibinding compounds of this invention containing f...
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WO/2002/064551A1 |
A compound selected from the group consisting of a compound of formula I or formula II: (I) (II) wherein n is 3 or 4 wherein Cx is selected from the group consisting of -COOM, COOR¿6?, -CHO, -CH¿2?OR¿7?, -CH¿2?OCOR¿8?, -CONHR¿9? an...
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WO/2002/064553A1 |
A process for preparation of halogenoalcohol derivatives represented by the general formula (1) and novel useful intermediates are provided. Halogenoalcohols of the general formula (1), i.e., (2S,3R)-N-Cbz-3-amino-1-halogeno-4-phenylsulf...
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WO/2002/064545A1 |
The present invention relates to acylated indanyl amines according to the general formula (I) where R?1¿-R?4¿ have the meanings given in the description, A is CH¿2? CHOH or CH-(C¿1?-C¿3?-alkyl), B is CH¿2? or CH-(C¿1?-C¿3?-alkyl)...
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WO/2002/064549A1 |
PPAR alpha activators, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certan plasma lipid levels, including high density liporprotein-cholesterol and to lower certain other plasma lipid lev...
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WO/2002/064130A1 |
PPAR alpha activators, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipo-protein-cholesterol and to lower certain plasma lipid levels, ...
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WO/2002/062307A1 |
The invention relates to colouring agents for keratin fibres containing [1.1'-biphenyl]-2.4-diamine derivatives of general formula (I) or physiologically acceptable, water soluble salts thereof in addition to novel [1.1'-biphenyl]-2.4-di...
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