Title:
【発明の名称】適合性組織適合遺伝子を有する霊長類の胚幹細胞
Document Type and Number:
Japanese Patent JP2002523084
Kind Code:
A
Abstract:
Disclosed herein are methods for producing primate embryonic stem cells that are MHC-matched to a specific donor individual. In one aspect, one transplants donor primate cell nucleus to an enucleated primate oocyte. The culture of the resulting nuclear transfer product to the blastocyst stage and the subsequent isolation of primate ES cells from the inner cell mass is designed to allow the production of ES cells that are genetically identical for all nuclear genes to the original donor of the nucleus. Differentiated cells derived from the primate ES cells are less likely to be rejected by the donor's immune system when used for therapeutic purposes such as transplantation.
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Inventors:
Thomson James A
Application Number:
JP2000567669A
Publication Date:
July 30, 2002
Filing Date:
May 05, 1999
Export Citation:
Assignee:
Wisconsin Alumni Research Foundation
International Classes:
A61K35/48; A61P1/16; A61P3/10; A61P9/00; A61P17/02; A61P19/04; A61P25/14; A61P25/16; A61P25/28; A61P35/00; C12N5/0735; C12N15/09; C12N5/10; A61K35/12; (IPC1-7): C12N15/09; A61K35/48; A61P1/16; A61P3/10; A61P9/00; A61P17/02; A61P19/04; A61P25/14; A61P25/16; A61P25/28; A61P35/00; C12N5/10
Attorney, Agent or Firm:
Minoru Nakamura (9 outside)