Title:
【発明の名称】複数荷電変種を有する化学修飾酵素
Document Type and Number:
Japanese Patent JP2002533087
Kind Code:
A
Abstract:
This invention provides modified enzymes comprising one or more amino acid residues replaced by cysteine residues, where the cysteine residues are modified by replacing the thiol hydrogen in the cysteine residues with a substituent group providing a thiol side chain comprising a multiply charged moiety. The enzymes show improved interaction and/or specificity and/or activity with charged substrates.
Inventors:
Davis, Benjamin Gee.
Jones, John Brian
Bot, Richard Earl.
Jones, John Brian
Bot, Richard Earl.
Application Number:
JP2000589712A
Publication Date:
October 08, 2002
Filing Date:
December 20, 1999
Export Citation:
Assignee:
Genenker International, Inc.
International Classes:
G01N33/483; C11D3/386; C12N9/50; C12N9/54; C12N9/64; C12N15/55; C12Q1/34; C12R1/07; (IPC1-7): C12N9/54; C11D3/386; C12Q1/34; G01N33/483
Foreign References:
| WO1998023732A2 | 1998-06-04 |
Attorney, Agent or Firm:
Takashi Ishida (4 others)