Title:
新規アッセイ
Document Type and Number:
Japanese Patent JP2004520041
Kind Code:
A
Abstract:
A method of identifying a modulator Nogo function, the method comprising: (i) providing (a) a BACE polypeptide; (b) a Nogo polypeptide; (c) a test agent under conditions that would permit binding of a BACE polypeptide (a) to a Nogo polypeptide (b) in the absence of the test agent (c) wherein said BACE polypeptide (a) is BACE or a variant thereof or a fragment of either thereof capable of binding Nogo; and polypeptide (b) is Nogo or a variant thereof or a fragment of either thereof capable of binding BACE; (ii) monitoring Nogo mediated activity; and (iii) determining thereby whether the test agent is a modulator of Nogo activity. Modulators identified by a method of the invention and use of such modulators in the manufacture of a medicament for the treatment of disorders responsive to the modulation of Nogo activity such as acute neuronal injury.
Inventors:
Blackstock, walter, philip
Hale, Richard, Stephen
Prince, rabinder
Raleigh, Adele
Hale, Richard, Stephen
Prince, rabinder
Raleigh, Adele
Application Number:
JP2002558535A
Publication Date:
July 08, 2004
Filing Date:
January 18, 2002
Export Citation:
Assignee:
GLAXO GROUP LIMITED
SmithKline Beecham p.l.c.
SmithKline Beecham p.l.c.
International Classes:
G01N33/50; A61P25/00; A61P35/00; C12N15/09; C12Q1/37; G01N33/15; G01N33/68; (IPC1-7): C12Q1/37; G01N33/15; G01N33/50
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Ishii Teiji
Satoshi Fujita
Ishii Teiji