Title:
グリコーゲン合成酵素キナーゼ3ベータ阻害剤としてのアミド誘導体
Document Type and Number:
Japanese Patent JP2005507419
Kind Code:
A
Abstract:
This invention concerns a compound of formula a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein ring A represents a 6-membered heterocycle; R1 is hydrogen; aryl; formyl; C1-6alkylcarbonyl; optionally substituted C1-6alkyl; C1-6alkyloxycarbonyl; optionally substituted C1-6alkyloxyC1-6alkylcarbonyl; X is a direct bond or a linker atom or group; Z is O or S; R2 is hydrogen, C1-10alkyl, C2-10alkenyl, C2-10alkynyl, a carbocycle or a heterocycle, each of said groups may optionally be substituted; R3 is hydrogen; hydroxy; halo; optionally substituted C1-6alkyl or C2-6alkenyl or C2-6alkynyl; C1-6alkyloxy; C1-6alkylthio; C1-6alkyloxycarbonyl; C1-6alkylcarbonyloxy; carboxyl; cyano; nitro; amino; mono- or di(C1-6alkyl)amino; polyhaloC1-6alkyl; polyhaloC1-6alkyloxy; polyhaloC1-6alkylthio; R21; R21-C1-6alkyl; R21-O-; R21-S-; R21-C(-O)-; R21-S(-O)p-; R7-S(-O)p-; R7-S(-O)p-NH-; R21-S(-O)p-NH-; R7-C(-O)-; -NHC(-O)H; -C(-O)NHNH2; R7-C(-O)-NH-; R21-C(-O)-NH-; -C(-NH)R7; -C(-NH)R21; R4a or R4b each independently represent hydrogen, R8, -Y1-NR9-Y2-NR10R11, -Y1-NR9-Y1-R8, -Y1-NR9R10; provided that -X-R2 and/or R3 is other than hydrogen; their use, pharmaceutical compositions comprising them and processes for their preparation.
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Inventors:
Freinu, Eddie Jean Edgar
Vuinster, Peter Jacobs Johannes Antonius
Willem, Marc
Emblehs, Berner Constant Johann
Lachlan, Jijan Fernand Armand
Janssen, Paul Adrien Yang
Levi, Paulus Johannes
Jerez, Yang
De Jong, Marc Rene
Coymans, Lucien Maria Henrix
Freyderk Franc Desire
Kukula, Michael Joseph
Gates, Huygo Alphons Gabriel
Roni Maria, Nuiden
Marken, Marc Huber
Ludovic, Donald William
Vuinster, Peter Jacobs Johannes Antonius
Willem, Marc
Emblehs, Berner Constant Johann
Lachlan, Jijan Fernand Armand
Janssen, Paul Adrien Yang
Levi, Paulus Johannes
Jerez, Yang
De Jong, Marc Rene
Coymans, Lucien Maria Henrix
Freyderk Franc Desire
Kukula, Michael Joseph
Gates, Huygo Alphons Gabriel
Roni Maria, Nuiden
Marken, Marc Huber
Ludovic, Donald William
Application Number:
JP2003540151A
Publication Date:
March 17, 2005
Filing Date:
October 29, 2002
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NAAMLOZE VENNOOTSCHAP
International Classes:
A61K31/44; A61K31/4409; A61K31/505; A61K31/506; A61K31/5377; A61P3/10; A61P7/00; A61P17/00; A61P21/04; A61P25/00; A61P25/04; A61P25/16; A61P25/18; A61P25/24; A61P25/28; A61P29/00; A61P35/00; A61P43/00; C07D213/81; C07D213/82; C07D239/42; C07D401/12; C07D403/12; C07D403/14; C07D405/12; C07D407/12; C07D413/12; C07D413/14; C07D417/12; (IPC1-7): C07D213/82; A61K31/44; A61K31/4409; A61K31/505; A61K31/506; A61K31/5377; A61P3/10; A61P7/00; A61P17/00; A61P21/04; A61P25/00; A61P25/04; A61P25/16; A61P25/18; A61P25/24; A61P25/28; A61P29/00; A61P35/00; A61P43/00; C07D213/81; C07D239/42; C07D401/12; C07D403/12; C07D403/14; C07D413/12; C07D417/12
Attorney, Agent or Firm:
Heikichi Odashima
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