Title:
徐放型生物分解性微小球およびその製造方法
Document Type and Number:
Japanese Patent JP2005509611
Kind Code:
A
Abstract:
The invention concerns a method for preparing a pharmaceutical composition in the form of microspheres with prolonged release of a water-soluble active principle. The invention is characterized in that it comprises the following successive steps: dissolving an active principle in an appropriate amount of water; emulsifying the resulting aqueous solution of active principle with a d,l-lactide-co-glycolide matrix copolymer, of average molecular weight ranging between 40000 and 80000, dissolved in a chlorinated hydrocarbon, resulting in a first microfine and homogeneous emulsion; emulsifying said resulting first emulsion in an external aqueous phase, containing a surfactant, a viscosity-enhancing agent and an osmotic agent; extraction-evaporation of the solvent to obtain microspheres which are recuperated after filtering, washing and drying. The invention also concerns microspheres obtainable by implementing said method, having continuous release over a period of more than two months, advantageously over a period of at least three months.
Inventors:
Eularia, Ferret
Miguel, Angel, Ashin
Jesus, Garcia
Pele, Tallinn
Rosa, Arora
Montserrat, Lutojan
Amadeo, Perez
Miguel, Angel, Ashin
Jesus, Garcia
Pele, Tallinn
Rosa, Arora
Montserrat, Lutojan
Amadeo, Perez
Application Number:
JP2003533903A
Publication Date:
April 14, 2005
Filing Date:
October 10, 2002
Export Citation:
Assignee:
Pierre, Fabre, Medicaman
International Classes:
A61K47/34; A61K9/10; A61K9/16; A61K9/52; A61K38/00; A61K45/00; (IPC1-7): A61K47/34; A61K9/10; A61K9/52; A61K38/00; A61K45/00
Domestic Patent References:
| JPH09512002A | 1997-12-02 | |||
| JPH11501027A | 1999-01-26 | |||
| JPH11279054A | 1999-10-12 | |||
| JP2001522812A | 2001-11-20 | |||
| JPH0672863A | 1994-03-15 | |||
| JPH08259460A | 1996-10-08 |
Foreign References:
| WO1999024061A1 | 1999-05-20 |
Attorney, Agent or Firm:
Kenji Yoshitake
Yukitaka Nakamura
Konno Akio
Noritaka Yokota
Yukitaka Nakamura
Konno Akio
Noritaka Yokota