Title:
置換プリンの合成方法
Document Type and Number:
Japanese Patent JP2005509612
Kind Code:
A
Abstract:
The invention provides general methods for preparing 2,9-, 2,6,9-, O6-aryl- and O6-alkyl-substituted purines in a combinatorial and traceless fashion. The methods involve, in some embodiments, Mitsunobu alkylation of 2-fluoro-6-phenylsulfenylpurine at N9 with alcohols in solution, followed by C2-capture of the purine core with a resin-bound amine and subsequent oxidation and displacement of the C6 sulfonyl group with amines and anilines.
Inventors:
Din, Shen
Din, Kuang
Gray, Nasana Elle S.
Schultz, Peter G.
Din, Kuang
Gray, Nasana Elle S.
Schultz, Peter G.
Application Number:
JP2003534389A
Publication Date:
April 14, 2005
Filing Date:
October 12, 2002
Export Citation:
Assignee:
IR M LLC
The Script Research Institute
The Script Research Institute
International Classes:
C07D473/06; A61K31/52; A61K31/522; A61K31/5355; A61P9/00; A61P25/00; A61P29/00; A61P35/00; A61P43/00; C07D473/16; C07D473/18; C07D473/40; C07D519/00; (IPC1-7): C07D473/06; A61P9/00; A61P25/00; A61P29/00; A61P35/00; A61P43/00; C07D473/16; C07D473/18; C07D473/40; C07D519/00
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita