Title:
ロイシンベースモチーフおよびクロストリジウム神経毒
Document Type and Number:
Japanese Patent JP2005517627
Kind Code:
A
Abstract:
The present invention is directed to a modified neurotoxin which comprises a first region comprising a targeting moiety, a second region effective to translocate a modified neurotoxin across an endosome membrane and a third region effective to inhibit exocytosis wherein the third region comprises at least one additional leucine-based motif and wherein the additional leucine-based motif increases biological persistence.
Inventors:
Lance E Steward
Esther Fernandez-Salas
Todd M. Herrington
Kay Roger Aoki
Esther Fernandez-Salas
Todd M. Herrington
Kay Roger Aoki
Application Number:
JP2002514172A
Publication Date:
June 16, 2005
Filing Date:
July 20, 2001
Export Citation:
Assignee:
ALLERGAN,INCORPORATED
International Classes:
C12N15/09; A61K38/00; A61P1/00; A61P5/00; A61P21/00; A61P25/00; A61P25/04; A61P27/02; A61P29/02; A61P37/00; C07K14/33; (IPC1-7): C07K14/33; A61K38/00; A61P1/00; A61P5/00; A61P21/00; A61P25/00; A61P25/04; A61P27/02
Other References:
JPN6010057394, Ｊ． Ｂｉｏｌ． Ｃｈｅｍ．, 1992, ｖｏｌ．２６７， ｎｏ．２１, ｐｐ．１４７２１−１４７２９
JPN6010057396, Ｂｉｏｃｈｅｍｉｓｔｒｙ, 1995, ｖｏｌ．３４， ｎｏ．４６, ｐｐ．１５１７５−１５１８１
JPN6010057398, ＦＥＢＳ Ｌｅｔｔ．, 1999, ｖｏｌ．４５６， ｎｏ．１, ｐｐ．１３７−１４２
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JPN6010057398, ＦＥＢＳ Ｌｅｔｔ．, 1999, ｖｏｌ．４５６， ｎｏ．１, ｐｐ．１３７−１４２
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Attorney, Agent or Firm:
Aoyama Aoi
Osamu Kawamiya
Yasuo Shibata
Osamu Kawamiya
Yasuo Shibata