Title:
アリール置換ヒダントイン化合物及びナトリウムチャネルブロッカーとしてのその使用
Document Type and Number:
Japanese Patent JP2005538101
Kind Code:
A
Abstract:
This invention relates to aryl substituted hydantoins of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein n, A, A', R, R1 and R2, are defined in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
Inventors:
Sun, Kun
Kyle, Donald, Jay.
Kyle, Donald, Jay.
Application Number:
JP2004524207A
Publication Date:
December 15, 2005
Filing Date:
July 31, 2003
Export Citation:
Assignee:
Euro-Certique S.A.
International Classes:
A61K31/445; A61K31/454; A61P21/00; A61P23/02; A61P25/00; A61P25/02; A61P25/04; A61P25/08; A61P25/18; A61P25/24; A61P25/28; A61P27/16; A61P43/00; C07D233/72; C07D233/74; C07D233/84; C07D233/86; (IPC1-7): C07D233/74; A61K31/454; A61P21/00; A61P23/02; A61P25/00; A61P25/02; A61P25/04; A61P25/08; A61P25/18; A61P25/24; A61P25/28; A61P27/16; A61P43/00
Attorney, Agent or Firm:
Hiroshi Kobayashi
Eiji Katayama
Junko Kobayashi
Norio Omori
Eiji Katayama
Junko Kobayashi
Norio Omori