Title:
細胞付着のためリガンドを同定する高スループット法
Document Type and Number:
Japanese Patent JP2007505623
Kind Code:
A
Abstract:
A high throughput method is provided for identifying agents capable of producing a desired biological response in whole cells. The method includes the steps of providing receptacles having a culture surface; placing different mixtures of single agents into selective ones of the receptacles according to a statistical design; and immobilizing the mixtures of single agents to the culture surface. The method further includes contacting the immobilized agents with the whole cells; and acquiring data which is indicative of a desired biological response in the contacted cells. The method also includes using statistical modeling of the acquired data to determine which mixtures of single agents and/or which single agents in these mixtures are effective in producing the desired biological response in the contacted cells.
Inventors:
Andrea Reeveman-Vinson
Jonathan A. Raleigh
Chris H. Bodley
Mohammed A. Heydaran
Jonathan A. Raleigh
Chris H. Bodley
Mohammed A. Heydaran
Application Number:
JP2006526947A
Publication Date:
March 15, 2007
Filing Date:
September 10, 2004
Export Citation:
Assignee:
BECTON, DICKINSON AND COMPANY
International Classes:
C12Q1/02; G01N33/50; G01N33/543
Attorney, Agent or Firm:
Yoshikazu Tani
Kazuo Abe
Kazuo Abe