Title:
アレルギー性鼻炎および喘息のためのRNAiベースの治療
Document Type and Number:
Japanese Patent JP2007527240
Kind Code:
A
Abstract:
The present invention provides compositions comprising one or more RNAi agents (e.g., siRNAs, shRNAs, or RNAi vectors) for the treatment of conditions and diseases mediated by (e.g., featuring IgE-mediated hypersensitivity), as well as systems for identifying RNAi agents effective for this purpose. The compositions are suitable for the treatment of allergic rhinitis and/or asthma. In certain embodiments of the invention the RNAi agent is targeted to a transcript that encodes a protein selected from the group consisting of the FCεRIα chain, the FCεRIβ chain, c-Kit, Lyn, Syk, ICOS, OX40L, CD40, CD80, CD86, Re1A, Re1B, 4-1BB ligand, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, CD83, SLAM, common γ chain, and COX-2. In addition, the invention provides RNAi agent/delivery agent compositions and methods of use. In certain embodiments of the invention compositions comprising an RNAi agent are delivered by the respiratory route.
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Inventors:
Chen, Jan Zoo
Asen, Herman N.
Gee, Kin
Asen, Herman N.
Gee, Kin
Application Number:
JP2007501881A
Publication Date:
September 27, 2007
Filing Date:
March 01, 2005
Export Citation:
Assignee:
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
International Classes:
C12N15/09; A61K9/12; A61K31/7105; A61K31/713; A61K47/32; A61K47/34; A61K47/36; A61K47/42; A61K48/00; A61P11/02; A61P11/06; A61P17/02; A61P29/00; A61P31/04; A61P37/08; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/11; C12N15/113; C12Q1/02; C12Q1/06; G01N33/15; G01N33/50
Domestic Patent References:
| JP2003524637A | 2003-08-19 |
Foreign References:
| WO2002081628A2 | 2002-10-17 | |||
| WO2003099298A1 | 2003-12-04 | |||
| US5892023A | 1999-04-06 |
Other References:
JPN6010057412, Ｊ． Ｂｉｏｌ． Ｃｈｅｍ．， ２００３， Ｖｏｌ．２７８， Ｎｏ．７， ｐ．４７２５−４７２９
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita