Title:
上皮細胞成長因子受容体遺伝子プロモーターにおける多型
Document Type and Number:
Japanese Patent JP2007527241
Kind Code:
A
Abstract:
The present invention concerns polymorphisms in the epidermal growth factor receptor (EGFR), gene. In some embodiments, the present invention is directed at compositions and methods involving single nucleotide polymorphisms (SNPs) in the promoter of the EGFR gene that affect EGFR expression. The identification of polymorphisms associated with EGFR expression or activity enables novel methods and compositions for evaluating the potential efficacy and toxicity of an EGFR-targeting therapeutic agent, predicting a patient's clinical prognosis, and evaluating a patient's risk of developing a disease that is associated with EGFR dysregulation.
Inventors:
Latein Mark Jay.
Lou Wankin
Innocenti Federico
Lou Wankin
Innocenti Federico
Application Number:
JP2007501893A
Publication Date:
September 27, 2007
Filing Date:
March 01, 2005
Export Citation:
Assignee:
University of Chicago
International Classes:
C12Q1/68; C12N15/09
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi