Title:
骨粗鬆症の治療薬を開発するための新規分子
Document Type and Number:
Japanese Patent JP2007534610
Kind Code:
A
Abstract:
This invention relates to a novel class of acidic amino acid/dicarboxylic acid derivatives (sulfonic acid/sulfate derivatives of naturally occurring amino acids and their amides) useful as inhibitors of osteoclastogenesis. The invention also provides methods of using the novel class of acidic amino acid/dicarboxylic acid derivatives of the general formula ZOC-(CRR)m-COOH, wherein: m=2, 3 or 4; Z is OH or NH2; one R in the compound is from the group consisting of SO3H, OSO3H, CH2-SO3H, CH2-OSO3H, and NHSO3H, and the remaining Rs are H or NH2, for inhibition of osteoclastogenesis.
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Inventors:
Lao Canary Venkatashuva
Wharney Mohan Ramachandra
Manivel Vane Catamy
Shrayan Paramez Waran Perunnina Class
Sin Vinod Kumar
Anand Rama Sammy Vijaya
Desser Erich
Mishra Gyan Chandler
Chatterjee Anil
Wharney Mohan Ramachandra
Manivel Vane Catamy
Shrayan Paramez Waran Perunnina Class
Sin Vinod Kumar
Anand Rama Sammy Vijaya
Desser Erich
Mishra Gyan Chandler
Chatterjee Anil
Application Number:
JP2005509587A
Publication Date:
November 29, 2007
Filing Date:
December 31, 2003
Export Citation:
Assignee:
Council of Scientific and Industrial Research
International Classes:
A61K31/198; A61K31/16; A61K31/185; A61K31/19; A61K31/194; A61K31/195; A61K31/255; A61P19/02; A61P19/08; A61P19/10; A61P43/00; C07C305/06; C07C307/02; C07C309/17; C07C309/18
Foreign References:
| WO2003043626A1 | 2003-05-30 |
Attorney, Agent or Firm:
Koichi Washida