チロシンキナーゼ阻害剤として適する環状ジアリールウレア

Title:

チロシンキナーゼ阻害剤として適する環状ジアリールウレア

Document Type and Number:

Japanese Patent JP2008514570

Kind Code:

A

Abstract:

The invention relates to novel compounds of Formula I: wherein p is 1, 2 or 3; n is 0, 1, 2 or 3; m is 0, 1, 2 or 3; A is CRc, S, NRc or O, where Rc is H or lower alkyl; X, Y and Z are each independently selected from N or C—R3, wherein at least two of X, Y and Z are N; and each Ra is independently selected from hydrogen and lower-alkyl; each Rb is hydrogen or lower-alkyl; G is a group Ar or represents CN or unsubstituted or substituted lower alkyl; Ar is a saturated or unsaturated cyclic group, which is substituted or unsubstituted and maybe a five or six membered monocyclic or a 8, 9, 10, 11 or 12 membered bicyclic or tricyclic ring and may contain 0, 1, 2 or 3 heteroatoms selected from O, N and S; and wherein the radicals have R1, R2, R3 and R4 have the meanings as defined herein, to salts, esters, N-oxides or prodrugs thereof; and their use in the treatment of protein kinase dependent diseases, their use in the manufacture of pharmaceutical compositions for use in the treatment of said diseases, methods of use of diary urea derivatives in the treatment of said diseases, pharmaceutical preparations comprising these novel diaryl urea derivatives, processes for the manufacture of the novel diaryl urea derivatives, the use or methods of use of the novel diaryl urea derivatives as mentioned above, and/or these novel diaryl urea derivatives for use in the treatment of the animal or human body.

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Inventors:

Guido Bolt
Giorgio Caravatti
Andreas Flair Sheimer
Pascal Fure
Paul W Manley
Carol Piso Soldeman
Andrea Faupel

Application Number:

JP2007532856A

Publication Date:

May 08, 2008

Filing Date:

September 27, 2005

Export Citation:

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Assignee:

NOVARTIS AG

International Classes:

C07D401/12; A61K31/506; A61K31/5377; A61K31/541; A61K31/55; A61K31/553; A61P35/00; A61P35/02; A61P43/00; C07D401/14; C07D403/12; C07D403/14; C07D405/14; C07D409/14; C07D413/14; C07D417/12; C07D417/14

Domestic Patent References:

JP2000505096A

2000-04-25

Foreign References:

WO2004043379A2	2004-05-27
WO2004020434A1	2004-03-11
WO2003099771A2	2003-12-04

Attorney, Agent or Firm:

Mitsuo Tanaka
Takuji Yamada
Mitsutaka Iwasaki
Aoyama Aoi

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