Title:
4-ヒドロキシイソロイシンの類似体及びその使用
Document Type and Number:
Japanese Patent JP2008530197
Kind Code:
A
Abstract:
The invention relates to analogs of 4-hydroxyisoleucine, and to lactones, pharmaceutically acceptable salts, and prodrugs thereof, to processes for their preparation, and to pharmaceutical compositions comprising the same. The analogs of the invention stimulate both glucose uptake and insulin secretion, and may thus be useful for the prevention and treatment of disorders of carbohydrate or lipid metabolism, including diabetes mellitus (type 1 and type 2 diabetes), pre-diabetes, and Metabolic Syndrome.
Inventors:
Charles Mioskowski, Charles
Delamo Marine, Sandra
Maruni, Martine
Jill, Manzinder
Delamo Marine, Sandra
Maruni, Martine
Jill, Manzinder
Application Number:
JP2007555730A
Publication Date:
August 07, 2008
Filing Date:
February 17, 2006
Export Citation:
Assignee:
Inodia ink.
Centre National Dura Recherche Scientific (S.N.A.L.S.)
Universite Louis Pasture Strasbourg
Centre National Dura Recherche Scientific (S.N.A.L.S.)
Universite Louis Pasture Strasbourg
International Classes:
C07C229/22; A61K31/198; A61K31/27; A61K31/365; A61K31/40; A61K31/401; A61K31/4025; A61K31/445; A61K31/5355; A61P3/06; A61P3/08; A61P3/10; A61P43/00; C07C229/28; C07C229/36; C07D207/16; C07D211/60; C07D265/06; C07D295/18; C07D307/33; C07D405/06
Domestic Patent References:
| JPH06157302A | 1994-06-03 | |||
| JP2008500955A | 2008-01-17 |
Attorney, Agent or Firm:
Mieko Kashihara