Title:
4-ヒドロキシイソロイシンのジアステレオ異性体及びこれらの使用
Document Type and Number:
Japanese Patent JP2008530198
Kind Code:
A
Abstract:
The invention relates to configurational isomers 4-hydroxyisoleucine, and to lactones, pharmaceutically acceptable salts, and prodrugs thereof, to processes for their preparation, and to pharmaceutical compositions comprising the same. The isomers of the invention exhibit insulinotropic activity and thus may be useful for the prevention and treatment of disorders of carbohydrate or lipid metabolism, including diabetes mellitus (type 1 and type 2 diabetes), pre-diabetes, and Metabolic Syndrome.
Inventors:
Cocle, Claude
Charles Mioskowski, Charles
Wagner, Alan
Charles Mioskowski, Charles
Wagner, Alan
Application Number:
JP2007555732A
Publication Date:
August 07, 2008
Filing Date:
February 17, 2006
Export Citation:
Assignee:
Inodia ink.
Centre National Dura Recherche Scientific (S.N.A.L.S.)
Universite Louis Pasture Strasbourg
Centre National Dura Recherche Scientific (S.N.A.L.S.)
Universite Louis Pasture Strasbourg
International Classes:
C07C229/22; A61K31/198; A61K31/365; A61K45/00; A61P3/00; A61P3/10; C07D307/33
Attorney, Agent or Firm:
Mieko Kashihara