Title:
開始メチオニン残基が除去された免疫グロブリンFc領域の大量生産方法
Document Type and Number:
Japanese Patent JP2009513110
Kind Code:
A
Abstract:
Disclosed is a method for the mass production of a monomeric or dimeric immunoglobulin Fc region, free of initial methionine residues, using a recombinant expression vector comprising a nucleotide sequence coding for a recombinant immunoglobulin Fc region comprising an immunoglobulin Fc region linked at the N-terminus thereof to an immunoglobulin Fc region via a peptide bond.
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Inventors:
Jun Seung Yob
Kim Jin Seung
Shinhuang Fan
Kwongse Chan
Lee Wang Soon
Song Dai High
Kim Jin Seung
Shinhuang Fan
Kwongse Chan
Lee Wang Soon
Song Dai High
Application Number:
JP2008526876A
Publication Date:
April 02, 2009
Filing Date:
August 16, 2006
Export Citation:
Assignee:
HANMI PHARMACEUTICAL CO., LTD.
International Classes:
C12P21/02; A61K39/395; A61P43/00; C07K16/00; C12N15/09
Domestic Patent References:
| JPS63290899A | 1988-11-28 | |||
| JP2003508075A | 2003-03-04 | |||
| JP2003512011A | 2003-04-02 | |||
| JPH03285684A | 1991-12-16 | |||
| JPH089979A | 1996-01-16 | |||
| JPH03130088A | 1991-06-03 |
Foreign References:
| WO2005047335A1 | 2005-05-26 | |||
| WO2005047336A1 | 2005-05-26 | |||
| WO2005047337A1 | 2005-05-26 | |||
| WO2005047334A1 | 2005-05-26 | |||
| US6660843B1 | 2003-12-09 | |||
| WO2005047336A1 | 2005-05-26 | |||
| WO2005059127A1 | 2005-06-30 |
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JPN6011049725; Ｐｒｏｔｅｉｎ Ｓｃｉ． Ｖｏｌ． １３, 2004, ｐ． １８０２-１８１０
JPN6011049722; Ｊ． Ｂｉｏｌ． Ｃｈｅｍ． Ｖｏｌ． ２７９， Ｎｏ． １５, 2004, ｐ． １５０５９-１５０６６
JPN6011049723; Ｊ． Ｂｉｏｌ． Ｃｈｅｍ． Ｖｏｌ． ２６８， Ｎｏ． １８, 1993, ｐ． １３１１８-１３１２７
JPN6011049724; Ｊ． Ｂａｃｔｅｒｉｏｌ． Ｖｏｌ． １６９， Ｎｏ． ２, 1987, ｐ． ７５１-７５７
JPN6012063554; Ｇｅｎｅ Ｖｏｌ． ６５, 1988, ｐ． １３-２２
JPN6011049725; Ｐｒｏｔｅｉｎ Ｓｃｉ． Ｖｏｌ． １３, 2004, ｐ． １８０２-１８１０
JPN6012063552; Ｊ． Ｂｉｏｌ． Ｃｈｅｍ． Ｖｏｌ． ２４５， Ｎｏ． １８, 1970, ｐ． ４７６０-４７６９
JPN6011049722; Ｊ． Ｂｉｏｌ． Ｃｈｅｍ． Ｖｏｌ． ２７９， Ｎｏ． １５, 2004, ｐ． １５０５９-１５０６６
JPN6011049723; Ｊ． Ｂｉｏｌ． Ｃｈｅｍ． Ｖｏｌ． ２６８， Ｎｏ． １８, 1993, ｐ． １３１１８-１３１２７
JPN6011049724; Ｊ． Ｂａｃｔｅｒｉｏｌ． Ｖｏｌ． １６９， Ｎｏ． ２, 1987, ｐ． ７５１-７５７
JPN6012063554; Ｇｅｎｅ Ｖｏｌ． ６５, 1988, ｐ． １３-２２
JPN6011049725; Ｐｒｏｔｅｉｎ Ｓｃｉ． Ｖｏｌ． １３, 2004, ｐ． １８０２-１８１０
JPN6012063552; Ｊ． Ｂｉｏｌ． Ｃｈｅｍ． Ｖｏｌ． ２４５， Ｎｏ． １８, 1970, ｐ． ４７６０-４７６９
Attorney, Agent or Firm:
Janggi Motonori