Title:
モザイク異数体幹細胞の選択、増殖及び使用
Document Type and Number:
Japanese Patent JP2009514552
Kind Code:
A
Abstract:
The distribution of cell karyotypes within a population of cells can determine the phenotype and ability of stem cells to differentiate into desired cell types, to function normally, as well as represent risk for adverse events like cancer. Therefore, determination of the aneuploid mosaic status of a cell population is useful in identifying and/or maintaining desirable traits and eliminating undesirable traits in stem cells, and for defining them at the level of their chromosomal complement.
Inventors:
Peterson, Suzanne Arlene
Yoon, Yoon Chi Yun
Ren, Stevens Castrup
Westra, Yuruyen Willem
Chiyun, Jeerold Jiyun Min
Yoon, Yoon Chi Yun
Ren, Stevens Castrup
Westra, Yuruyen Willem
Chiyun, Jeerold Jiyun Min
Application Number:
JP2008540214A
Publication Date:
April 09, 2009
Filing Date:
November 09, 2006
Export Citation:
Assignee:
The Scripts Research Institution
International Classes:
C12Q1/02
Foreign References:
| US20030124584A1 | 2003-07-03 | |||
| US20050019907A1 | 2005-01-27 |
Other References:
JPN5008018645; ＳＡＩＴＯＨ， Ｋ．: ＢＬＯＯＤ Ｖ９２ Ｎ８, 19981015, Ｐ２８８６-２８９２
JPN5008018655; ＫＩＮＧＳＢＵＲＹ， Ｍ．Ａ．: ＰＮＡＳ Ｖ１０２ Ｎ１７, 20050426, Ｐ６１４３-６１４７
JPN5008018654; ＲＥＨＥＮ， Ｓ．Ｋ．: 'Ｃｈｒｏｍｏｓｏｍａｌ ｖａｒｉａｔｉｏｎ ｉｎ ｎｅｕｒｏｎｓ ｏｆ ｔｈｅ ｄｅｖｅｌｏｐｉｎｇ ａｎｄ ａｄｕｌｔ ｍａｍｍａｌｉａｎ ｎｅｒｖｏｕｓ ｓｙｓｔｅｍ．' Ｐｒｏｃ．Ｎａｔｌ．Ａｃａｄ．Ｓｃｉ．ＵＳＡ Ｖ９８ Ｎ２３, 20011106, Ｐ１３３６１-１３３６６
JPN7012000965; Ｒｅｈｅｎ Ｓ．Ｋ． ｅｔ ａｌ．: 'Ｃｏｎｓｔｉｔｕｔｉｏｎａｌ Ａｎｅｕｐｌｏｉｄｙ ｉｎ ｔｈｅ Ｎｏｒｍａｌ Ｈｕｍａｎ Ｂｒａｉｎ．' Ｊｏｕｒｎａｌ ｏｆ Ｎｅｕｒｏｓｃｉｅｎｃｅ Ｖｏｌ．２５， Ｎｏ．９, 200503, ｐ．２１７６-２１８０
JPN5008018649; ＹＡＮＧ， Ａ．Ｈ． ｅｔ ａｌ．: 'Ｃｈｒｏｍｏｓｏｍｅ ｓｅｇｒｅｇａｔｉｏｎ ｄｅｆｅｃｔｓ ｃｏｔｒｉｂｕｔｅ ｔｏ ａｎｅｕｐｌｏｉｄｙ ｉｎ ｎｏｒｍａｌ ｎｅｕｒａｌ ｐｒｏｇｅｎｉｔｏｒ ｃｅｌｌｓ．' Ｊｏｕｒｎａｌ ｏｆ Ｎｅｕｒｏｓｃｉｅｎｃｅ Ｖｏｒ．２３， Ｎｏ．３２, 20031112, ｐ．１０４５４-１０４６２
JPN5008018655; ＫＩＮＧＳＢＵＲＹ， Ｍ．Ａ．: ＰＮＡＳ Ｖ１０２ Ｎ１７, 20050426, Ｐ６１４３-６１４７
JPN5008018654; ＲＥＨＥＮ， Ｓ．Ｋ．: 'Ｃｈｒｏｍｏｓｏｍａｌ ｖａｒｉａｔｉｏｎ ｉｎ ｎｅｕｒｏｎｓ ｏｆ ｔｈｅ ｄｅｖｅｌｏｐｉｎｇ ａｎｄ ａｄｕｌｔ ｍａｍｍａｌｉａｎ ｎｅｒｖｏｕｓ ｓｙｓｔｅｍ．' Ｐｒｏｃ．Ｎａｔｌ．Ａｃａｄ．Ｓｃｉ．ＵＳＡ Ｖ９８ Ｎ２３, 20011106, Ｐ１３３６１-１３３６６
JPN7012000965; Ｒｅｈｅｎ Ｓ．Ｋ． ｅｔ ａｌ．: 'Ｃｏｎｓｔｉｔｕｔｉｏｎａｌ Ａｎｅｕｐｌｏｉｄｙ ｉｎ ｔｈｅ Ｎｏｒｍａｌ Ｈｕｍａｎ Ｂｒａｉｎ．' Ｊｏｕｒｎａｌ ｏｆ Ｎｅｕｒｏｓｃｉｅｎｃｅ Ｖｏｌ．２５， Ｎｏ．９, 200503, ｐ．２１７６-２１８０
JPN5008018649; ＹＡＮＧ， Ａ．Ｈ． ｅｔ ａｌ．: 'Ｃｈｒｏｍｏｓｏｍｅ ｓｅｇｒｅｇａｔｉｏｎ ｄｅｆｅｃｔｓ ｃｏｔｒｉｂｕｔｅ ｔｏ ａｎｅｕｐｌｏｉｄｙ ｉｎ ｎｏｒｍａｌ ｎｅｕｒａｌ ｐｒｏｇｅｎｉｔｏｒ ｃｅｌｌｓ．' Ｊｏｕｒｎａｌ ｏｆ Ｎｅｕｒｏｓｃｉｅｎｃｅ Ｖｏｒ．２３， Ｎｏ．３２, 20031112, ｐ．１０４５４-１０４６２
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura