Title:
置換されている8-ピペリジニル-2-ピリジニル-ピリミド[1,2-a]ピリミジン-6-オンおよび8-ピペリジニル-2-ピリミジニル-ピリミド[1,2-a]ピリミジン-6-オン誘導体
Document Type and Number:
Japanese Patent JP2010509203
Kind Code:
A
Abstract:
The invention relates to a pyrimidone derivative represented by formula (I) or a salt thereof:
wherein:
X represents two hydrogen atoms, a sulfur atom, an oxygen atom or a C 1-2 alkyl group and a hydrogen atom;
Y represents a bond, a carbonyl group or a methylene group optionally substituted;
R1 represents a 2, 3 or 4-pyridine ring or a 2, 4 or 5-pyrimidine ring, the ring being optionally substituted;
R2 represents a benzene ring or a naphthalene ring; the rings being optionally substituted;
R3 represents a hydrogen atom, a C 1-6 alkyl group or a halogen atom;
R4 represents a hydrogen atom, a C 1-6 alkoxy carbonyl group or a C 1-6 alkyl group optionally substituted;
n represents 0 to 3; p represents 2; q represents 0; o represents 0, 1 or 2 and m represents respectively 4, 3 or 2, o+m being equal to 4. The invention relates also to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3², such as Alzheimer disease.
Inventors:
Rotido, alistair
Mura, Saturday
Slow-in skis, Frank
Yesilles
Mura, Saturday
Slow-in skis, Frank
Yesilles
Application Number:
JP2009535149A
Publication Date:
March 25, 2010
Filing Date:
November 06, 2007
Export Citation:
Assignee:
Sanofui-Aventice
Mitsubishi Tanabe Pharma Corporation
Mitsubishi Tanabe Pharma Corporation
International Classes:
C07D487/04; A61K31/519; A61P1/16; A61P3/04; A61P3/10; A61P7/00; A61P9/00; A61P17/02; A61P17/14; A61P19/08; A61P25/00; A61P25/02; A61P25/14; A61P25/16; A61P25/18; A61P25/24; A61P25/28; A61P27/02; A61P27/06; A61P33/06; A61P35/00; A61P35/02; A61P43/00
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura