Title:
統合失調症を治療するため及び薬物渇望を低減するためのシステイン及びシスチンプロドラッグ
Document Type and Number:
Japanese Patent JP2011514324
Kind Code:
A
Abstract:
The present invention discloses cysteine prodrugs having the general formula: cystine dimmers of the cysteine prodrugs having the general formula: protected cysteine analogs having the general formula: and dimmers of the protected cysteine analogs having the general formula: The invention further encompasses pharmaceutical compositions containing the disclosed prodrugs, dimmers, analogs, and methods of using such compounds for treatment of schizophrenia and drug addiction.
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Inventors:
Cook, James, M
Baker, David, A
Inn, Wen Yuan
Johnson, Edward, Marl, The Second
Baker, David, A
Inn, Wen Yuan
Johnson, Edward, Marl, The Second
Application Number:
JP2010546090A
Publication Date:
May 06, 2011
Filing Date:
February 09, 2009
Export Citation:
Assignee:
Market university
University of Wisconsin-Milwaukee Research Foundation
University of Wisconsin-Milwaukee Research Foundation
International Classes:
C07K5/062; A61K31/198; A61K31/223; A61K31/4965; A61K31/497; A61K31/4985; A61K38/00; A61P25/18; A61P25/30; A61P43/00; C07C321/14; C07D241/08; C07D487/04; C07K5/103; C07K5/12
Foreign References:
| WO2004030522A2 | 2004-04-15 |
Other References:
JPN6013057465; Ｂｕｌｌｅｔｉｎ ｏｆ ｔｈｅ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ ｏｆ Ｊａｐａｎ Ｖｏｌ．２９， Ｎｏ．１, 1956, ｐ．８５-８８
JPN6013057466; Ｂｕｌｌｅｔｉｎ ｄｅｓ Ｓｏｃｉｅｔｅｓ Ｃｈｉｍｉｑｕｅｓ Ｂｅｌｇｅｓ Ｖｏｌ．９０， Ｎｏ．８, 1981, ｐ．７８５-８０２
JPN6013057467; Ｃｏｌｌｅｃｔｉｏｎ ｏｆ Ｃｚｅｃｈｏｓｌｏｖａｋ Ｃｈｅｍｉｃａｌ Ｃｏｍｍｕｎｉｃａｔｉｏｎｓ Ｖｏｌ．３１, 1966, ｐ．４２９６-４３１１
JPN6013057464; Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｂｉｏｌｏｇｉｃａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．７０， Ｎｏ．２, 1926, ｐ．３８１-３９５
JPN6013057466; Ｂｕｌｌｅｔｉｎ ｄｅｓ Ｓｏｃｉｅｔｅｓ Ｃｈｉｍｉｑｕｅｓ Ｂｅｌｇｅｓ Ｖｏｌ．９０， Ｎｏ．８, 1981, ｐ．７８５-８０２
JPN6013057467; Ｃｏｌｌｅｃｔｉｏｎ ｏｆ Ｃｚｅｃｈｏｓｌｏｖａｋ Ｃｈｅｍｉｃａｌ Ｃｏｍｍｕｎｉｃａｔｉｏｎｓ Ｖｏｌ．３１, 1966, ｐ．４２９６-４３１１
JPN6013057465; Ｂｕｌｌｅｔｉｎ ｏｆ ｔｈｅ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ ｏｆ Ｊａｐａｎ Ｖｏｌ．２９， Ｎｏ．１, 1956, ｐ．８５-８８
JPN6014050162; Ｊｏｕｒｎａｌ ｏｆ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ Ｖｏｌ．８０， Ｎｏ．５, 1958, ｐ．１１５８-１１６４
JPN6013057466; Ｂｕｌｌｅｔｉｎ ｄｅｓ Ｓｏｃｉｅｔｅｓ Ｃｈｉｍｉｑｕｅｓ Ｂｅｌｇｅｓ Ｖｏｌ．９０， Ｎｏ．８, 1981, ｐ．７８５-８０２
JPN6013057467; Ｃｏｌｌｅｃｔｉｏｎ ｏｆ Ｃｚｅｃｈｏｓｌｏｖａｋ Ｃｈｅｍｉｃａｌ Ｃｏｍｍｕｎｉｃａｔｉｏｎｓ Ｖｏｌ．３１, 1966, ｐ．４２９６-４３１１
JPN6013057464; Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｂｉｏｌｏｇｉｃａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．７０， Ｎｏ．２, 1926, ｐ．３８１-３９５
JPN6013057466; Ｂｕｌｌｅｔｉｎ ｄｅｓ Ｓｏｃｉｅｔｅｓ Ｃｈｉｍｉｑｕｅｓ Ｂｅｌｇｅｓ Ｖｏｌ．９０， Ｎｏ．８, 1981, ｐ．７８５-８０２
JPN6013057467; Ｃｏｌｌｅｃｔｉｏｎ ｏｆ Ｃｚｅｃｈｏｓｌｏｖａｋ Ｃｈｅｍｉｃａｌ Ｃｏｍｍｕｎｉｃａｔｉｏｎｓ Ｖｏｌ．３１, 1966, ｐ．４２９６-４３１１
JPN6013057465; Ｂｕｌｌｅｔｉｎ ｏｆ ｔｈｅ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ ｏｆ Ｊａｐａｎ Ｖｏｌ．２９， Ｎｏ．１, 1956, ｐ．８５-８８
JPN6014050162; Ｊｏｕｒｎａｌ ｏｆ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ Ｖｏｌ．８０， Ｎｏ．５, 1958, ｐ．１１５８-１１６４
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Takao Kawasaki
Sadao Matsumura
Fumio Takino
Toshiaki Tsuda
Yuji Yoshida
Takao Kawasaki
Sadao Matsumura
Fumio Takino
Toshiaki Tsuda
Yuji Yoshida