Title:
炎症性疾患、自己免疫疾患及び循環器疾患におけるエオタキシン-2(CCL24)阻害剤
Document Type and Number:
Japanese Patent JP2012516150
Kind Code:
A
Abstract:
The presently described subject matter is based on the finding that inhibition of eotaxin-2 by polyclonal or monoclonal antibodies, has a significant protective effect in animal models of inflammatory diseases such as rheumatoid arthritis, experimental autoimmune encephalomyelitis (EAE), colitis, diabetes, and atherosclerosis. Thus, provided are pharmaceutical compositions including specific anti-eotaxin 2 antibodies for use alone or in combination with other therapeutic agents in the treatment of inflammatory, autoimmune and cardiovascular diseases. Also provided are specific anti-eotaxin-2 monoclonal antibodies, and methods of treatment utilizing such antibodies.
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Inventors:
George, Jacob
Keren, Gad
Keren, Gad
Application Number:
JP2011547057A
Publication Date:
July 19, 2012
Filing Date:
January 28, 2010
Export Citation:
Assignee:
The Medical Research, Infrastructure, and Health Services Fund of the Tel Aviv Medical Center
International Classes:
C12N15/09; A61K31/713; A61K39/395; A61K45/00; A61K48/00; A61P1/04; A61P3/10; A61P9/00; A61P9/10; A61P19/02; A61P25/00; A61P29/00; A61P37/02; C07K16/24; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/08
Domestic Patent References:
| JP2001524818A | 2001-12-04 | |||
| JP2007538003A | 2007-12-27 |
Foreign References:
| US0007019A | 1850-01-15 |
Other References:
JPN6014021202; Ｊｏｕｒｎａｌ ｏｆ Ａｌｌｅｒｇｙ ａｎｄ Ｃｌｉｎｉｃａｌ Ｉｍｍｕｎｏｌｏｇｙ Ｖｏｌ．１１３，Ｎｏ．６, 2004, ｐ．１１０９-１１１６
Attorney, Agent or Firm:
Ryoichi Takaoka
Nao Oda
Nao Oda