Title:
薬物送達などの用途のための発泡体および粒子
Document Type and Number:
Japanese Patent JP2013526584
Kind Code:
A
Abstract:
The present invention generally relates to foams and, in particular, to foams for applications such as drug delivery, and particles that are made from such foams. One aspect relates to foams or particles containing pharmaceutically active agents. The foam may comprise a pharmaceutically acceptable polymeric carrier. In some cases, the foam or particle has an unexpectedly high specific surface area. A high specific surface area may, in some cases, facilitate delivery or release of the pharmaceutically active agent when the foam or particles made from the foam (e.g., by milling) are administered to a subject. The foam may also exhibit a relatively high loading of the pharmaceutically active agent. In some cases, the foam may be a microcellular foam. In one set of embodiments, the foam is created using a supercritical fluid, such as supercritical C02. For example, a precursor to the foam, containing a pharmaceutically active agent, may be mixed with a foaming agent, then the pressure decreased to cause the foaming agent to expand, thereby causing a foam to form. The foam may then be subsequently ground or milled, or otherwise processed to form particles.
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Inventors:
Ladabag, Costa
Galley, Rodrigo E.
Kazu, David
Manoharan, Binosan
Rieger, Jens B.
Cortenburg, Laurent Sebastian
Waits, David A.
Galley, Rodrigo E.
Kazu, David
Manoharan, Binosan
Rieger, Jens B.
Cortenburg, Laurent Sebastian
Waits, David A.
Application Number:
JP2013511392A
Publication Date:
June 24, 2013
Filing Date:
May 20, 2011
Export Citation:
Assignee:
President and Fellows of Harvard College
International Classes:
A61K9/58; A61K31/4174; A61K31/56; A61K45/00; A61K47/32; A61K47/34
Attorney, Agent or Firm:
Hidesaku Yamamoto
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa