Title:
コロイド微粒子物を含有するミクロセル様の発泡体を包含する発泡体
Document Type and Number:
Japanese Patent JP2013526585
Kind Code:
A
Abstract:
The present invention generally relates to foams and particles made from such foams, for applications such as drug delivery. The foams or particles may comprise a pharmaceutically acceptable polymeric carrier. In some cases, the foams may include colloidal particulates. A first aspect of the present invention is generally related to polymer-based foams or particles containing pharmaceutically active agents. In some cases, the foam or particle may contain smaller colloidal particulates therein. Such colloidal particulates may be used, for example, to limit the amount of material within certain regions of the foam, or exclude pharmaceutically active agents from being located within certain portions of the foam, which may useful for enhancing release of pharmaceutically active agents from the foam. In some cases, the colloidal particulates may cause the foam or particle to have an unexpectedly high specific surface area. The foam, in certain embodiments, can exhibit a relatively high loading of the pharmaceutically active agent. The foam may be microcellular in certain instances. The foam may also be created using a supercritical fluid, for example, supercritical C02. For instance, a precursor to the foam, containing a pharmaceutically active agent, a pharmaceutically acceptable polymeric carrier, and colloidal particulates, can be mixed with a foaming agent. The pressure may then be decreased, thereby causing the foaming agent to expand and causing a foam to form. The foam may also be ground or milled, or otherwise processed, to form particles such as nanoparticles.
Inventors:
Ladabag, Costa
Galley, Rodrigo E.
Kazu, David
Manoharan, Binosan
Rieger, Jens B.
Cortenburg, Laurent Sebastian
Waits, David A.
Galley, Rodrigo E.
Kazu, David
Manoharan, Binosan
Rieger, Jens B.
Cortenburg, Laurent Sebastian
Waits, David A.
Application Number:
JP2013511393A
Publication Date:
June 24, 2013
Filing Date:
May 20, 2011
Export Citation:
Assignee:
President and Fellows of Harvard College
International Classes:
A61K9/12; A61K9/10; A61K47/04; A61K47/32
Attorney, Agent or Firm:
Hidesaku Yamamoto
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa